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Abnormal vertebral artery morphology

MedGen UID:
868121
•Concept ID:
C4022512
•
Anatomical Abnormality
Synonym: Abnormality of the vertebral artery
 
HPO: HP:0030321

Definition

An anomaly of the vertebral artery, the major artery of the neck that originates from the subclavian artery and merges to form the single midline basilar artery in a complex called the vertebrobasilar system. [from HPO]

Professional guidelines

PubMed

Endovascular treatment for dural arteriovenous fistulas in the petroclival region.
Hou K, Lv X, Qu L, Guo Y, Xu K, Yu J
Int J Med Sci 2020;17(18):3020-3030. Epub 2020 Oct 18 doi: 10.7150/ijms.47365. PMID: 33173422Free PMC Article
Os Odontoideum in Children: Treatment Outcomes and Neurological Risk Factors.
Helenius IJ, Bauer JM, Verhofste B, Sponseller PD, Krengel WF, Hedequist D, Cahill PJ, Larson AN, Pahys JM, Anderson JT, Martus JE, Yaszay B, Phillips JH
J Bone Joint Surg Am 2019 Oct 2;101(19):1750-1760. doi: 10.2106/JBJS.19.00314. PMID: 31577680
Endovascular treatment of cervical giant perimedullary arteriovenous fistulas.
Casasco A, Guimaraens L, Senturk C, Cotroneo E, Gigli R, Theron J
Neurosurgery 2012 Jan;70(1):141-9; discussion 149. doi: 10.1227/NEU.0b013e31822ec19e. PMID: 21796011

Recent clinical studies

Etiology

Association between Vertebral Artery Hypoplasia and Vertebral Artery Aneurysms: A Case-Control Study.
Harati A, Zeh D, Rohde S, Schultheiß R, Schmieder K, Hernesniemi J
J Neurol Surg A Cent Eur Neurosurg 2019 Sep;80(5):365-370. Epub 2019 Jul 4 doi: 10.1055/s-0038-1677453. PMID: 31272118
Vertebral artery triplication.
Gailloud P
Surg Radiol Anat 2019 Jul;41(7):841-843. Epub 2019 Jan 25 doi: 10.1007/s00276-019-02192-0. PMID: 30683994
Association between vertebral artery hypoplasia and vertebral artery aneurysms: A case-control study.
Harati A, Rohde S, Zeh D, Oni P, Schmieder K, Hernesniemi J
J Clin Neurosci 2019 Mar;61:73-77. Epub 2018 Nov 13 doi: 10.1016/j.jocn.2018.10.142. PMID: 30446362
Vertebral artery loops in surgical perspective.
Ekşi MŞ, Toktaş ZO, Yılmaz B, Demir MK, Özcan-Ekşi EE, Bayoumi AB, Yener Y, Akakın A, Konya D
Eur Spine J 2016 Dec;25(12):4171-4180. Epub 2016 Jul 7 doi: 10.1007/s00586-016-4691-1. PMID: 27388018
Aberrant Origin of Vertebral Artery and its Clinical Implications.
Yuan SM
Braz J Cardiovasc Surg 2016 Feb;31(1):52-9. doi: 10.5935/1678-9741.20150071. PMID: 27074275Free PMC Article

Diagnosis

Vertebral artery triplication.
Gailloud P
Surg Radiol Anat 2019 Jul;41(7):841-843. Epub 2019 Jan 25 doi: 10.1007/s00276-019-02192-0. PMID: 30683994
Vertebral artery loops in surgical perspective.
Ekşi MŞ, Toktaş ZO, Yılmaz B, Demir MK, Özcan-Ekşi EE, Bayoumi AB, Yener Y, Akakın A, Konya D
Eur Spine J 2016 Dec;25(12):4171-4180. Epub 2016 Jul 7 doi: 10.1007/s00586-016-4691-1. PMID: 27388018
Vertebral artery hypoplasia and vertebral artery dissection: a hospital-based cohort study.
Zhou M, Zheng H, Gong S, Guo J, Chen N, Zhou D, Yang R, Zhu C, He L
Neurology 2015 Feb 24;84(8):818-24. Epub 2015 Jan 28 doi: 10.1212/WNL.0000000000001284. PMID: 25632095
Fenestration and duplication of the vertebral artery: the anatomical and clinical points of view.
Polguj M, Podgórski M, Jędrzejewski K, Topol M, Majos A
Clin Anat 2013 Nov;26(8):933-43. Epub 2013 Mar 28 doi: 10.1002/ca.22231. PMID: 23553773
Imaging the vertebral artery.
Tay KY, U-King-Im JM, Trivedi RA, Higgins NJ, Cross JJ, Davies JR, Weissberg PL, Antoun NM, Gillard JH
Eur Radiol 2005 Jul;15(7):1329-43. Epub 2005 Jan 27 doi: 10.1007/s00330-005-2679-z. PMID: 15968519

