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Squamous cell skin papilloma

MedGen UID:: 83397
•Concept ID:: C0345983
•: Neoplastic Process

Synonyms:	Dyskeratotic papilloma of skin; Dyskeratotic papilloma of the skin; Dyskeratotic skin papilloma; Hyperkeratotic papilloma of skin; hyperkeratotic papilloma of skin; hyperkeratotic papilloma of the skin; hyperkeratotic skin papilloma; Parakeratotic papilloma of skin; parakeratotic papilloma of skin; parakeratotic papilloma of the skin; parakeratotic skin papilloma; Squamous cell papilloma of skin; squamous cell papilloma of skin; squamous cell papilloma of the skin; squamous cell skin papilloma; zone of skin squamous papilloma
SNOMED CT:	Squamous cell papilloma of skin (254661000); Parakeratotic papilloma of skin (254661000); Hyperkeratotic papilloma of skin (254661000); Dyskeratotic papilloma of skin (254661000)

Monarch Initiative:	MONDO:0004204

Definition

A squamous papilloma that involves the zone of skin. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSquamous cell skin papilloma

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign epithelial neoplasm
      - Benign epithelial skin neoplasm
        Skin papilloma
        Squamous cell skin papilloma

Professional guidelines

PubMed

Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma-An Update from the Pathologist's Point of View.

Cocuz IG, Popelea MC, Niculescu R, Manea A, Sabău AH, Tinca AC, Szoke AR, Budin CE, Stoian A, Morariu SH, Cotoi TC, Cocuz ME, Cotoi OS
Int J Mol Sci 2024 Feb 13;25(4) doi: 10.3390/ijms25042220. PMID: 38396897 Free PMC Article

STING expression and response to treatment with STING ligands in premalignant and malignant disease.

Baird JR, Feng Z, Xiao HD, Friedman D, Cottam B, Fox BA, Kramer G, Leidner RS, Bell RB, Young KH, Crittenden MR, Gough MJ
PLoS One 2017;12(11):e0187532. Epub 2017 Nov 14 doi: 10.1371/journal.pone.0187532. PMID: 29135982 Free PMC Article

Longitudinal Erythronychia: Retrospective Single-Center Study Evaluating Differential Diagnosis and the Likelihood of Malignancy.

Jellinek NJ, Lipner SR
Dermatol Surg 2016 Mar;42(3):310-9. doi: 10.1097/DSS.0000000000000594. PMID: 26918968

See all (10)

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864

Molecular Biology of Basal and Squamous Cell Carcinomas.

Boeckmann L, Martens MC, Emmert S
Adv Exp Med Biol 2020;1268:171-191. doi: 10.1007/978-3-030-46227-7_9. PMID: 32918219

The low-risk papillomaviruses.

Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475

Skin precancer.

Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

HPV-related follicular cysts.

Aloi F, Tomasini C, Pippione M
Am J Dermatopathol 1992 Feb;14(1):37-41. doi: 10.1097/00000372-199202000-00006. PMID: 1324621

See all (172)

Diagnosis

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.

Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388 Free PMC Article

Pigmented condyloma acuminatum.

Shimizu A, Kato M, Ishikawa O
J Dermatol 2014 Apr;41(4):337-9. Epub 2014 Feb 24 doi: 10.1111/1346-8138.12428. PMID: 24611994

HPV-related follicular cysts.

Aloi F, Tomasini C, Pippione M
Am J Dermatopathol 1992 Feb;14(1):37-41. doi: 10.1097/00000372-199202000-00006. PMID: 1324621

Primary disorders of hyperpigmentation.

Fulk CS
J Am Acad Dermatol 1984 Jan;10(1):1-16. doi: 10.1016/s0190-9622(84)80032-8. PMID: 6420449

Epibulbar tumors in childhood.

Elsas FJ, Green WR
Am J Ophthalmol 1975 Jun;79(6):1001-7. doi: 10.1016/0002-9394(75)90685-6. PMID: 166560

See all (165)

Therapy

Organ transplantation and skin--principles and concepts.

Hofbauer GF, Freiberger SN, Iotzova-Weiss G, Shafaeddin B, Dziunycz PJ
Curr Probl Dermatol 2012;43:1-8. Epub 2012 Feb 17 doi: 10.1159/000335137. PMID: 22377915

Antioxidants in chemoprevention of skin cancer.

Ahmad N, Katiyar SK, Mukhtar H
Curr Probl Dermatol 2001;29:128-39. doi: 10.1159/000060662. PMID: 11225193

Large-cell acanthoma.

Weinstock MA
Am J Dermatopathol 1992 Apr;14(2):133-4; discussion 135. doi: 10.1097/00000372-199204000-00007. PMID: 1566973

Large-cell acanthoma. A distinctive keratosis.

Rabinowitz AD, Inghirami G
Am J Dermatopathol 1992 Apr;14(2):136-8; discussion 139. PMID: 1348913

Cutting oils and squamous-cell carcinoma. I. Incidence in a plant with a report of six cases.

MASTROMATTEO E
Br J Ind Med 1955 Jul;12(3):240-3. doi: 10.1136/oem.12.3.240. PMID: 13240029 Free PMC Article

See all (117)

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.

Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388 Free PMC Article

Lichen sclerosus and squamous cell carcinoma.

Gutiérrez-Pascual M, Vicente-Martín FJ, López-Estebaranz JL
Actas Dermosifiliogr 2012 Jan;103(1):21-8. Epub 2012 Mar 24 doi: 10.1016/j.adengl.2011.05.004. PMID: 22445563

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, van Oostrom CT, van den Berg J, van den Aardweg GJ, Lozano G, van Steeg H, Jacks T, de Vries A
Mol Cell Biol 2004 Oct;24(20):8884-94. doi: 10.1128/MCB.24.20.8884-8894.2004. PMID: 15456863 Free PMC Article

Cutting oils and squamous-cell carcinoma. I. Incidence in a plant with a report of six cases.

MASTROMATTEO E
Br J Ind Med 1955 Jul;12(3):240-3. doi: 10.1136/oem.12.3.240. PMID: 13240029 Free PMC Article

See all (67)

Clinical prediction guides

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.

Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388 Free PMC Article

Pigmented condyloma acuminatum.

Shimizu A, Kato M, Ishikawa O
J Dermatol 2014 Apr;41(4):337-9. Epub 2014 Feb 24 doi: 10.1111/1346-8138.12428. PMID: 24611994

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.

Pelengaris S, Littlewood T, Khan M, Elia G, Evan G
Mol Cell 1999 May;3(5):565-77. doi: 10.1016/s1097-2765(00)80350-0. PMID: 10360173

Skin precancer.

Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Primary disorders of hyperpigmentation.

Fulk CS
J Am Acad Dermatol 1984 Jan;10(1):1-16. doi: 10.1016/s0190-9622(84)80032-8. PMID: 6420449

See all (127)

Recent systematic reviews

Benefits and challenges of Mohs micrographic surgery for human papilloma virus-associated cutaneous malignancies: a systematic review.

Riva HR, Yoon T, Mohammad K Shalabi M, Hussain A, Khachemoune A
Arch Dermatol Res 2024 Sep 14;316(9):617. doi: 10.1007/s00403-024-03364-8. PMID: 39276166

The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.

Chen P, Chen F, Zhou B
Cutan Ocul Toxicol 2019 Jun;38(2):105-111. Epub 2019 Jan 28 doi: 10.1080/15569527.2018.1553180. PMID: 30501438

See all (2)

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Squamous cell skin papilloma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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