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Cerebral inclusion bodies

MedGen UID:
867759
•Concept ID:
C4022149
•
Disease or Syndrome
HPO: HP:0100314

Definition

Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain. [from HPO]

Professional guidelines

PubMed

Pharmacological Management of Apathy in Dementia.
Azhar L, Kusumo RW, Marotta G, Lanctôt KL, Herrmann N
CNS Drugs 2022 Feb;36(2):143-165. Epub 2022 Jan 10 doi: 10.1007/s40263-021-00883-0. PMID: 35006557
Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL
Stroke 2019 Dec;50(12):e344-e418. Epub 2019 Oct 30 doi: 10.1161/STR.0000000000000211. PMID: 31662037
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB
Neurology 2005 Dec 27;65(12):1863-72. Epub 2005 Oct 19 doi: 10.1212/01.wnl.0000187889.17253.b1. PMID: 16237129

Recent clinical studies

Etiology

Trinucleotide repeat disorders.
Den Dunnen WFA
Handb Clin Neurol 2017;145:383-391. doi: 10.1016/B978-0-12-802395-2.00027-4. PMID: 28987184
Functional neuroanatomy of the basal ganglia.
Lanciego JL, Luquin N, Obeso JA
Cold Spring Harb Perspect Med 2012 Dec 1;2(12):a009621. doi: 10.1101/cshperspect.a009621. PMID: 23071379Free PMC Article
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.
Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM
Neuron 2002 May 16;34(4):521-33. doi: 10.1016/s0896-6273(02)00682-7. PMID: 12062037
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
Hughes AJ, Daniel SE, Kilford L, Lees AJ
J Neurol Neurosurg Psychiatry 1992 Mar;55(3):181-4. doi: 10.1136/jnnp.55.3.181. PMID: 1564476Free PMC Article
The gangliosidoses.
Volk BW, Adachi M, Schneck L
Hum Pathol 1975 Sep;6(5):555-69. doi: 10.1016/s0046-8177(75)80041-4. PMID: 170187

Diagnosis

Structures of α-synuclein filaments from multiple system atrophy.
Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
Nature 2020 Sep;585(7825):464-469. Epub 2020 May 27 doi: 10.1038/s41586-020-2317-6. PMID: 32461689Free PMC Article
Frontotemporal dementia.
Graff-Radford NR, Woodruff BK
Semin Neurol 2007 Feb;27(1):48-57. doi: 10.1055/s-2006-956755. PMID: 17226741
Staging of brain pathology related to sporadic Parkinson's disease.
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E
Neurobiol Aging 2003 Mar-Apr;24(2):197-211. doi: 10.1016/s0197-4580(02)00065-9. PMID: 12498954
Multiple system atrophy.
Quinn N, Wenning G
Curr Opin Neurol 1995 Aug;8(4):323-6. doi: 10.1097/00019052-199508000-00013. PMID: 7582051
The gangliosidoses.
Volk BW, Adachi M, Schneck L
Hum Pathol 1975 Sep;6(5):555-69. doi: 10.1016/s0046-8177(75)80041-4. PMID: 170187

Therapy

Pharmacological Management of Apathy in Dementia.
Azhar L, Kusumo RW, Marotta G, Lanctôt KL, Herrmann N
CNS Drugs 2022 Feb;36(2):143-165. Epub 2022 Jan 10 doi: 10.1007/s40263-021-00883-0. PMID: 35006557
Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL
Stroke 2019 Dec;50(12):e344-e418. Epub 2019 Oct 30 doi: 10.1161/STR.0000000000000211. PMID: 31662037
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS
Neuron 2019 Aug 21;103(4):627-641.e7. Epub 2019 Jun 26 doi: 10.1016/j.neuron.2019.05.035. PMID: 31255487Free PMC Article
Two hundred steps.
Drew L
Nature 2016 Oct 27;538(7626):S2-S3. doi: 10.1038/538S2a. PMID: 27783577
The Lewy body in Parkinson's disease and related neurodegenerative disorders.
Wakabayashi K, Tanji K, Odagiri S, Miki Y, Mori F, Takahashi H
Mol Neurobiol 2013 Apr;47(2):495-508. Epub 2012 May 24 doi: 10.1007/s12035-012-8280-y. PMID: 22622968

