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Orbit Capillary Hemangioma

MedGen UID:
83421
•Concept ID:
C0346351
•
Neoplastic Process
Synonyms: Capillary Angioma of Orbit; Capillary Angioma of the Orbit; Capillary hemangioma of orbit; Capillary Hemangioma of Orbit; Capillary Hemangioma of the Orbit; Orbit Capillary Angioma
SNOMED CT: Capillary hemangioma of orbit (254997007)

Definition

A capillary hemangioma arising from the orbit. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbit Capillary Hemangioma

Professional guidelines

PubMed

Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Management.
Alvarez R, Mastorakos P, Hogan E, Scott G, Lonser RR, Wiley HE, Chew EY, Chittiboina P
Neurosurgery 2021 Apr 15;88(5):1012-1020. doi: 10.1093/neuros/nyaa565. PMID: 33442737Free PMC Article
β-blockers in the treatment of periocular infantile hemangioma.
Al-Haddad C, El Salloukh NA, El Moussawi Z
Curr Opin Ophthalmol 2019 Sep;30(5):319-325. doi: 10.1097/ICU.0000000000000591. PMID: 31394556
New developments in the management of periocular capillary hemangioma in children.
Ni N, Wagner RS, Langer P, Guo S
J Pediatr Ophthalmol Strabismus 2011 Sep-Oct;48(5):269-76; quiz 268, 277. Epub 2010 Oct 21 doi: 10.3928/01913913-20101018-02. PMID: 20964274

Recent clinical studies

Etiology

Unique properties of clinical manifestation and magnetic resonance imaging for differential diagnosis of optic nerve hemangioblastoma.
Liu H, Yang B, Chen Y, Guo S, Jiang L
Eye (Lond) 2024 Dec;38(18):3562-3568. Epub 2024 Oct 2 doi: 10.1038/s41433-024-03363-z. PMID: 39358441Free PMC Article
Ocular and Periocular Tumors in Asian Indian Children and Adolescents.
Kaliki S, Das AV
Indian Pediatr 2020 Jun 15;57(6):512-514. Epub 2020 Mar 12 PMID: 32221055
Leksell Radiosurgery for the 3 H Tumors: Hemangiomas, Hemangioblastomas, and Hemangiopericytomas.
Johnson S, Niranjan A, Kano H, Lunsford LD
Prog Neurol Surg 2019;34:223-231. Epub 2019 May 16 doi: 10.1159/000493068. PMID: 31096251
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Periorbital lesions misdiagnosed as dermoid cysts.
Al-Muhaylib A, Alkatan HM, Al-Faky YH, Alsuhaibani AH
J AAPOS 2017 Dec;21(6):509-511. Epub 2017 Oct 28 doi: 10.1016/j.jaapos.2017.07.215. PMID: 29107796

Diagnosis

Intracranial extension of an intramuscular haemangioma of superior rectus: case report and literature review.
Al-Johani S, Al-Romaih A
BMC Ophthalmol 2022 May 23;22(1):232. doi: 10.1186/s12886-022-02429-4. PMID: 35606735Free PMC Article
Metastatic neuroblastoma mimicking an infantile hemangioma.
Chiloeches Fernández C, Feito Rodríguez M, Rodríguez Bandera A, Quintana Castanedo L, Ruiz Bravo E, de Lucas Laguna R
Pediatr Dermatol 2021 Jan;38(1):316-317. Epub 2020 Oct 25 doi: 10.1111/pde.14421. PMID: 33099811
Ocular and Periocular Tumors in Asian Indian Children and Adolescents.
Kaliki S, Das AV
Indian Pediatr 2020 Jun 15;57(6):512-514. Epub 2020 Mar 12 PMID: 32221055
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Periorbital and orbital infantile hemangiomas.
Stass-Isern M
Int Ophthalmol Clin 2014 Summer;54(3):73-82. doi: 10.1097/IIO.0000000000000039. PMID: 24879105

