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Ovarian seromucinous tumor

MedGen UID:: 83409
•Concept ID:: C0346166
•: Neoplastic Process

Synonyms:	mixed epithelial neoplasm of ovary; mixed epithelial neoplasm of the ovary; Mixed epithelial tumor of ovary; mixed epithelial tumor of ovary; mixed epithelial tumor of the ovary; mixed epithelial tumour of ovary; mixed epithelial tumour of the ovary; ovarian mixed epithelial neoplasm; ovarian mixed epithelial tumor; ovarian mixed epithelial tumour; Ovarian Seromucinous Tumor; ovarian seromucinous tumor; ovarian Seromucinous tumor; ovarian Seromucinous tumour
SNOMED CT:	Mixed epithelial tumor of ovary (254855000)

Monarch Initiative:	MONDO:0003811

Definition

A benign, borderline, or malignant mixed epithelial tumor of the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOvarian seromucinous tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Ovarian epithelial tumor
        Ovarian seromucinous tumor
        Benign Ovarian Seromucinous Tumor
        Ovarian Seromucinous Adenofibroma
        Ovarian Seromucinous Cystadenoma
        Borderline Ovarian Seromucinous Tumor
        Borderline Ovarian Seromucinous Tumor/Atypical Proliferative Ovarian Seromucinous Tumor
        Borderline Ovarian Seromucinous Tumor/Atypical Proliferative Ovarian Seromucinous Tumor with Microinvasion
        Ovarian seromucinous carcinoma
        Recurrent Ovarian Seromucinous Carcinoma
        Refractory Ovarian Seromucinous Carcinoma

Professional guidelines

PubMed

Management of Borderline ovarian tumors (BOT): results of a retrospective, single center study in Switzerland.

Kipp B, Vidal A, Lenick D, Christmann-Schmid C
J Ovarian Res 2023 Jan 23;16(1):20. doi: 10.1186/s13048-023-01107-3. PMID: 36691070 Free PMC Article

Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.

Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971 Free PMC Article

Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.

Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

See all (4)

Recent clinical studies

Etiology

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.

Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650

Mucinous Ovarian Tumors.

Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115

Cancer Implications for Patients with Endometriosis.

Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216

The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.

Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190 Free PMC Article

Seromucinous Tumors of the Ovary. What's in a Name?

Kurman RJ, Shih IeM
Int J Gynecol Pathol 2016 Jan;35(1):78-81. doi: 10.1097/PGP.0000000000000266. PMID: 26598986 Free PMC Article

See all (43)

Diagnosis

Extraovarian seromucinous borderline tumor: Case report and literature review.

Sakata M, Mabuchi S, Maeda M, Nagata S, Tanaka J, Kamiura S
J Obstet Gynaecol Res 2024 Jul;50(7):1263-1267. Epub 2024 Apr 28 doi: 10.1111/jog.15955. PMID: 38679428

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.

Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650

Ovarian mucinous and seromucinous neoplasms: problematic aspects and modern diagnostic approach.

Talia KL, Parra-Herran C, McCluggage WG
Histopathology 2022 Jan;80(2):255-278. Epub 2021 Oct 20 doi: 10.1111/his.14399. PMID: 33963606

Mucinous Ovarian Tumors.

Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115

Endometriosis-associated ovarian neoplasia.

Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

See all (61)

Therapy

New sonographic marker of borderline ovarian tumor: microcystic pattern of papillae and solid components.

Timor-Tritsch IE, Foley CE, Brandon C, Yoon E, Ciaffarrano J, Monteagudo A, Mittal K, Boyd L
Ultrasound Obstet Gynecol 2019 Sep;54(3):395-402. Epub 2019 Aug 8 doi: 10.1002/uog.20283. PMID: 30950132

Morphologic Reproducibility, Genotyping, and Immunohistochemical Profiling Do Not Support a Category of Seromucinous Carcinoma of the Ovary.

Rambau PF, McIntyre JB, Taylor J, Lee S, Ogilvie T, Sienko A, Morris D, Duggan MA, McCluggage WG, Köbel M
Am J Surg Pathol 2017 May;41(5):685-695. doi: 10.1097/PAS.0000000000000812. PMID: 28125452

Characteristics of ovarian and uterine cancers in a cohort of in vitro fertilization patients.

Venn A, Jones P, Quinn M, Healy D
Gynecol Oncol 2001 Jul;82(1):64-8. doi: 10.1006/gyno.2001.6209. PMID: 11426963

Oral contraceptive use and benign gynecologic conditions. A review.

Chiaffarino F, Parazzini F, La Vecchia C, Ricci E, Crosignani PG
Contraception 1998 Jan;57(1):11-8. doi: 10.1016/s0010-7824(97)00201-1. PMID: 9554245

Risk factors for seromucinous benign ovarian cysts in northern Italy.

Parazzini F, Moroni S, Negri E, La Vecchia C, Mezzopane R, Crosignani PG
J Epidemiol Community Health 1997 Aug;51(4):449-52. doi: 10.1136/jech.51.4.449. PMID: 9328556 Free PMC Article

See all (7)

Prognosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.

Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792

Ovarian seromucinous carcinoma: an independent epithelial ovarian cancer?

Hu Y, Fu K, Liu H, He Q, Qiu X, Yang W, Zhang Y
J Ovarian Res 2023 Jan 20;16(1):18. doi: 10.1186/s13048-023-01100-w. PMID: 36670456 Free PMC Article

Clinicopathological Characteristics and Prognosis of 91 Patients with Seromucinous and Mucinous Borderline Ovarian Tumors: a Comparative Study.

Wu B, Li J, Tao X, Wang J, Zhu G, Lu X, Chen R
Reprod Sci 2023 Jun;30(6):1927-1937. Epub 2022 Dec 13 doi: 10.1007/s43032-022-01114-7. PMID: 36512190

Endometriosis-associated ovarian neoplasia.

Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors.

Karpathiou G, Chauleur C, Corsini T, Venet M, Habougit C, Honeyman F, Forest F, Peoc'h M
Ann Diagn Pathol 2017 Apr;27:28-33. Epub 2017 Jan 7 doi: 10.1016/j.anndiagpath.2017.01.002. PMID: 28325358

See all (29)

Clinical prediction guides

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.

Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804

Endometriosis-associated ovarian neoplasia.

Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Differentiation of Seromucinous Borderline Tumor from Serous Borderline Tumor on MR Imaging.

Kurata Y, Kido A, Moribata Y, Kameyama K, Minamiguchi S, Konishi I, Togashi K
Magn Reson Med Sci 2018 Jul 10;17(3):211-217. Epub 2017 Oct 6 doi: 10.2463/mrms.mp.2017-0055. PMID: 28993546 Free PMC Article

Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors.

Karpathiou G, Chauleur C, Corsini T, Venet M, Habougit C, Honeyman F, Forest F, Peoc'h M
Ann Diagn Pathol 2017 Apr;27:28-33. Epub 2017 Jan 7 doi: 10.1016/j.anndiagpath.2017.01.002. PMID: 28325358

See all (23)

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Ovarian seromucinous tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Clinical resources

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