Prognosis

Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.
Sengupta U, Kayed R
Prog Neurobiol 2022 Jul;214:102270. Epub 2022 Apr 18 doi: 10.1016/j.pneurobio.2022.102270. PMID: 35447272
Alpha-synucleinopathies.
Alafuzoff I, Hartikainen P
Handb Clin Neurol 2017;145:339-353. doi: 10.1016/B978-0-12-802395-2.00024-9. PMID: 28987181
A systematic review of potential long-term effects of sport-related concussion.
Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL
Br J Sports Med 2017 Jun;51(12):969-977. Epub 2017 Apr 28 doi: 10.1136/bjsports-2017-097791. PMID: 28455362Free PMC Article
Stages in the development of Parkinson's disease-related pathology.
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K
Cell Tissue Res 2004 Oct;318(1):121-34. Epub 2004 Aug 24 doi: 10.1007/s00441-004-0956-9. PMID: 15338272
Staging of brain pathology related to sporadic Parkinson's disease.
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E
Neurobiol Aging 2003 Mar-Apr;24(2):197-211. doi: 10.1016/s0197-4580(02)00065-9. PMID: 12498954

Clinical prediction guides

Skin biopsy and neuronal intranuclear inclusion disease.
Ren X, Tan D, Deng J, Wang Z, Hong D
J Dermatol 2023 Nov;50(11):1367-1372. Epub 2023 Sep 18 doi: 10.1111/1346-8138.16966. PMID: 37718652
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease.
Sone J, Mitsuhashi S, Fujita A, Mizuguchi T, Hamanaka K, Mori K, Koike H, Hashiguchi A, Takashima H, Sugiyama H, Kohno Y, Takiyama Y, Maeda K, Doi H, Koyano S, Takeuchi H, Kawamoto M, Kohara N, Ando T, Ieda T, Kita Y, Kokubun N, Tsuboi Y, Katoh K, Kino Y, Katsuno M, Iwasaki Y, Yoshida M, Tanaka F, Suzuki IK, Frith MC, Matsumoto N, Sobue G
Nat Genet 2019 Aug;51(8):1215-1221. Epub 2019 Jul 22 doi: 10.1038/s41588-019-0459-y. PMID: 31332381
Immunohistochemical localization of spatacsin in α-synucleinopathies.
Kuru S, Yoshida M, Tatsumi S, Mimuro M
Neuropathology 2014 Apr;34(2):135-9. Epub 2013 Sep 22 doi: 10.1111/neup.12069. PMID: 24112408
Polyglutamine pathogenesis.
Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC Jr, Cooper JK, Sharp AH, Margolis RL, Borchelt DR
Philos Trans R Soc Lond B Biol Sci 1999 Jun 29;354(1386):1005-11. doi: 10.1098/rstb.1999.0452. PMID: 10434299Free PMC Article
Dementia and Parkinson's disease.
Gibb WR
Br J Psychiatry 1989 May;154:596-614. doi: 10.1192/bjp.154.5.596. PMID: 2557109

Recent systematic reviews

Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.
Donaghy PC, Carrarini C, Ferreira D, Habich A, Aarsland D, Babiloni C, Bayram E, Kane JP, Lewis SJ, Pilotto A, Thomas AJ, Bonanni L; Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment Lewy Body Dementias Prodromal Working Group
Alzheimers Dement 2023 Jul;19(7):3186-3202. Epub 2023 Apr 24 doi: 10.1002/alz.13105. PMID: 37096339Free PMC Article
Non-Pharmacological Treatments in Lewy Body Disease: A Systematic Review.
Guidi L, Evangelisti S, Siniscalco A, Lodi R, Tonon C, Mitolo M
Dement Geriatr Cogn Disord 2023;52(1):16-31. Epub 2023 Mar 28 doi: 10.1159/000529256. PMID: 36977397
Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.
Maski K, Trotti LM, Kotagal S, Robert Auger R, Swick TJ, Rowley JA, Hashmi SD, Watson NF
J Clin Sleep Med 2021 Sep 1;17(9):1895-1945. doi: 10.5664/jcsm.9326. PMID: 34743790Free PMC Article
Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews.
Shepherd E, Salam RA, Middleton P, Makrides M, McIntyre S, Badawi N, Crowther CA
Cochrane Database Syst Rev 2017 Aug 8;8(8):CD012077. doi: 10.1002/14651858.CD012077.pub2. PMID: 28786098Free PMC Article
A systematic review of potential long-term effects of sport-related concussion.
Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL
Br J Sports Med 2017 Jun;51(12):969-977. Epub 2017 Apr 28 doi: 10.1136/bjsports-2017-097791. PMID: 28455362Free PMC Article

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