Therapy

The Experience Of Intralesional Bleomycin For Orbital Vascular Anomalies.
Kamil Z, Qurban Q, Hassan Khan MT
J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):240-243. PMID: 34137537
β-blockers in the treatment of periocular infantile hemangioma.
Al-Haddad C, El Salloukh NA, El Moussawi Z
Curr Opin Ophthalmol 2019 Sep;30(5):319-325. doi: 10.1097/ICU.0000000000000591. PMID: 31394556
Periorbital and orbital infantile hemangiomas.
Stass-Isern M
Int Ophthalmol Clin 2014 Summer;54(3):73-82. doi: 10.1097/IIO.0000000000000039. PMID: 24879105
Propranolol therapy for infantile hemangioma.
Gunturi N, Ramgopal S, Balagopal S, Scott JX
Indian Pediatr 2013 Mar;50(3):307-13. doi: 10.1007/s13312-013-0098-9. PMID: 23680605
The use of propranolol in the treatment of periocular infantile haemangiomas: a review.
Claerhout I, Buijsrogge M, Delbeke P, Walraedt S, De Schepper S, De Moerloose B, De Groote K, Decock C
Br J Ophthalmol 2011 Sep;95(9):1199-202. Epub 2010 Dec 3 doi: 10.1136/bjo.2010.192245. PMID: 21131380

Prognosis

Optic Nerve Hemangioblastoma: Review.
Darbari S, Meena RK, Sawarkar D, Doddamani RS
World Neurosurg 2019 Aug;128:211-215. Epub 2019 May 1 doi: 10.1016/j.wneu.2019.04.224. PMID: 31054346
Benign hamartoma masquerading as a deep orbital hemangioma.
Earl JB, Kramm L, Durairaj VD
J Pediatr Ophthalmol Strabismus 2009 Jul-Aug;46(4):228-31. Epub 2009 Mar 20 doi: 10.3928/01913913-20090706-10. PMID: 19645403
Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications.
Kreusel KM
Fam Cancer 2005;4(1):43-7. doi: 10.1007/s10689-004-1327-0. PMID: 15883709
Acute adduction deficit in a 7-week-old infant.
Jain S, Goulstine D, Gottlob I
Strabismus 2002 Dec;10(4):241-4. doi: 10.1076/stra.10.4.241.13835. PMID: 12660849
Capillary hemangioma of the lids and orbit: an analysis of the clinical features and therapeutic results in 101 cases.
Haik BG, Jakobiec FA, Ellsworth RM, Jones IS
Ophthalmology 1979 May;86(5):760-92. doi: 10.1016/s0161-6420(79)35452-5. PMID: 545208

Clinical prediction guides

The Experience Of Intralesional Bleomycin For Orbital Vascular Anomalies.
Kamil Z, Qurban Q, Hassan Khan MT
J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):240-243. PMID: 34137537
Clinical and Radiological Evaluation of Periocular Infantile Hemangioma Treated With Oral Propranolol: A Case Series.
Ginguerra MA, Saito O, Fernandes JBVD, Castro DS, Matayoshi S
Am J Ophthalmol 2018 Jan;185:48-55. Epub 2017 Nov 15 doi: 10.1016/j.ajo.2017.10.021. PMID: 29103963
Beta blocker treatment of infantile conjunctival hemangiomas--observations from 2 cases.
Chang TC, Estes R
J AAPOS 2014 Feb;18(1):80-2. doi: 10.1016/j.jaapos.2013.09.013. PMID: 24568991
Capillary haemangioma successfully treated with oral beta-blocker in Dar es Salaam, Tanzania: a case report.
Cloke A, Lim LT, Blaikie A
Semin Ophthalmol 2013 Jan;28(1):32-3. doi: 10.3109/08820538.2012.730100. PMID: 23305438
Propranolol for the treatment of orbital infantile hemangiomas.
Fridman G, Grieser E, Hill R, Khuddus N, Bersani T, Slonim C
Ophthalmic Plast Reconstr Surg 2011 May-Jun;27(3):190-4. doi: 10.1097/IOP.0b013e318201d344. PMID: 21283032

Recent systematic reviews

Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids.
Xu S, Jia R, Ge S, Lin M, Fan X
J Paediatr Child Health 2014 Apr;50(4):271-9. Epub 2013 Dec 23 doi: 10.1111/jpc.12464. PMID: 24754793
The use of propranolol in the management of periocular capillary haemangioma--a systematic review.
Spiteri Cornish K, Reddy AR
Eye (Lond) 2011 Oct;25(10):1277-83. Epub 2011 Jul 8 doi: 10.1038/eye.2011.164. PMID: 21738233Free PMC Article

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