Therapy

Association of Vertebral Artery Hypoplasia and Vertebrobasilar Cerebrovascular Accident.
Vilimas A, Gaigalaitė V, Urbonas M, Jatužis D
Medicina (Kaunas) 2022 Aug 31;58(9) doi: 10.3390/medicina58091189. PMID: 36143866Free PMC Article
Asymptomatic Extracranial Vertebral Artery Disease in Patients with Internal Carotid Artery Stenosis.
Qureshi AI, Chaudhry SA, Eckstein H, Jansen O, Ringleb PA
Neurosurgery 2017 Sep 1;81(3):531-536. doi: 10.1093/neuros/nyx092. PMID: 28379549
Vertebral artery hypoplasia and vertebral artery dissection: a hospital-based cohort study.
Zhou M, Zheng H, Gong S, Guo J, Chen N, Zhou D, Yang R, Zhu C, He L
Neurology 2015 Feb 24;84(8):818-24. Epub 2015 Jan 28 doi: 10.1212/WNL.0000000000001284. PMID: 25632095
Anatomical vertebral artery hypoplasia and insufficiency impairs dynamic blood flow regulation.
Sato K, Yoneya M, Otsuki A, Sadamoto T, Ogoh S
Clin Physiol Funct Imaging 2015 Nov;35(6):485-9. Epub 2014 Jun 30 doi: 10.1111/cpf.12179. PMID: 24980216
Dangerous extracranial-intracranial anastomoses and supply to the cranial nerves: vessels the neurointerventionalist needs to know.
Geibprasert S, Pongpech S, Armstrong D, Krings T
AJNR Am J Neuroradiol 2009 Sep;30(8):1459-68. Epub 2009 Mar 11 doi: 10.3174/ajnr.A1500. PMID: 19279274Free PMC Article

Prognosis

Vertebral artery loops in surgical perspective.
Ekşi MŞ, Toktaş ZO, Yılmaz B, Demir MK, Özcan-Ekşi EE, Bayoumi AB, Yener Y, Akakın A, Konya D
Eur Spine J 2016 Dec;25(12):4171-4180. Epub 2016 Jul 7 doi: 10.1007/s00586-016-4691-1. PMID: 27388018
Aberrant Origin of Vertebral Artery and its Clinical Implications.
Yuan SM
Braz J Cardiovasc Surg 2016 Feb;31(1):52-9. doi: 10.5935/1678-9741.20150071. PMID: 27074275Free PMC Article
Vertebral artery hypoplasia and vertebral artery dissection: a hospital-based cohort study.
Zhou M, Zheng H, Gong S, Guo J, Chen N, Zhou D, Yang R, Zhu C, He L
Neurology 2015 Feb 24;84(8):818-24. Epub 2015 Jan 28 doi: 10.1212/WNL.0000000000001284. PMID: 25632095
Fenestration and duplication of the vertebral artery: the anatomical and clinical points of view.
Polguj M, Podgórski M, Jędrzejewski K, Topol M, Majos A
Clin Anat 2013 Nov;26(8):933-43. Epub 2013 Mar 28 doi: 10.1002/ca.22231. PMID: 23553773
Vertebrobasilar dilatative arteriopathy (dolichoectasia).
Lou M, Caplan LR
Ann N Y Acad Sci 2010 Jan;1184:121-33. doi: 10.1111/j.1749-6632.2009.05114.x. PMID: 20146694

