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Langerhans cell histiocytosis specific to childhood

MedGen UID:
859249
•Concept ID:
C3899655
•
Neoplastic Process
Synonyms: Childhood Langerhans Cell Histiocytosis; childhood Langerhans cell histiocytosis; histiocytosis X specific to childhood; Langerhans cell granulomatosis specific to childhood
 
Monarch Initiative: MONDO:0017025

Definition

Langerhans cell histiocytosis that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLangerhans cell histiocytosis specific to childhood

Professional guidelines

PubMed

A review of pediatric middle ear tumors and analysis of the demographics, management, and survival of pediatric rhabdomyosarcomas of the middle ear.
Janz TA, Camilon PR, Cheung AY, Nguyen SA, White DR, Weber PC
Int J Pediatr Otorhinolaryngol 2018 Sep;112:109-112. Epub 2018 Jun 12 doi: 10.1016/j.ijporl.2018.06.017. PMID: 30055718
Fascin and the differential diagnosis of childhood histiocytic lesions.
Jaffe R, DeVaughn D, Langhoff E
Pediatr Dev Pathol 1998 May-Jun;1(3):216-21. doi: 10.1007/s100249900029. PMID: 10463281

Recent clinical studies

Etiology

Children's Oncology Group's 2023 blueprint for research: Epidemiology.
Lupo PJ, Marcotte EL, Scheurer ME, Poynter JN, Spector LG; COG Epidemiology Committee
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30566. Epub 2023 Jul 14 doi: 10.1002/pbc.30566. PMID: 37449937Free PMC Article
Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study.
van Atteveld JE, de Winter DTC, Pluimakers VG, Fiocco M, Nievelstein RAJ, Hobbelink MGG, de Vries ACH, Loonen JJ, van Dulmen-den Broeder E, van der Pal HJ, Pluijm SMF, Kremer LCM, Ronckers CM, van der Heiden-van der Loo M, Versluijs AB, Louwerens M, Bresters D, van Santen HM, Olsson DS, Hoefer I, van den Berg SAA, den Hartogh J, Tissing WJE, Neggers SJCMM, van den Heuvel-Eibrink MM; Dutch LATER study group
Lancet Diabetes Endocrinol 2023 Jan;11(1):21-32. Epub 2022 Dec 10 doi: 10.1016/S2213-8587(22)00286-8. PMID: 36513116
Histiocytic Disorders of Childhood.
Eckstein OS, Picarsic J, Allen CE
Pediatr Rev 2022 Oct 1;43(10):561-571. doi: 10.1542/pir.2021-005367. PMID: 36180546
Langerhans cell histiocytosis and associated malignancies: A retrospective analysis of 270 patients.
Bagnasco F, Zimmermann SY, Egeler RM, Nanduri VR, Cammarata B, Donadieu J, Lehrnbecher T, Haupt R
Eur J Cancer 2022 Sep;172:138-145. Epub 2022 Jun 27 doi: 10.1016/j.ejca.2022.03.036. PMID: 35772351
High levels of plasma interleukin-17A are associated with severe neurological sequelae in Langerhans cell histiocytosis.
Ismail MB, Åkefeldt SO, Lourda M, Gavhed D, Aricò M, Henter JI, Delprat C, Valentin H
Cytokine 2020 Feb;126:154877. Epub 2019 Oct 16 doi: 10.1016/j.cyto.2019.154877. PMID: 31629106

Diagnosis

Histiocytic Disorders of Childhood.
Eckstein OS, Picarsic J, Allen CE
Pediatr Rev 2022 Oct 1;43(10):561-571. doi: 10.1542/pir.2021-005367. PMID: 36180546
Langerhans cell histiocytosis and associated malignancies: A retrospective analysis of 270 patients.
Bagnasco F, Zimmermann SY, Egeler RM, Nanduri VR, Cammarata B, Donadieu J, Lehrnbecher T, Haupt R
Eur J Cancer 2022 Sep;172:138-145. Epub 2022 Jun 27 doi: 10.1016/j.ejca.2022.03.036. PMID: 35772351
Neuroendocrine manifestations of Langerhans cell histiocytosis.
Yavropoulou MP, Tsoli M, Kaltsas G
Handb Clin Neurol 2021;181:127-135. doi: 10.1016/B978-0-12-820683-6.00009-9. PMID: 34238452
Langerhans Cell Histiocytosis Presenting as Progressively Worsening Neck Pain: A Case Report With a Review of Literature.
Krishnan N, Zuberi L, Shukri A, Gopinath A, Haymes D
J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619886757. doi: 10.1177/2324709619886757. PMID: 31694399Free PMC Article
Juvenile xanthogranuloma.
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB
J Am Acad Dermatol 1997 Mar;36(3 Pt 1):355-67; quiz 368-9. doi: 10.1016/s0190-9622(97)80207-1. PMID: 9091465

