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Amniotic fluid embolism

MedGen UID:
8586
•Concept ID:
C0013927
•
Disease or Syndrome
Synonyms: Amniotic Fluid Embolism; Amniotic Fluid Embolisms; Embolism, Amniotic Fluid; Embolisms, Amniotic Fluid
SNOMED CT: Amniotic fluid embolism (17263003); Amniotic fluid embolus (860708004)
 
Monarch Initiative: MONDO:0850046
Orphanet: ORPHA617304

Definition

Acute hypotension or cardiac arrest, acute hypoxia or coagulopathy in the absence of any other potential explanation related to the presence of amniotic fluid or the fetal debris within the maternal vascular system during the antepartum or intrapartum period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmniotic fluid embolism

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine Special Statement: Checklist for initial management of amniotic fluid embolism.
Patient Safety and Quality Committee, Society for Maternal-Fetal Medicine. Electronic address: [email protected], Combs CA, Montgomery DM, Toner LE, Dildy GA
Am J Obstet Gynecol 2021 Apr;224(4):B29-B32. Epub 2021 Jan 6 doi: 10.1016/j.ajog.2021.01.001. PMID: 33417901
Amniotic fluid embolism: principles of early clinical management.
Pacheco LD, Clark SL, Klassen M, Hankins GDV
Am J Obstet Gynecol 2020 Jan;222(1):48-52. Epub 2019 Jul 31 doi: 10.1016/j.ajog.2019.07.036. PMID: 31376394
Amniotic fluid embolism: diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Pacheco LD, Saade G, Hankins GD, Clark SL
Am J Obstet Gynecol 2016 Aug;215(2):B16-24. Epub 2016 Mar 14 doi: 10.1016/j.ajog.2016.03.012. PMID: 26987420

Recent clinical studies

Etiology

Haemostatic support in postpartum haemorrhage: A review of the literature and expert opinion.
Hofer S, Blaha J, Collins PW, Ducloy-Bouthors AS, Guasch E, Labate F, Lança F, Nyfløt LT, Steiner K, Van de Velde M
Eur J Anaesthesiol 2023 Jan 1;40(1):29-38. Epub 2022 Sep 22 doi: 10.1097/EJA.0000000000001744. PMID: 36131564Free PMC Article
Pulmonary Embolism and Amniotic Fluid Embolism.
Coggins AS, Gomez E, Sheffield JS
Obstet Gynecol Clin North Am 2022 Sep;49(3):439-460. doi: 10.1016/j.ogc.2022.02.015. PMID: 36122978
Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Postdelivery Emergencies.
Wheaton N, Al-Abdullah A, Haertlein T
Emerg Med Clin North Am 2019 May;37(2):287-300. doi: 10.1016/j.emc.2019.01.014. PMID: 30940373
Amniotic fluid embolism.
Gist RS, Stafford IP, Leibowitz AB, Beilin Y
Anesth Analg 2009 May;108(5):1599-602. doi: 10.1213/ane.0b013e31819e43a4. PMID: 19372342

Diagnosis

Post-abortion Complications: A Narrative Review for Emergency Clinicians.
Bridwell RE, Long B, Montrief T, Gottlieb M
West J Emerg Med 2022 Oct 23;23(6):919-925. doi: 10.5811/westjem.2022.8.57929. PMID: 36409940Free PMC Article
Pulmonary Embolism and Amniotic Fluid Embolism.
Coggins AS, Gomez E, Sheffield JS
Obstet Gynecol Clin North Am 2022 Sep;49(3):439-460. doi: 10.1016/j.ogc.2022.02.015. PMID: 36122978
Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Amniotic Fluid Embolism.
Shamshirsaz AA, Clark SL
Obstet Gynecol Clin North Am 2016 Dec;43(4):779-790. doi: 10.1016/j.ogc.2016.07.001. PMID: 27816160
Amniotic fluid embolism: diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Pacheco LD, Saade G, Hankins GD, Clark SL
Am J Obstet Gynecol 2016 Aug;215(2):B16-24. Epub 2016 Mar 14 doi: 10.1016/j.ajog.2016.03.012. PMID: 26987420

Therapy

Haemostatic support in postpartum haemorrhage: A review of the literature and expert opinion.
Hofer S, Blaha J, Collins PW, Ducloy-Bouthors AS, Guasch E, Labate F, Lança F, Nyfløt LT, Steiner K, Van de Velde M
Eur J Anaesthesiol 2023 Jan 1;40(1):29-38. Epub 2022 Sep 22 doi: 10.1097/EJA.0000000000001744. PMID: 36131564Free PMC Article
Post-abortion Complications: A Narrative Review for Emergency Clinicians.
Bridwell RE, Long B, Montrief T, Gottlieb M
West J Emerg Med 2022 Oct 23;23(6):919-925. doi: 10.5811/westjem.2022.8.57929. PMID: 36409940Free PMC Article
Anesthesia for Obstetric Disasters.
Fardelmann KL, Alian AA
Anesthesiol Clin 2020 Mar;38(1):85-105. doi: 10.1016/j.anclin.2019.10.005. PMID: 32008659
Amniotic fluid embolism: diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Pacheco LD, Saade G, Hankins GD, Clark SL
Am J Obstet Gynecol 2016 Aug;215(2):B16-24. Epub 2016 Mar 14 doi: 10.1016/j.ajog.2016.03.012. PMID: 26987420
ARDS in pregnancy.
Duarte AG
Clin Obstet Gynecol 2014 Dec;57(4):862-70. doi: 10.1097/GRF.0000000000000067. PMID: 25314088

