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Increased hemoglobin oxygen affinity

MedGen UID:
867285
•Concept ID:
C4021647
•
Finding
Synonyms: Increased haemoglobin O2 affinity; Increased Hb O2 affinity; Increased Hb oxygen affinity; Increased hemoglobin O2 affinity
 
HPO: HP:0004825

Definition

An abnormal increase in the binding affinity of hemoglobin for oxygen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased hemoglobin oxygen affinity

Conditions with this feature

Hemoglobin--variants for which the chain carrying the mutation is unknown or uncertain
MedGen UID:
333610
•Concept ID:
C1840647
•
Disease or Syndrome
See: Condition Record
Hemoglobin--variants for which the chain carrying the mutation is unknown or uncertain

Professional guidelines

PubMed

Potential role of blood constituents in pain-relief associated with fibromyalgia treatment with extremely low magnetic field: Spectroscopic investigation.
Mahmoud SS, Ibrahim AA, Aly EM, Ali MA
Spectrochim Acta A Mol Biomol Spectrosc 2023 Jan 5;284:121795. Epub 2022 Aug 31 doi: 10.1016/j.saa.2022.121795. PMID: 36063735

Recent clinical studies

Etiology

The effect of N,N'-p-phenylenedimaleimide (PMD) on deoxygenation-induced K loss in sickle erythrocytes.
Wall SN, Berkowitz LR
Am J Med Sci 1987 Aug;294(2):105-9. doi: 10.1097/00000441-198708000-00009. PMID: 3631120
Prevention of increased hemoglobin-oxygen affinity in open-heart operations with inosine-phosphate-pyruvate solution.
Giannelli S Jr, McKenna JP, Bordiuk JM, Miller LD, Jerome CR
Ann Thorac Surg 1976 May;21(5):386-96. doi: 10.1016/s0003-4975(10)63886-6. PMID: 1267522
Phosphate depletion and repletion: relation to parenteral nutrition and oxygen transport.
Sheldon GF, Grzyb S
Ann Surg 1975 Dec;182(6):683-9. doi: 10.1097/00000658-197512000-00004. PMID: 811182Free PMC Article

Diagnosis

The dependence of maximum oxygen uptake and utilization (V̇O(2) max) on hemoglobin-oxygen affinity and altitude.
Webb KL, Joyner MJ, Wiggins CC, Secomb TW, Roy TK
Physiol Rep 2023 Sep;11(17):e15806. doi: 10.14814/phy2.15806. PMID: 37653565Free PMC Article
Potential role of blood constituents in pain-relief associated with fibromyalgia treatment with extremely low magnetic field: Spectroscopic investigation.
Mahmoud SS, Ibrahim AA, Aly EM, Ali MA
Spectrochim Acta A Mol Biomol Spectrosc 2023 Jan 5;284:121795. Epub 2022 Aug 31 doi: 10.1016/j.saa.2022.121795. PMID: 36063735

Therapy

Prevention of increased hemoglobin-oxygen affinity in open-heart operations with inosine-phosphate-pyruvate solution.
Giannelli S Jr, McKenna JP, Bordiuk JM, Miller LD, Jerome CR
Ann Thorac Surg 1976 May;21(5):386-96. doi: 10.1016/s0003-4975(10)63886-6. PMID: 1267522
Phosphate depletion and repletion: relation to parenteral nutrition and oxygen transport.
Sheldon GF, Grzyb S
Ann Surg 1975 Dec;182(6):683-9. doi: 10.1097/00000658-197512000-00004. PMID: 811182Free PMC Article
Reduced red cell glycolysis, 2, 3-diphosphoglycerate and adenosine triphosphate concentration, and increased hemoglobin-oxygen affinity caused by hypophosphatemia.
Lichtman MA, Miller DR, Cohen J, Waterhouse C
Ann Intern Med 1971 Apr;74(4):562-8. doi: 10.7326/0003-4819-74-4-562. PMID: 4994546

Prognosis

The dependence of maximum oxygen uptake and utilization (V̇O(2) max) on hemoglobin-oxygen affinity and altitude.
Webb KL, Joyner MJ, Wiggins CC, Secomb TW, Roy TK
Physiol Rep 2023 Sep;11(17):e15806. doi: 10.14814/phy2.15806. PMID: 37653565Free PMC Article
Prevention of increased hemoglobin-oxygen affinity in open-heart operations with inosine-phosphate-pyruvate solution.
Giannelli S Jr, McKenna JP, Bordiuk JM, Miller LD, Jerome CR
Ann Thorac Surg 1976 May;21(5):386-96. doi: 10.1016/s0003-4975(10)63886-6. PMID: 1267522
Phosphate depletion and repletion: relation to parenteral nutrition and oxygen transport.
Sheldon GF, Grzyb S
Ann Surg 1975 Dec;182(6):683-9. doi: 10.1097/00000658-197512000-00004. PMID: 811182Free PMC Article

Clinical prediction guides

The dependence of maximum oxygen uptake and utilization (V̇O(2) max) on hemoglobin-oxygen affinity and altitude.
Webb KL, Joyner MJ, Wiggins CC, Secomb TW, Roy TK
Physiol Rep 2023 Sep;11(17):e15806. doi: 10.14814/phy2.15806. PMID: 37653565Free PMC Article
Potential role of blood constituents in pain-relief associated with fibromyalgia treatment with extremely low magnetic field: Spectroscopic investigation.
Mahmoud SS, Ibrahim AA, Aly EM, Ali MA
Spectrochim Acta A Mol Biomol Spectrosc 2023 Jan 5;284:121795. Epub 2022 Aug 31 doi: 10.1016/j.saa.2022.121795. PMID: 36063735

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