Therapy

Macrophage activation syndrome in juvenile idiopathic arthritis.
Cortis E, Insalaco A
Acta Paediatr Suppl 2006 Jul;95(452):38-41. doi: 10.1111/j.1651-2227.2006.tb02414.x. PMID: 16801165

Prognosis

High incidence of hearing loss in long-term survivors of multisystem Langerhans cell histiocytosis.
Nanduri V, Tatevossian R, Sirimanna T
Pediatr Blood Cancer 2010 Mar;54(3):449-53. doi: 10.1002/pbc.22186. PMID: 19813249
A case of Langerhans cell histiocytosis presented with pneumothorax.
Gunes T, Koklu E, Ozturk MA, Patiroglu T, Patiroglu T, Karakukcu M
J Pediatr Hematol Oncol 2007 Jan;29(1):60-2. doi: 10.1097/MPH.0b013e318030abfd. PMID: 17230069
Macrophage activation syndrome in juvenile idiopathic arthritis.
Cortis E, Insalaco A
Acta Paediatr Suppl 2006 Jul;95(452):38-41. doi: 10.1111/j.1651-2227.2006.tb02414.x. PMID: 16801165
Dynamic endocrine testing and magnetic resonance imaging in the long-term follow-up of childhood langerhans cell histiocytosis.
Maghnie M, Bossi G, Klersy C, Cosi G, Genovese E, Aricò M
J Clin Endocrinol Metab 1998 Sep;83(9):3089-94. doi: 10.1210/jcem.83.9.5108. PMID: 9745408
Juvenile xanthogranuloma.
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB
J Am Acad Dermatol 1997 Mar;36(3 Pt 1):355-67; quiz 368-9. doi: 10.1016/s0190-9622(97)80207-1. PMID: 9091465

Clinical prediction guides

Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study.
van Atteveld JE, de Winter DTC, Pluimakers VG, Fiocco M, Nievelstein RAJ, Hobbelink MGG, de Vries ACH, Loonen JJ, van Dulmen-den Broeder E, van der Pal HJ, Pluijm SMF, Kremer LCM, Ronckers CM, van der Heiden-van der Loo M, Versluijs AB, Louwerens M, Bresters D, van Santen HM, Olsson DS, Hoefer I, van den Berg SAA, den Hartogh J, Tissing WJE, Neggers SJCMM, van den Heuvel-Eibrink MM; Dutch LATER study group
Lancet Diabetes Endocrinol 2023 Jan;11(1):21-32. Epub 2022 Dec 10 doi: 10.1016/S2213-8587(22)00286-8. PMID: 36513116
Nutritional screening and assessment of paediatric cancer patients: A quality improvement project (baseline results).
Glatt D, Hughes C, McCarthy O, O'Shea F, Brougham MFH, Wilson DC, Revuelta Iniesta R
Clin Nutr ESPEN 2020 Aug;38:242-252. Epub 2020 Apr 27 doi: 10.1016/j.clnesp.2020.04.003. PMID: 32690165
Long term morbidity and health related quality of life after multi-system Langerhans cell histiocytosis.
Nanduri VR, Pritchard J, Levitt G, Glaser AW
Eur J Cancer 2006 Oct;42(15):2563-9. Epub 2006 Sep 7 doi: 10.1016/j.ejca.2006.05.031. PMID: 16959486
Macrophage activation syndrome in juvenile idiopathic arthritis.
Cortis E, Insalaco A
Acta Paediatr Suppl 2006 Jul;95(452):38-41. doi: 10.1111/j.1651-2227.2006.tb02414.x. PMID: 16801165
Dynamic endocrine testing and magnetic resonance imaging in the long-term follow-up of childhood langerhans cell histiocytosis.
Maghnie M, Bossi G, Klersy C, Cosi G, Genovese E, Aricò M
J Clin Endocrinol Metab 1998 Sep;83(9):3089-94. doi: 10.1210/jcem.83.9.5108. PMID: 9745408

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