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Metastatic Malignant Neoplasm in the Vulva

MedGen UID:
83436
•Concept ID:
C0346998
•
Neoplastic Process
Synonyms: Cancer metastatic to vulva; Metastasis to the Vulva; Metastatic malignant neoplasm of vulva; Metastatic Malignant Neoplasm to the Vulva; Metastatic malignant neoplasm to vulva; Metastatic Neoplasm to the Vulva; Secondary cancer of the vulva; Secondary malignant neoplasm of vulva; Vulvar Metastasis
SNOMED CT: Secondary malignant neoplasm of vulva (94681006); Metastatic malignant neoplasm to vulva (94681006); Cancer metastatic to vulva (94681006); Metastatic malignant neoplasm of vulva (94681006); Secondary cancer of the vulva (94681006)

Definition

A malignant neoplasm that has spread to the vulva from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Vulva

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health.
Faubion SS, Larkin LC, Stuenkel CA, Bachmann GA, Chism LA, Kagan R, Kaunitz AM, Krychman ML, Parish SJ, Partridge AH, Pinkerton JV, Rowen TS, Shapiro M, Simon JA, Goldfarb SB, Kingsberg SA
Menopause 2018 Jun;25(6):596-608. doi: 10.1097/GME.0000000000001121. PMID: 29762200
FIGO staging for carcinoma of the vulva, cervix, and corpus uteri.
FIGO Committee on Gynecologic Oncology
Int J Gynaecol Obstet 2014 May;125(2):97-8. Epub 2014 Feb 22 doi: 10.1016/j.ijgo.2014.02.003. PMID: 24630859

Recent clinical studies

Etiology

Evaluation of treatments for Bartholin's cyst or abscess: a systematic review.
Illingworth B, Stocking K, Showell M, Kirk E, Duffy J
BJOG 2020 May;127(6):671-678. Epub 2020 Feb 4 doi: 10.1111/1471-0528.16079. PMID: 31876985
Management of genitourinary syndrome of menopause in women with or at high risk for breast cancer: consensus recommendations from The North American Menopause Society and The International Society for the Study of Women's Sexual Health.
Faubion SS, Larkin LC, Stuenkel CA, Bachmann GA, Chism LA, Kagan R, Kaunitz AM, Krychman ML, Parish SJ, Partridge AH, Pinkerton JV, Rowen TS, Shapiro M, Simon JA, Goldfarb SB, Kingsberg SA
Menopause 2018 Jun;25(6):596-608. doi: 10.1097/GME.0000000000001121. PMID: 29762200
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Natural history and epidemiology of HPV infection and cervical cancer.
Castellsagué X
Gynecol Oncol 2008 Sep;110(3 Suppl 2):S4-7. doi: 10.1016/j.ygyno.2008.07.045. PMID: 18760711
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Diagnosis

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Therapy

Immune checkpoints inhibitors in metastatic squamous cell carcinoma of the vulva.
Assi T, Kattan J, Othman A, Farhat F
Future Oncol 2021 Aug;17(24):3133-3135. Epub 2021 Jul 2 doi: 10.2217/fon-2021-0610. PMID: 34213372
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Evaluation of treatments for Bartholin's cyst or abscess: a systematic review.
Illingworth B, Stocking K, Showell M, Kirk E, Duffy J
BJOG 2020 May;127(6):671-678. Epub 2020 Feb 4 doi: 10.1111/1471-0528.16079. PMID: 31876985
Human papillomavirus and cervical cancer.
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC
Lancet 2013 Sep 7;382(9895):889-99. Epub 2013 Apr 23 doi: 10.1016/S0140-6736(13)60022-7. PMID: 23618600
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Prognosis

Metastatic lipoblastoma-like tumour.
Chia MRH, Windsor M
ANZ J Surg 2023 Mar;93(3):689-691. Epub 2022 Jul 1 doi: 10.1111/ans.17884. PMID: 35775445
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Metastatic adenocarcinoma to the clitoris from the cervix.
Papoutsis D, Haefner HK
Am J Obstet Gynecol 2015 Nov;213(5):738.e1. Epub 2015 May 15 doi: 10.1016/j.ajog.2015.05.029. PMID: 25986031
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Clinical prediction guides

TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Extramammary Paget Disease.
Marcoval J, Penín RM, Vidal A, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2020 May;111(4):306-312. Epub 2020 Apr 9 doi: 10.1016/j.ad.2019.09.003. PMID: 32278442
Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients.
Wohlmuth C, Wohlmuth-Wieser I, May T, Vicus D, Gien LT, Laframboise S
Am J Clin Dermatol 2020 Apr;21(2):285-295. doi: 10.1007/s40257-019-00487-x. PMID: 31784896Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Recent systematic reviews

Evaluation of treatments for Bartholin's cyst or abscess: a systematic review.
Illingworth B, Stocking K, Showell M, Kirk E, Duffy J
BJOG 2020 May;127(6):671-678. Epub 2020 Feb 4 doi: 10.1111/1471-0528.16079. PMID: 31876985
Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review.
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023
Pregnancy and genital sarcoma: a systematic review of the literature.
Matsuo K, Eno ML, Im DD, Rosenshein NB
Am J Perinatol 2009 Aug;26(7):507-18. Epub 2009 Mar 13 doi: 10.1055/s-0029-1215428. PMID: 19288396

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