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Abnormal glial cell morphology

MedGen UID:
867607
•Concept ID:
C4021993
•
Finding
Synonym: Abnormality of the glial cells
 
HPO: HP:0100705

Definition

An abnormality of the glia cell. [from HPO]

Professional guidelines

PubMed

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity.
van Rensburg SJ, van Toorn R, Erasmus RT, Hattingh C, Johannes C, Moremi KE, Kemp MC, Engel-Hills P, Kotze MJ
Metab Brain Dis 2021 Aug;36(6):1151-1167. Epub 2021 Apr 28 doi: 10.1007/s11011-021-00711-w. PMID: 33909200
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797
Diabetic gastroparesis: functional/morphologic background, diagnosis, and treatment options.
Horváth VJ, Izbéki F, Lengyel C, Kempler P, Várkonyi T
Curr Diab Rep 2014;14(9):527. doi: 10.1007/s11892-014-0527-8. PMID: 25005121

Recent clinical studies

Etiology

Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.
Taddei RN, Perbet R, Mate de Gerando A, Wiedmer AE, Sanchez-Mico M, Connors Stewart T, Gaona A, Melloni A, Amaral AC, Duff K, Frosch MP, Gómez-Isla T
JAMA Neurol 2023 Nov 1;80(11):1209-1221. doi: 10.1001/jamaneurol.2023.3530. PMID: 37812432Free PMC Article
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P
Cell Stem Cell 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007. PMID: 35803230Free PMC Article
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes.
Jin X, Simmons SK, Guo A, Shetty AS, Ko M, Nguyen L, Jokhi V, Robinson E, Oyler P, Curry N, Deangeli G, Lodato S, Levin JZ, Regev A, Zhang F, Arlotta P
Science 2020 Nov 27;370(6520) doi: 10.1126/science.aaz6063. PMID: 33243861Free PMC Article
Glial cells in schizophrenia: a unified hypothesis.
Dietz AG, Goldman SA, Nedergaard M
Lancet Psychiatry 2020 Mar;7(3):272-281. Epub 2019 Nov 6 doi: 10.1016/S2215-0366(19)30302-5. PMID: 31704113Free PMC Article
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes.
Nasrabady SE, Rizvi B, Goldman JE, Brickman AM
Acta Neuropathol Commun 2018 Mar 2;6(1):22. doi: 10.1186/s40478-018-0515-3. PMID: 29499767Free PMC Article

Diagnosis

Congenital Opticmeningoceles.
Cruz AAV, Akaishi PMS, Bernardini F, Chahud F
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):e109-e111. doi: 10.1097/IOP.0000000000001864. PMID: 33229952
Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.
Christian KM, Song H, Ming GL
Annu Rev Neurosci 2019 Jul 8;42:249-269. doi: 10.1146/annurev-neuro-080317-062231. PMID: 31283901Free PMC Article
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Central respiratory chemoreception.
Guyenet PG, Stornetta RL, Bayliss DA
J Comp Neurol 2010 Oct 1;518(19):3883-906. doi: 10.1002/cne.22435. PMID: 20737591Free PMC Article
Multiple system atrophy.
Wenning GK, Geser F
Rev Neurol (Paris) 2003 May;159(5 Pt 2):3S31-8. PMID: 12773886

Therapy

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
J Neuroinflammation 2021 Jun 11;18(1):131. doi: 10.1186/s12974-021-02182-3. PMID: 34116706Free PMC Article
Microglia in depression: current perspectives.
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
Drug-Induced Demyelinating Neuropathies.
Niimi N, Takaku S, Yako H, Sango K
Adv Exp Med Biol 2019;1190:357-369. doi: 10.1007/978-981-32-9636-7_23. PMID: 31760656
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797
Molecular dissection of reactive astrogliosis and glial scar formation.
Sofroniew MV
Trends Neurosci 2009 Dec;32(12):638-47. Epub 2009 Sep 24 doi: 10.1016/j.tins.2009.08.002. PMID: 19782411Free PMC Article

Prognosis

Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797
Glial pathology in bipolar disorder: potential therapeutic implications.
Dong XH, Zhen XC
CNS Neurosci Ther 2015 May;21(5):393-7. Epub 2015 Mar 9 doi: 10.1111/cns.12390. PMID: 25753128Free PMC Article
Glutamate uptake.
Danbolt NC
Prog Neurobiol 2001 Sep;65(1):1-105. doi: 10.1016/s0301-0082(00)00067-8. PMID: 11369436

Clinical prediction guides

Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms.
Xie M, Pallegar PN, Parusel S, Nguyen AT, Wu LJ
Mol Neurodegener 2023 Oct 19;18(1):75. doi: 10.1186/s13024-023-00665-w. PMID: 37858176Free PMC Article
Microglia in animal models of autism spectrum disorders.
Andoh M, Ikegaya Y, Koyama R
Prog Mol Biol Transl Sci 2020;173:239-273. Epub 2020 May 8 doi: 10.1016/bs.pmbts.2020.04.012. PMID: 32711812
Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease.
Soret R, Schneider S, Bernas G, Christophers B, Souchkova O, Charrier B, Righini-Grunder F, Aspirot A, Landry M, Kembel SW, Faure C, Heuckeroth RO, Pilon N
Gastroenterology 2020 Nov;159(5):1824-1838.e17. Epub 2020 Jul 17 doi: 10.1053/j.gastro.2020.07.018. PMID: 32687927
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Neurobiology of premature brain injury.
Salmaso N, Jablonska B, Scafidi J, Vaccarino FM, Gallo V
Nat Neurosci 2014 Mar;17(3):341-6. Epub 2014 Feb 25 doi: 10.1038/nn.3604. PMID: 24569830Free PMC Article

Recent systematic reviews

Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.
Yamamoto M, Sakai M, Yu Z, Nakanishi M, Yoshii H
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115750. PMID: 38891940Free PMC Article
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.
Hagbohm C, Ouellette R, Flanagan EP, Jonsson DI, Piehl F, Banwell B, Wickström R, Iacobaeus E, Granberg T, Ineichen BV
Eur J Neurol 2024 Jul;31(7):e16284. Epub 2024 Mar 20 doi: 10.1111/ene.16284. PMID: 38506182Free PMC Article
Brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS): new cases, systematic literature review, and associations with CSF1R-ALSP.
Dulski J, Souza J, Santos ML, Wszolek ZK
Orphanet J Rare Dis 2023 Jun 22;18(1):160. doi: 10.1186/s13023-023-02772-9. PMID: 37349768Free PMC Article
Clinical relevance of BRAF status in glial and glioneuronal tumors: A systematic review.
Sugiura Y, Nagaishi M
J Clin Neurosci 2019 Aug;66:196-201. Epub 2019 May 27 doi: 10.1016/j.jocn.2019.05.014. PMID: 31147232
Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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