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Elevated tissue non-specific alkaline phosphatase

MedGen UID:
866885
•Concept ID:
C4021240
•
Finding
Synonyms: Elevated alkaline phosphatase, liver/bone/kidney; Elevated tissue non-specific ALP
 
HPO: HP:0010679

Definition

An abnormally increased level of alkaline phosphatase, tissue-nonspecific isozyme in the blood. [from HPO]

Professional guidelines

PubMed

Serological biomarkers for management of primary sclerosing cholangitis.
Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Hypophosphatasia: Canadian update on diagnosis and management.
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507

Recent clinical studies

Etiology

Rare Genetic Developmental Disabilities: Mabry Syndrome (MIM 239300) Index Cases and Glycophosphatidylinositol (GPI) Disorders.
Thompson MD, Knaus A
Genes (Basel) 2024 May 14;15(5) doi: 10.3390/genes15050619. PMID: 38790248Free PMC Article
Detection of hypophosphatasia in hospitalised adults in rheumatology and internal medicine departments: a multicentre study over 10 years.
Larid G, Vix J, Preuss P, Robin F, Tison A, Delaveau C, Krajewski F, Bouvard B, Chu Miow Lin D, Guggenbuhl P, Maugars Y, Saraux A, Debiais F
RMD Open 2024 Apr 4;10(2) doi: 10.1136/rmdopen-2024-004316. PMID: 38580346Free PMC Article
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells.
Shaver M, Gomez K, Kaiser K, Hutcheson JD
BMC Mol Cell Biol 2024 Mar 14;25(1):8. doi: 10.1186/s12860-024-00504-w. PMID: 38486163Free PMC Article
Hypophosphatasia: Biochemical hallmarks validate the expanded pediatric clinical nosology.
Whyte MP, Coburn SP, Ryan LM, Ericson KL, Zhang F
Bone 2018 May;110:96-106. Epub 2018 Jan 31 doi: 10.1016/j.bone.2018.01.022. PMID: 29360619
Long-term follow-up of bone mineral density in childhood hypophosphatasia.
Girschick HJ, Haubitz I, Hiort O, Schneider P
Joint Bone Spine 2007 May;74(3):263-9. Epub 2007 Mar 15 doi: 10.1016/j.jbspin.2006.06.017. PMID: 17420150

Diagnosis

Hypophosphatasia: presentation and response to asfotase alfa.
Alsarraf F, Ali DS, Almonaei K, Al-Alwani H, Khan AA, Brandi ML
Osteoporos Int 2024 Apr;35(4):717-725. Epub 2023 Nov 23 doi: 10.1007/s00198-023-06943-z. PMID: 37993691
Serological biomarkers for management of primary sclerosing cholangitis.
Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Hypophosphatasia: Canadian update on diagnosis and management.
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507
Clinical Forms and Animal Models of Hypophosphatasia.
Salles JP
Subcell Biochem 2015;76:3-24. doi: 10.1007/978-94-017-7197-9_1. PMID: 26219704
A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection.
Hickey AJ, Gounder L, Moosa MY, Drain PK
BMC Infect Dis 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103Free PMC Article

Therapy

Hypophosphatasia: presentation and response to asfotase alfa.
Alsarraf F, Ali DS, Almonaei K, Al-Alwani H, Khan AA, Brandi ML
Osteoporos Int 2024 Apr;35(4):717-725. Epub 2023 Nov 23 doi: 10.1007/s00198-023-06943-z. PMID: 37993691
Hypophosphatasia: Canadian update on diagnosis and management.
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507
Identifying early pathogenic events during vascular calcification in uremic rats.
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316
Long-term follow-up of bone mineral density in childhood hypophosphatasia.
Girschick HJ, Haubitz I, Hiort O, Schneider P
Joint Bone Spine 2007 May;74(3):263-9. Epub 2007 Mar 15 doi: 10.1016/j.jbspin.2006.06.017. PMID: 17420150
Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.
Waymire KG, Mahuren JD, Jaje JM, Guilarte TR, Coburn SP, MacGregor GR
Nat Genet 1995 Sep;11(1):45-51. doi: 10.1038/ng0995-45. PMID: 7550313

Prognosis

Serological biomarkers for management of primary sclerosing cholangitis.
Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Clinical Forms and Animal Models of Hypophosphatasia.
Salles JP
Subcell Biochem 2015;76:3-24. doi: 10.1007/978-94-017-7197-9_1. PMID: 26219704
Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients.
Kumarasinghe DD, Sullivan T, Kuliwaba JS, Fazzalari NL, Atkins GJ
Osteoarthritis Cartilage 2012 Nov;20(11):1357-66. Epub 2012 Jul 20 doi: 10.1016/j.joca.2012.07.005. PMID: 22820497
Long-term follow-up of bone mineral density in childhood hypophosphatasia.
Girschick HJ, Haubitz I, Hiort O, Schneider P
Joint Bone Spine 2007 May;74(3):263-9. Epub 2007 Mar 15 doi: 10.1016/j.jbspin.2006.06.017. PMID: 17420150

Clinical prediction guides

Serological biomarkers for management of primary sclerosing cholangitis.
Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.
Nwafor DC, Chakraborty S, Brichacek AL, Jun S, Gambill CA, Wang W, Engler-Chiurazzi EB, Dakhlallah D, Pinkerton AB, Millán JL, Benkovic SA, Brown CM
Brain Behav Immun 2020 Feb;84:115-131. Epub 2019 Nov 25 doi: 10.1016/j.bbi.2019.11.016. PMID: 31778743Free PMC Article
Hypophosphatasia: Canadian update on diagnosis and management.
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507
FGF23 and its role in X-linked hypophosphatemia-related morbidity.
Beck-Nielsen SS, Mughal Z, Haffner D, Nilsson O, Levtchenko E, Ariceta G, de Lucas Collantes C, Schnabel D, Jandhyala R, Mäkitie O
Orphanet J Rare Dis 2019 Feb 26;14(1):58. doi: 10.1186/s13023-019-1014-8. PMID: 30808384Free PMC Article
Identifying early pathogenic events during vascular calcification in uremic rats.
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316

Recent systematic reviews

A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection.
Hickey AJ, Gounder L, Moosa MY, Drain PK
BMC Infect Dis 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103Free PMC Article

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