Prognosis

Association of Pregnancy Characteristics and Maternal Mortality With Amniotic Fluid Embolism.
Mazza GR, Youssefzadeh AC, Klar M, Kunze M, Matsuzaki S, Mandelbaum RS, Ouzounian JG, Matsuo K
JAMA Netw Open 2022 Nov 1;5(11):e2242842. doi: 10.1001/jamanetworkopen.2022.42842. PMID: 36399343Free PMC Article
Pulmonary Embolism and Amniotic Fluid Embolism.
Coggins AS, Gomez E, Sheffield JS
Obstet Gynecol Clin North Am 2022 Sep;49(3):439-460. doi: 10.1016/j.ogc.2022.02.015. PMID: 36122978
Amniotic fluid embolism mortality rate.
Benson MD
J Obstet Gynaecol Res 2017 Nov;43(11):1714-1718. Epub 2017 Aug 17 doi: 10.1111/jog.13445. PMID: 28817205
Amniotic Fluid Embolism.
Sundin CS, Mazac LB
MCN Am J Matern Child Nurs 2017 Jan/Feb;42(1):29-35. doi: 10.1097/NMC.0000000000000292. PMID: 27755062
Amniotic fluid embolism.
Gist RS, Stafford IP, Leibowitz AB, Beilin Y
Anesth Analg 2009 May;108(5):1599-602. doi: 10.1213/ane.0b013e31819e43a4. PMID: 19372342

Clinical prediction guides

Acute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study.
de Lloyd L, Jenkins PV, Bell SF, Mutch NJ, Martins Pereira JF, Badenes PM, James D, Ridgeway A, Cohen L, Roberts T, Field V, Collis RE, Collins PW
J Thromb Haemost 2023 Apr;21(4):862-879. Epub 2022 Dec 22 doi: 10.1016/j.jtha.2022.11.036. PMID: 36696216
Echocardiography findings in amniotic fluid embolism: a systematic review of the literature.
Wiseman D, Simard C, Yang SS, Koolian M, Abenhaim HA, Lipes J
Can J Anaesth 2023 Jan;70(1):151-160. Epub 2022 Oct 28 doi: 10.1007/s12630-022-02343-9. PMID: 36307749
Intraluminal Arterial Filling Defects Misdiagnosed as Pulmonary Emboli: What Else Could They Be?
Rudkovskaia AA, Bandyopadhyay D
Clin Chest Med 2018 Sep;39(3):505-513. doi: 10.1016/j.ccm.2018.04.004. PMID: 30122175
Cell Salvage in Obstetrics.
Goucher H, Wong CA, Patel SK, Toledo P
Anesth Analg 2015 Aug;121(2):465-8. doi: 10.1213/ANE.0000000000000786. PMID: 26197375
Amniotic fluid embolism: pathophysiology and new strategies for management.
Kanayama N, Tamura N
J Obstet Gynaecol Res 2014 Jun;40(6):1507-17. doi: 10.1111/jog.12428. PMID: 24888909

Recent systematic reviews

Echocardiography findings in amniotic fluid embolism: a systematic review of the literature.
Wiseman D, Simard C, Yang SS, Koolian M, Abenhaim HA, Lipes J
Can J Anaesth 2023 Jan;70(1):151-160. Epub 2022 Oct 28 doi: 10.1007/s12630-022-02343-9. PMID: 36307749
Risk factors for fatality in amniotic fluid embolism: a systematic review and analysis of a data pool.
Indraccolo U, Battistoni C, Mastrantonio I, Di Iorio R, Greco P, Indraccolo SR
J Matern Fetal Neonatal Med 2018 Mar;31(5):661-665. Epub 2017 Mar 1 doi: 10.1080/14767058.2017.1293034. PMID: 28282766
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article
Amniotic fluid embolism: what level of scientific evidence can be drawn? A systematic review.
Frati P, Foldes-Papp Z, Zaami S, Busardo FP
Curr Pharm Biotechnol 2014;14(14):1157-62. doi: 10.2174/1389201015666140430101639. PMID: 24804729
Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations.
Knight M, Berg C, Brocklehurst P, Kramer M, Lewis G, Oats J, Roberts CL, Spong C, Sullivan E, van Roosmalen J, Zwart J
BMC Pregnancy Childbirth 2012 Feb 10;12:7. doi: 10.1186/1471-2393-12-7. PMID: 22325370Free PMC Article

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