Clinical prediction guides

Clinical Characteristics of Patients with Vertebral Artery Hypoplasia.
Bakalarz M, Rożniecki JJ, Stasiołek M
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159317. PMID: 35954673Free PMC Article
Classification of vertebral artery loop formation and association with cervicogenic dizziness.
Yenigun A, Ustun ME, Tugrul S, Dogan R, Ozturan O
J Laryngol Otol 2016 Dec;130(12):1115-1119. Epub 2016 Oct 27 doi: 10.1017/S0022215116009117. PMID: 27786146
Vertebral artery loops in surgical perspective.
Ekşi MŞ, Toktaş ZO, Yılmaz B, Demir MK, Özcan-Ekşi EE, Bayoumi AB, Yener Y, Akakın A, Konya D
Eur Spine J 2016 Dec;25(12):4171-4180. Epub 2016 Jul 7 doi: 10.1007/s00586-016-4691-1. PMID: 27388018
Aberrant Origin of Vertebral Artery and its Clinical Implications.
Yuan SM
Braz J Cardiovasc Surg 2016 Feb;31(1):52-9. doi: 10.5935/1678-9741.20150071. PMID: 27074275Free PMC Article
Clinical and etiological heterogeneity in patients with tracheo-esophageal malformations and associated anomalies.
Brosens E, Ploeg M, van Bever Y, Koopmans AE, IJsselstijn H, Rottier RJ, Wijnen R, Tibboel D, de Klein A
Eur J Med Genet 2014 Aug;57(8):440-52. Epub 2014 Jun 13 doi: 10.1016/j.ejmg.2014.05.009. PMID: 24931924

Recent systematic reviews

Anatomy of vertebral artery hypoplasia and its relationship with clinical implications: a systematic review and meta-analysis of prevalence.
Valenzuela-Fuenzalida JJ, Rojas-Navia CP, Quirós-Clavero AP, Sanchis-Gimeno J, Rodriguez-Luengo M, Nova-Baeza P, Orellana-Donoso M, Becerra Farfán Á, Bruna-Mejias A, Sepúlveda-Loyola W, Iwanaga J
Surg Radiol Anat 2024 Jul;46(7):963-975. Epub 2024 May 19 doi: 10.1007/s00276-024-03377-y. PMID: 38762843
Dual origin of vertebral artery and intimal relationship with spontaneous artery dissection: a case report and systematic review.
do Nascimento DWB, da Cruz RMM, Pimenta GGD, Paschoal FM Jr, Lima Neto AM, Aviz Bastos VAP, Brito JRN, Vilhena BS, de Lima JAS, Bor-Seng-Shu E, Figueiredo EG, Texeira MJ, Paschoal EHA
Surg Radiol Anat 2021 Mar;43(3):459-465. Epub 2021 Jan 9 doi: 10.1007/s00276-020-02638-w. PMID: 33420866
Vertebral Arteriovenous Fistula: A Review Article.
Aljobeh A, Sorenson TJ, Bortolotti C, Cloft H, Lanzino G
World Neurosurg 2019 Feb;122:e1388-e1397. Epub 2018 Nov 17 doi: 10.1016/j.wneu.2018.11.063. PMID: 30458324
A systematic classification of the vertebral artery variable origin: clinical and surgical implications.
Lazaridis N, Piagkou M, Loukas M, Piperaki ET, Totlis T, Noussios G, Natsis K
Surg Radiol Anat 2018 Jul;40(7):779-797. Epub 2018 Feb 19 doi: 10.1007/s00276-018-1987-3. PMID: 29459992
A systematic review and meta-analysis of variations in branching patterns of the adult aortic arch.
Popieluszko P, Henry BM, Sanna B, Hsieh WC, Saganiak K, Pękala PA, Walocha JA, Tomaszewski KA
J Vasc Surg 2018 Jul;68(1):298-306.e10. Epub 2017 Aug 31 doi: 10.1016/j.jvs.2017.06.097. PMID: 28865978

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