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Rheumatoid factor-negative juvenile idiopathic arthritis

MedGen UID:
855549
•Concept ID:
C3890205
•
Disease or Syndrome
Synonyms: Juvenile chronic arthritis, polyarticular seronegative; Juvenile idiopathic arthritis, polyarthritis, rheumatoid factor negative; Juvenile polyarthritis without rheumatoid factor; Juvenile rheumatoid factor-negative polyarthritis; juvenile rheumatoid factor-negative polyarthritis; Juvenile seronegative polyarthritis; polyarthritis without rheumatoid factor; Polyarticular JIA, RF-; Polyarticular Juvenile Idiopathic Arthritis, RF-; Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative; rheumatoid factor-negative JIA; rheumatoid factor-negative juvenile idiopathic arthritis; Rheumatoid factor-negative polyarticular JIA; Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
SNOMED CT: Juvenile seronegative polyarthritis (410797009); Juvenile chronic arthritis, polyarticular seronegative (410797009); Juvenile idiopathic arthritis, polyarthritis, rheumatoid factor negative (410797009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0019432
Orphanet: ORPHA85408

Definition

A rare form of polyarticular juvenile idiopathic arthritis characterized by childhood-onset chronic arthritis of unknown cause involving five or more joints at disease onset and absence of rheumatoid factor IgM. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatoid factor-negative juvenile idiopathic arthritis

Professional guidelines

PubMed

Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis.
Brunner HI, Wong R, Nys M, Kou TD, Dominique A, Martini A, Lovell DJ, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
Paediatr Drugs 2020 Dec;22(6):653-672. Epub 2020 Oct 8 doi: 10.1007/s40272-020-00422-2. PMID: 33029724
Safety of weekly adalimumab in the treatment of juvenile idiopathic arthritis and pediatric chronic uveitis.
Correll CK, Bullock DR, Cafferty RM, Vehe RK
Clin Rheumatol 2018 Feb;37(2):549-553. Epub 2017 Nov 4 doi: 10.1007/s10067-017-3890-4. PMID: 29103180
Evaluation of the ILAR criteria for juvenile idiopathic arthritis.
Krumrey-Langkammerer M, Häfner R
J Rheumatol 2001 Nov;28(11):2544-7. PMID: 11708431

Recent clinical studies

Etiology

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Diagnosis

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Therapy

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Prognosis

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Clinical prediction guides

Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication.
Aquilani A, Marafon DP, Marasco E, Nicolai R, Messia V, Perfetti F, Magni-Manzoni S, De Benedetti F
J Rheumatol 2018 Jul;45(7):956-961. Epub 2018 May 1 doi: 10.3899/jrheum.170794. PMID: 29717035

Supplemental Content

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