U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Circulating immune complexes

MedGen UID:
854473
•Concept ID:
C3887628
•
Finding
HPO: HP:0012224

Definition

Persistence of immune complexes in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCirculating immune complexes

Professional guidelines

PubMed

Neuropsychiatric Systemic Lupus Erythematosus: Molecules Involved in Its Imunopathogenesis, Clinical Features, and Treatment.
Justiz-Vaillant AA, Gopaul D, Soodeen S, Arozarena-Fundora R, Barbosa OA, Unakal C, Thompson R, Pandit B, Umakanthan S, Akpaka PE
Molecules 2024 Feb 6;29(4) doi: 10.3390/molecules29040747. PMID: 38398500Free PMC Article
A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890
Ineffectiveness of phenytoin treatment on IgA-containing circulating immune complexes in IgA nephropathy.
Coppo R, Basolo B, Bulzomi MR, Piccoli G
Nephron 1984;36(4):275-6. doi: 10.1159/000183169. PMID: 6709120

Recent clinical studies

Etiology

Unmeasurable capillary C-reactive protein as one of the diagnostic clues of severe hematological pathologies in children in primary settings: Case series.
Piteková B, Zieg J, Konopásek P, Turecký L, Brenner M, Gécz J
Medicine (Baltimore) 2023 Oct 27;102(43):e35776. doi: 10.1097/MD.0000000000035776. PMID: 37904468Free PMC Article
Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis.
Kojima T, Inoue D, Wajima T, Uchida T, Yamada M, Ohsawa I, Oda T
Ren Fail 2022 Dec;44(1):714-723. doi: 10.1080/0886022X.2022.2068445. PMID: 35491890Free PMC Article
Allergy and Ménière's disease.
Derebery MJ, Berliner KI
Curr Allergy Asthma Rep 2007 Nov;7(6):451-6. doi: 10.1007/s11882-007-0069-0. PMID: 17986376
Acute glomerulonephritis.
Yoshizawa N
Intern Med 2000 Sep;39(9):687-94. doi: 10.2169/internalmedicine.39.687. PMID: 10969898
Henoch-Schönlein purpura.
Duquesnoy B
Baillieres Clin Rheumatol 1991 Aug;5(2):253-61. doi: 10.1016/s0950-3579(05)80282-1. PMID: 1756583

Diagnosis

Clostridia and Enteroviruses as Synergistic Triggers of Type 1 Diabetes Mellitus.
Root-Bernstein R, Chiles K, Huber J, Ziehl A, Turke M, Pietrowicz M
Int J Mol Sci 2023 May 6;24(9) doi: 10.3390/ijms24098336. PMID: 37176044Free PMC Article
Henoch-Schönlein purpura.
Duquesnoy B
Baillieres Clin Rheumatol 1991 Aug;5(2):253-61. doi: 10.1016/s0950-3579(05)80282-1. PMID: 1756583
Circulating immune complexes (CIC) in connective tissue diseases (CTD).
Schrieber L, Maini RN
Neth J Med 1984;27(9):327-39. PMID: 6239983
Digoxin-associated thrombocytopaenia.
Pirovino M, Ohnhaus EE, von Felten A
Eur J Clin Pharmacol 1981 Feb;19(3):205-7. doi: 10.1007/BF00561950. PMID: 7215418
IgA-associated glomerulonephritis.
McPhaul JJ Jr
Annu Rev Med 1977;28:37-42. doi: 10.1146/annurev.me.28.020177.000345. PMID: 140622

Therapy

Extra-articular rheumatoid arthritis.
Turesson C
Curr Opin Rheumatol 2013 May;25(3):360-6. doi: 10.1097/BOR.0b013e32835f693f. PMID: 23425964
Henoch-Schönlein purpura.
Duquesnoy B
Baillieres Clin Rheumatol 1991 Aug;5(2):253-61. doi: 10.1016/s0950-3579(05)80282-1. PMID: 1756583
Acne fulminans.
Goldstein B, Chalker DK, Lesher JL Jr
South Med J 1990 Jun;83(6):705-8. doi: 10.1097/00007611-199006000-00030. PMID: 2141435
Therapeutic options in IgA nephropathy.
Clarkson AR, Woodroffe AJ, Aarons IA, Thompson T, Hale GM
Am J Kidney Dis 1988 Nov;12(5):443-8. doi: 10.1016/s0272-6386(88)80043-x. PMID: 3055973
Digoxin-associated thrombocytopaenia.
Pirovino M, Ohnhaus EE, von Felten A
Eur J Clin Pharmacol 1981 Feb;19(3):205-7. doi: 10.1007/BF00561950. PMID: 7215418

Prognosis

A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890
Extra-articular rheumatoid arthritis.
Turesson C
Curr Opin Rheumatol 2013 May;25(3):360-6. doi: 10.1097/BOR.0b013e32835f693f. PMID: 23425964
Vasculitis.
Smith JG Jr
J Dermatol 1995 Nov;22(11):812-22. doi: 10.1111/j.1346-8138.1995.tb03929.x. PMID: 8557852
HIV-related thrombocytopenia.
Blockmans D, Vermylen J
Acta Clin Belg 1992;47(2):117-23. doi: 10.1080/17843286.1992.11718217. PMID: 1321536
Therapeutic options in IgA nephropathy.
Clarkson AR, Woodroffe AJ, Aarons IA, Thompson T, Hale GM
Am J Kidney Dis 1988 Nov;12(5):443-8. doi: 10.1016/s0272-6386(88)80043-x. PMID: 3055973

Clinical prediction guides

Immunogenicity/hypersensitivity of biologics.
Leach MW, Rottman JB, Hock MB, Finco D, Rojko JL, Beyer JC
Toxicol Pathol 2014 Jan;42(1):293-300. Epub 2013 Nov 14 doi: 10.1177/0192623313510987. PMID: 24240973
Vasculitis.
Smith JG Jr
J Dermatol 1995 Nov;22(11):812-22. doi: 10.1111/j.1346-8138.1995.tb03929.x. PMID: 8557852
Studies on circulating immune complexes of the liver disease. 4. Clq binding activity.
Arima T, Narumoto J, Shimomura H, Suwaki K, Kunishi K, Yasuhara T, Nagashima H
Gastroenterol Jpn 1980;15(1):27-32. doi: 10.1007/BF02773701. PMID: 6153628
Circulating immune complexes in schistosomiasis.
Bout D, Santoro F, Carlier Y, Bina JC, Capron A
Immunology 1977 Jul;33(1):17-22. PMID: 873574Free PMC Article
The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura.
Lurhuma AZ, Riccomi H, Masson PL
Clin Exp Immunol 1977 Apr;28(1):49-55. PMID: 558848Free PMC Article

Recent systematic reviews

Safety and effectiveness of vasectomy.
Schwingl PJ, Guess HA
Fertil Steril 2000 May;73(5):923-36. doi: 10.1016/s0015-0282(00)00482-9. PMID: 10785217

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...