U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Growing teratoma syndrome

MedGen UID:
856083
•Concept ID:
C3891714
•
Neoplastic Process
Synonyms: Growing Teratoma Syndrome; growing teratoma syndrome; GTS
SNOMED CT: Growing teratoma syndrome (1260180004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017807
Orphanet: ORPHA314613

Definition

A rare neoplastic disorder characterized by benign metastatic masses increasing in size and number after chemotherapy for non-seminomatous germ cell tumors of testis or ovary. It may present at any time after chemotherapy, with a median occurrence within 24 months after treatment completion. Per definition, the resected specimen exclusively contains mature teratoma components, and serum tumor markers have normalized. The retroperitoneum is the most common site, although almost any other localization has been reported. Increased tumor size may cause mechanical compression of vital organs, with renal dysfunction, bowel ischemia and biliary obstruction as major complications. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowing teratoma syndrome

Professional guidelines

PubMed

Mini-review: Evaluation and Management of Retroperitoneal Masses in Patients with Testicular Cancer.
Yang X, Li J, Chin J, Kanesvaran R
Eur Urol Focus 2024 May;10(3):377-379. Epub 2024 Aug 3 doi: 10.1016/j.euf.2024.05.006. PMID: 39098447
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review.
Tanaka K, Toyokawa G, Tagawa T, Ijichi K, Haratake N, Hirai F, Oda Y, Maehara Y
Anticancer Res 2018 May;38(5):3115-3118. doi: 10.21873/anticanres.12571. PMID: 29715149

Recent clinical studies

Etiology

Growing teratoma syndrome in children and adolescents: Prevalence and surgical outcome.
Beati F, Persano G, De Pasquale MD, Martucci C, Madafferi S, Miele E, Stracuzzi A, Di Paolo PL, Natali GL, Alaggio R, Crocoli A, Inserra A
Pediatr Blood Cancer 2024 Aug;71(8):e31126. Epub 2024 Jun 4 doi: 10.1002/pbc.31126. PMID: 38837659
Assessing the risk to develop a growing teratoma syndrome based on molecular and epigenetic subtyping as well as novel secreted biomarkers.
Pongratanakul P, Bremmer F, Pauls S, Poschmann G, Kresbach C, Parmaksiz F, Skowron MA, Fuß J, Stephan A, Paffenholz P, Stühler K, Schüller U, Ströbel P, Heidenreich A, Che Y, Albers P, Nettersheim D
Cancer Lett 2024 Mar 31;585:216673. Epub 2024 Jan 29 doi: 10.1016/j.canlet.2024.216673. PMID: 38296184
Significance of Ultra-Radical Surgery in Extensive Metastatic Ovarian Growing Teratoma Syndrome.
Li S, Wang T, Du H, Tang H, Zhang T, Zhang R, Zhang X, Yang J
Oncology 2023;101(12):773-781. Epub 2023 Aug 9 doi: 10.1159/000533411. PMID: 38096801
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327

Diagnosis

Growing teratoma syndrome: diagnostic challenges and outcomes.
Gracia Segovia M, Cristóbal Quevedo I, Zapardiel Gutiérrez I, Hernández Gutiérrez A
Arch Gynecol Obstet 2024 Sep;310(3):1729-1732. Epub 2024 Aug 7 doi: 10.1007/s00404-024-07679-9. PMID: 39112800
Growing teratoma syndrome in children and adolescents: Prevalence and surgical outcome.
Beati F, Persano G, De Pasquale MD, Martucci C, Madafferi S, Miele E, Stracuzzi A, Di Paolo PL, Natali GL, Alaggio R, Crocoli A, Inserra A
Pediatr Blood Cancer 2024 Aug;71(8):e31126. Epub 2024 Jun 4 doi: 10.1002/pbc.31126. PMID: 38837659
Imaging in pediatric ovarian tumors.
Hanafy AK, Mujtaba B, Yedururi S, Jensen CT, Sanchez R, Austin MT, Morani AC
Abdom Radiol (NY) 2020 Feb;45(2):520-536. doi: 10.1007/s00261-019-02316-5. PMID: 31745573
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Growing teratoma syndrome.
Karam JA, Raj GV
Urology 2009 Oct;74(4):783-4. Epub 2009 Aug 3 doi: 10.1016/j.urology.2009.03.026. PMID: 19647298

Therapy

Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Growing Teratoma Syndrome After Chemotherapy For Ovarian Immature Teratoma.
Imran H, Siddiqui AH, Wilson F, Pashankar F
J Pediatr Hematol Oncol 2020 Oct;42(7):e630-e633. doi: 10.1097/MPH.0000000000001525. PMID: 31205224
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Diagnosis and management of the growing teratoma syndrome: A single-center experience and review of the literature.
Paffenholz P, Pfister D, Matveev V, Heidenreich A
Urol Oncol 2018 Dec;36(12):529.e23-529.e30. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.09.012. PMID: 30446456
Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review.
Tanaka K, Toyokawa G, Tagawa T, Ijichi K, Haratake N, Hirai F, Oda Y, Maehara Y
Anticancer Res 2018 May;38(5):3115-3118. doi: 10.21873/anticanres.12571. PMID: 29715149

Prognosis

Growing teratoma syndrome in children and adolescents: Prevalence and surgical outcome.
Beati F, Persano G, De Pasquale MD, Martucci C, Madafferi S, Miele E, Stracuzzi A, Di Paolo PL, Natali GL, Alaggio R, Crocoli A, Inserra A
Pediatr Blood Cancer 2024 Aug;71(8):e31126. Epub 2024 Jun 4 doi: 10.1002/pbc.31126. PMID: 38837659
Significance of Ultra-Radical Surgery in Extensive Metastatic Ovarian Growing Teratoma Syndrome.
Li S, Wang T, Du H, Tang H, Zhang T, Zhang R, Zhang X, Yang J
Oncology 2023;101(12):773-781. Epub 2023 Aug 9 doi: 10.1159/000533411. PMID: 38096801
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Growing teratoma syndrome.
Karam JA, Raj GV
Urology 2009 Oct;74(4):783-4. Epub 2009 Aug 3 doi: 10.1016/j.urology.2009.03.026. PMID: 19647298

Clinical prediction guides

Significance of Ultra-Radical Surgery in Extensive Metastatic Ovarian Growing Teratoma Syndrome.
Li S, Wang T, Du H, Tang H, Zhang T, Zhang R, Zhang X, Yang J
Oncology 2023;101(12):773-781. Epub 2023 Aug 9 doi: 10.1159/000533411. PMID: 38096801
Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review.
Shahnam A, Sayer R, Herbst U, Sharma R, Yoon WH, Dinihan T, Gao B
Curr Oncol 2022 Jun 7;29(6):4148-4154. doi: 10.3390/curroncol29060331. PMID: 35735440Free PMC Article
Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...