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Metastatic Malignant Neoplasm in the Vagina

MedGen UID:
83435
•Concept ID:
C0346997
•
Neoplastic Process
Synonyms: Cancer metastatic to vagina; Metastasis to the Vagina; Metastasis to vagina; Metastasis to Vagina; Metastatic malignant neoplasm of vagina; Metastatic Malignant Neoplasm to the Vagina; Metastatic malignant neoplasm to vagina; Metastatic Neoplasm to the Vagina; Secondary malignant neoplasm of vagina; Secondary Tumor to the Vagina; Secondary tumor to vagina; Secondary Tumor to Vagina
SNOMED CT: Secondary tumor to vagina (94668004); Metastasis to vagina (94668004); Secondary malignant neoplasm of vagina (94668004); Metastatic malignant neoplasm to vagina (94668004); Cancer metastatic to vagina (94668004); Metastatic malignant neoplasm of vagina (94668004)

Definition

A malignant neoplasm that has spread to the vagina from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Vagina

Professional guidelines

PubMed

Gynecological sarcomas, surgical management: primary, metastatic, and recurrent disease.
Ferron G, Bataillon G, Martinez A, Chibon F, Valentin T
Int J Gynecol Cancer 2024 Mar 4;34(3):393-402. doi: 10.1136/ijgc-2023-004582. PMID: 38438176
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health.
Faubion SS, Larkin LC, Stuenkel CA, Bachmann GA, Chism LA, Kagan R, Kaunitz AM, Krychman ML, Parish SJ, Partridge AH, Pinkerton JV, Rowen TS, Shapiro M, Simon JA, Goldfarb SB, Kingsberg SA
Menopause 2018 Jun;25(6):596-608. doi: 10.1097/GME.0000000000001121. PMID: 29762200

Recent clinical studies

Etiology

Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health.
Faubion SS, Larkin LC, Stuenkel CA, Bachmann GA, Chism LA, Kagan R, Kaunitz AM, Krychman ML, Parish SJ, Partridge AH, Pinkerton JV, Rowen TS, Shapiro M, Simon JA, Goldfarb SB, Kingsberg SA
Menopause 2018 Jun;25(6):596-608. doi: 10.1097/GME.0000000000001121. PMID: 29762200
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Natural history and epidemiology of HPV infection and cervical cancer.
Castellsagué X
Gynecol Oncol 2008 Sep;110(3 Suppl 2):S4-7. doi: 10.1016/j.ygyno.2008.07.045. PMID: 18760711

Diagnosis

The Endometrial Microbiota: Challenges and Prospects.
Kaluanga Bwanga P, Tremblay-Lemoine PL, Timmermans M, Ravet S, Munaut C, Nisolle M, Henry L
Medicina (Kaunas) 2023 Aug 25;59(9) doi: 10.3390/medicina59091540. PMID: 37763663Free PMC Article
Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Prepubertal vulvovaginopathies.
Pokorny SF
Obstet Gynecol Clin North Am 1992 Mar;19(1):39-58. PMID: 1584544

Therapy

Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077
Adolescent menstrual irregularity.
Mansfield MJ, Emans SJ
J Reprod Med 1984 Jun;29(6):399-410. PMID: 6379175
Cancer of the vagina.
Cavanagh D, Praphat H, Ruffolo EH
Obstet Gynecol Annu 1980;9:311-25. PMID: 7402504

Prognosis

Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077
Cancer of the vagina.
Cavanagh D, Praphat H, Ruffolo EH
Obstet Gynecol Annu 1980;9:311-25. PMID: 7402504

Clinical prediction guides

Uterine fibroids and longitudinal profiles of the vaginal microbiota in a cohort presenting for transvaginal ultrasound.
Robbins SJ, Brown SE, Stennett CA, Tuddenham S, Johnston ED, Wnorowski AM, Ravel J, He X, Mark KS, Brotman RM
PLoS One 2024;19(2):e0296346. Epub 2024 Feb 5 doi: 10.1371/journal.pone.0296346. PMID: 38315688Free PMC Article
Lateral Pelvic Sidewall Nodes.
Kelly ME, Heriot AG
Dis Colon Rectum 2023 Mar 1;66(3):355-357. Epub 2023 Jan 4 doi: 10.1097/DCR.0000000000002706. PMID: 36728599
Clinical and morphopathological assay in vulvovaginal candidiasis.
Manolea MM, Istrate-Ofiţeru AM, Săndulescu MS, Camen IV, Piciu IA, Dijmărescu AL, Vrabie SC, Neamţu SD, Obleagă CV, Siminel MA
Rom J Morphol Embryol 2022 Jul-Sep;63(3):511-520. doi: 10.47162/RJME.63.3.05. PMID: 36588489Free PMC Article
Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428
Gestational trophoblastic tumors.
Lurain JR
Semin Surg Oncol 1990;6(6):347-53. doi: 10.1002/ssu.2980060610. PMID: 2175931

Recent systematic reviews

External beam radiotherapy versus vaginal brachytherapy in patients with stage II endometrial cancer: a systematic review and meta-analysis.
Narasimhulu DM, Cope A, Riaz IB, Petersen I, Cilby W, Langstraat C, Glaser G, Kumar A, Cappuccio S, Murad MH, West C, Mariani A
Int J Gynecol Cancer 2020 Jun;30(6):797-805. Epub 2020 Mar 26 doi: 10.1136/ijgc-2020-001199. PMID: 32221021
Diagnostic Performance of Transvaginal Ultrasound for Detecting Cervical Invasion In Women With Endometrial Carcinoma: A Systematic Review and Meta-analysis.
Alcázar JL, Pérez L, Güell O, Haro N, Manzour N, Chacon E, Jurado M
J Ultrasound Med 2019 Jan;38(1):179-189. Epub 2018 May 6 doi: 10.1002/jum.14682. PMID: 29732585
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023
Pregnancy and genital sarcoma: a systematic review of the literature.
Matsuo K, Eno ML, Im DD, Rosenshein NB
Am J Perinatol 2009 Aug;26(7):507-18. Epub 2009 Mar 13 doi: 10.1055/s-0029-1215428. PMID: 19288396

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