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Necrotizing Enterocolitis Totalis

MedGen UID:
857748
•Concept ID:
C3898154
•
Disease or Syndrome

Definition

A severe and often fatal form of necrotizing enterocolitis, in which diffuse ischemia, necrosis, and pneumatosis intestinalis are evident in the small and large intestine. Short bowel syndrome is common among survivors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrotizing Enterocolitis Totalis

Professional guidelines

PubMed

Commentary on ethical dilemmas in the management of infants with necrotizing enterocolitis totalis.
Richards CA
J Pediatr Surg 2022 Mar;57(3):335-336. Epub 2021 Sep 28 doi: 10.1016/j.jpedsurg.2021.09.036. PMID: 34742577
Commentary on ethical dilemmas in the management of infants with enterocolitis totalis.
Berman L, Levy C, Miller JM
J Pediatr Surg 2022 Mar;57(3):337-338. Epub 2021 Sep 28 doi: 10.1016/j.jpedsurg.2021.09.037. PMID: 34686376
Ethical dilemmas in the management of infants with necrotizing enterocolitis totalis.
Pennington EC, Javid PJ, Sullins V, Mueller C, Hunter CJ
J Pediatr Surg 2022 Mar;57(3):329-334. Epub 2021 Sep 21 doi: 10.1016/j.jpedsurg.2021.08.026. PMID: 34654549

Recent clinical studies

Etiology

Ex Utero Intrapartum Treatment for Prenatally Diagnosed Cervicofacial Lymphatic Malformations.
Gillipelli SR, Peiffer SE, Larabee SM, Ketwaroo P, Rialon KL, Bedwell J, Mehta D, Lee TC, Keswani SG, King A
J Surg Res 2024 Nov;303:628-635. Epub 2024 Oct 21 doi: 10.1016/j.jss.2024.08.026. PMID: 39437601
Endoscopy in Infants With Gastrointestinal Bleeding Has Limited Diagnostic or Therapeutic Benefit.
Bose P, Jacobs AS, Cordova JG, Gray BW, Huff KA, Molleston JP
J Pediatr Gastroenterol Nutr 2022 Oct 1;75(4):514-520. Epub 2022 Jul 18 doi: 10.1097/MPG.0000000000003566. PMID: 35848737
Characteristics and outcomes of a multi-institution cohort of infants with necrotizing enterocolitis totalis.
Rose AT, Zaniletti I, Santore MT, Piazza AJ
J Perinatol 2022 Apr;42(4):440-445. Epub 2021 Aug 28 doi: 10.1038/s41372-021-01191-7. PMID: 34455416Free PMC Article
A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.
Sho S, Neal MD, Sperry J, Hackam DJ
J Pediatr Surg 2014 Jul;49(7):1053-6. Epub 2013 Nov 7 doi: 10.1016/j.jpedsurg.2013.10.023. PMID: 24952787
Risk factors for necrotizing enterocolitis totalis: a case-control study.
Thompson A, Bizzarro M, Yu S, Diefenbach K, Simpson BJ, Moss RL
J Perinatol 2011 Nov;31(11):730-8. Epub 2011 Mar 24 doi: 10.1038/jp.2011.18. PMID: 21436786

Diagnosis

Ex Utero Intrapartum Treatment for Prenatally Diagnosed Cervicofacial Lymphatic Malformations.
Gillipelli SR, Peiffer SE, Larabee SM, Ketwaroo P, Rialon KL, Bedwell J, Mehta D, Lee TC, Keswani SG, King A
J Surg Res 2024 Nov;303:628-635. Epub 2024 Oct 21 doi: 10.1016/j.jss.2024.08.026. PMID: 39437601
Endoscopy in Infants With Gastrointestinal Bleeding Has Limited Diagnostic or Therapeutic Benefit.
Bose P, Jacobs AS, Cordova JG, Gray BW, Huff KA, Molleston JP
J Pediatr Gastroenterol Nutr 2022 Oct 1;75(4):514-520. Epub 2022 Jul 18 doi: 10.1097/MPG.0000000000003566. PMID: 35848737
Necrotizing enterocolitis totalis: High mortality in the absence of an aggressive surgical approach.
Dukleska K, Devin CL, Martin AE, Miller JM, Sullivan KM, Levy C, Prestowitz S, Flathers K, Vinocur CD, Berman L
Surgery 2019 Jun;165(6):1176-1181. Epub 2019 Apr 27 doi: 10.1016/j.surg.2019.03.005. PMID: 31040040
A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.
Sho S, Neal MD, Sperry J, Hackam DJ
J Pediatr Surg 2014 Jul;49(7):1053-6. Epub 2013 Nov 7 doi: 10.1016/j.jpedsurg.2013.10.023. PMID: 24952787
Risk factors for necrotizing enterocolitis totalis: a case-control study.
Thompson A, Bizzarro M, Yu S, Diefenbach K, Simpson BJ, Moss RL
J Perinatol 2011 Nov;31(11):730-8. Epub 2011 Mar 24 doi: 10.1038/jp.2011.18. PMID: 21436786

Therapy

Ex Utero Intrapartum Treatment for Prenatally Diagnosed Cervicofacial Lymphatic Malformations.
Gillipelli SR, Peiffer SE, Larabee SM, Ketwaroo P, Rialon KL, Bedwell J, Mehta D, Lee TC, Keswani SG, King A
J Surg Res 2024 Nov;303:628-635. Epub 2024 Oct 21 doi: 10.1016/j.jss.2024.08.026. PMID: 39437601
Endoscopy in Infants With Gastrointestinal Bleeding Has Limited Diagnostic or Therapeutic Benefit.
Bose P, Jacobs AS, Cordova JG, Gray BW, Huff KA, Molleston JP
J Pediatr Gastroenterol Nutr 2022 Oct 1;75(4):514-520. Epub 2022 Jul 18 doi: 10.1097/MPG.0000000000003566. PMID: 35848737

Prognosis

A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.
Sho S, Neal MD, Sperry J, Hackam DJ
J Pediatr Surg 2014 Jul;49(7):1053-6. Epub 2013 Nov 7 doi: 10.1016/j.jpedsurg.2013.10.023. PMID: 24952787

Clinical prediction guides

A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.
Sho S, Neal MD, Sperry J, Hackam DJ
J Pediatr Surg 2014 Jul;49(7):1053-6. Epub 2013 Nov 7 doi: 10.1016/j.jpedsurg.2013.10.023. PMID: 24952787
Risk factors for necrotizing enterocolitis totalis: a case-control study.
Thompson A, Bizzarro M, Yu S, Diefenbach K, Simpson BJ, Moss RL
J Perinatol 2011 Nov;31(11):730-8. Epub 2011 Mar 24 doi: 10.1038/jp.2011.18. PMID: 21436786

Recent systematic reviews

Necrotizing enterocolitis totalis: High mortality in the absence of an aggressive surgical approach.
Dukleska K, Devin CL, Martin AE, Miller JM, Sullivan KM, Levy C, Prestowitz S, Flathers K, Vinocur CD, Berman L
Surgery 2019 Jun;165(6):1176-1181. Epub 2019 Apr 27 doi: 10.1016/j.surg.2019.03.005. PMID: 31040040

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