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Childhood Brain Oligodendroglioma

MedGen UID:
859268
•Concept ID:
C3899674
•
Neoplastic Process

Definition

An oligodendroglioma that arises from the brain and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Brain Oligodendroglioma

Professional guidelines

PubMed

Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.
Dodgshun AJ, SantaCruz N, Hwang J, Ramkissoon SH, Malkin H, Bergthold G, Manley P, Chi S, MacGregor D, Goumnerova L, Sullivan M, Ligon K, Beroukhim R, Herrington B, Kieran MW, Hansford JR, Bandopadhayay P
J Neurooncol 2016 Jun;128(2):293-302. Epub 2016 Mar 19 doi: 10.1007/s11060-016-2109-x. PMID: 26994902
The impact of technical adjuncts in the surgical management of cerebral hemispheric low-grade gliomas of childhood.
Berger MS
J Neurooncol 1996 May-Jun;28(2-3):129-55. doi: 10.1007/BF00250195. PMID: 8832458
Role of radiation therapy in the management of neoplasms of the central nervous system.
Mayer EG, Boone ML, Aristizabal SA
Adv Neurol 1976;15:201-20. PMID: 180777

Recent clinical studies

Etiology

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363
Malignant hemispheric tumors in childhood.
Hoppe-Hirsch E, Hirsch JF, Lellouch-Tubiana A, Pierre-Kahn A, Sainte-Rose C, Renier D
Childs Nerv Syst 1993 Jun;9(3):131-5. doi: 10.1007/BF00272260. PMID: 8397066
Oligodendroglioma of the posterior fossa in childhood.
Packer RJ, Sutton LN, Rorke LB, Zimmerman RA, Littman P, Bruce DA, Schut L
Cancer 1985 Jul 1;56(1):195-9. doi: 10.1002/1097-0142(19850701)56:1<195::aid-cncr2820560133>3.0.co;2-3. PMID: 4005789
Childhood brain tumors presenting as chronic uncontrolled focal seizure disorders.
Blume WT, Girvin JP, Kaufmann JC
Ann Neurol 1982 Dec;12(6):538-41. doi: 10.1002/ana.410120606. PMID: 6297372

Diagnosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
CT and MRI aspects of supratentorial hemispheric tumors of childhood and adolescence.
Finizio FS
Childs Nerv Syst 1995 Oct;11(10):559-67. doi: 10.1007/BF00300993. PMID: 8556721
Malignant hemispheric tumors in childhood.
Hoppe-Hirsch E, Hirsch JF, Lellouch-Tubiana A, Pierre-Kahn A, Sainte-Rose C, Renier D
Childs Nerv Syst 1993 Jun;9(3):131-5. doi: 10.1007/BF00272260. PMID: 8397066
Childhood brain tumors presenting as chronic uncontrolled focal seizure disorders.
Blume WT, Girvin JP, Kaufmann JC
Ann Neurol 1982 Dec;12(6):538-41. doi: 10.1002/ana.410120606. PMID: 6297372

Therapy

Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis.
Manoharan N, Ajuyah P, Senapati A, Wong M, Mullins A, Rodriguez M, Doyle H, McCowage G, Lau LMS, Ekert PG, Ziegler DS
Acta Neuropathol Commun 2021 Sep 7;9(1):147. doi: 10.1186/s40478-021-01248-w. PMID: 34493325Free PMC Article
Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.
Dubbink HJ, Atmodimedjo PN, Kros JM, French PJ, Sanson M, Idbaih A, Wesseling P, Enting R, Spliet W, Tijssen C, Dinjens WN, Gorlia T, van den Bent MJ
Neuro Oncol 2016 Mar;18(3):388-400. Epub 2015 Sep 9 doi: 10.1093/neuonc/nov182. PMID: 26354927Free PMC Article
Anaplastic oligodendroglioma after childhood acute lymphoblastic leukemia: chemotherapy and autologous peripheral blood stem cell transplantation.
Hah JO
J Pediatr Hematol Oncol 2008 Oct;30(10):764-7. doi: 10.1097/MPH.0b013e31817e4a55. PMID: 19011476
Extracranial relapse of an anaplastic oligodendroglioma in an adolescent: case report and review of the literature.
Bruggers C, White K, Zhou H, Chen Z
J Pediatr Hematol Oncol 2007 May;29(5):319-22. doi: 10.1097/MPH.0b013e318054756e. PMID: 17483710
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.
Massimino M, Gandola L, Luksch R, Spreafico F, Riva D, Solero C, Giangaspero F, Locatelli F, Podda M, Bozzi F, Pignoli E, Collini P, Cefalo G, Zecca M, Casanova M, Ferrari A, Terenziani M, Meazza C, Polastri D, Scaramuzza D, Ravagnani F, Fossati-Bellani F
Neuro Oncol 2005 Jan;7(1):41-8. doi: 10.1215/S1152851704000304. PMID: 15701281Free PMC Article

Prognosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
CT and MRI aspects of supratentorial hemispheric tumors of childhood and adolescence.
Finizio FS
Childs Nerv Syst 1995 Oct;11(10):559-67. doi: 10.1007/BF00300993. PMID: 8556721
Oligodendroglioma in childhood.
Wang KC, Chi JG, Cho BK
J Korean Med Sci 1993 Apr;8(2):110-6. doi: 10.3346/jkms.1993.8.2.110. PMID: 8397926Free PMC Article
Oligodendroglioma of the posterior fossa in childhood.
Packer RJ, Sutton LN, Rorke LB, Zimmerman RA, Littman P, Bruce DA, Schut L
Cancer 1985 Jul 1;56(1):195-9. doi: 10.1002/1097-0142(19850701)56:1<195::aid-cncr2820560133>3.0.co;2-3. PMID: 4005789

Clinical prediction guides

Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
CT and MRI aspects of supratentorial hemispheric tumors of childhood and adolescence.
Finizio FS
Childs Nerv Syst 1995 Oct;11(10):559-67. doi: 10.1007/BF00300993. PMID: 8556721
Oligodendroglioma in childhood.
Wang KC, Chi JG, Cho BK
J Korean Med Sci 1993 Apr;8(2):110-6. doi: 10.3346/jkms.1993.8.2.110. PMID: 8397926Free PMC Article
Malignant hemispheric tumors in childhood.
Hoppe-Hirsch E, Hirsch JF, Lellouch-Tubiana A, Pierre-Kahn A, Sainte-Rose C, Renier D
Childs Nerv Syst 1993 Jun;9(3):131-5. doi: 10.1007/BF00272260. PMID: 8397066

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