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Abnormal metabolic brain imaging by MRS

MedGen UID:
868370
•Concept ID:
C4022764
•
Finding
HPO: HP:0012705

Definition

An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Professional guidelines

PubMed

Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
Altintas O, Niftaliyev E, Asil T
Neurol Res 2018 Dec;40(12):1048-1053. Epub 2018 Sep 12 doi: 10.1080/01616412.2018.1517111. PMID: 30207930
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224

Recent clinical studies

Etiology

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Higher 5-HT(1A) autoreceptor binding as an endophenotype for major depressive disorder identified in high risk offspring - A pilot study.
Milak MS, Pantazatos S, Rashid R, Zanderigo F, DeLorenzo C, Hesselgrave N, Ogden RT, Oquendo MA, Mulhern ST, Miller JM, Burke AK, Parsey RV, Mann JJ
Psychiatry Res Neuroimaging 2018 Jun 30;276:15-23. Epub 2018 Apr 13 doi: 10.1016/j.pscychresns.2018.04.002. PMID: 29702461Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
MRI-based methods to detect placental and fetal brain abnormalities in utero.
Girardi G
J Reprod Immunol 2016 Apr;114:86-91. Epub 2015 Jul 2 doi: 10.1016/j.jri.2015.05.008. PMID: 26187242
Glutamate and psychosis risk.
Egerton A, Fusar-Poli P, Stone JM
Curr Pharm Des 2012;18(4):466-78. doi: 10.2174/138161212799316244. PMID: 22239577

Diagnosis

Clinical Features of Machado-Joseph Disease.
Mendonça N, França MC Jr, Gonçalves AF, Januário C
Adv Exp Med Biol 2018;1049:255-273. doi: 10.1007/978-3-319-71779-1_13. PMID: 29427108
Respiratory chain deficiencies.
Delonlay P, Rötig A, Sarnat HB
Handb Clin Neurol 2013;113:1651-66. doi: 10.1016/B978-0-444-59565-2.00033-2. PMID: 23622386
Neuroimaging in bipolar disorder.
Strakowski SM, DelBello MP, Adler C, Cecil DM, Sax KW
Bipolar Disord 2000 Sep;2(3 Pt 1):148-64. doi: 10.1034/j.1399-5618.2000.020302.x. PMID: 11256682
Functional imaging techniques in the diagnosis of non-Alzheimer dementias.
Brooks DJ
J Neural Transm Suppl 1996;47:155-67. doi: 10.1007/978-3-7091-6892-9_10. PMID: 8841963
N-acetylaspartate and epilepsy.
Gadian DG
Magn Reson Imaging 1995;13(8):1193-5. doi: 10.1016/0730-725x(95)02032-o. PMID: 8750336

Therapy

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice.
McLoughlin HS, Gundry K, Rainwater O, Schuster KH, Wellik IG, Zalon AJ, Benneyworth MA, Eberly LE, Öz G
Ann Neurol 2023 Oct;94(4):658-671. Epub 2023 Aug 2 doi: 10.1002/ana.26713. PMID: 37243335Free PMC Article
Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
Clinical Features of Machado-Joseph Disease.
Mendonça N, França MC Jr, Gonçalves AF, Januário C
Adv Exp Med Biol 2018;1049:255-273. doi: 10.1007/978-3-319-71779-1_13. PMID: 29427108
Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study.
Gangadhar BN, Jayakumar PN, Subbakrishna DK, Janakiramaiah N, Keshavan MS
Am J Psychiatry 2004 Jul;161(7):1304-6. doi: 10.1176/appi.ajp.161.7.1304. PMID: 15229069

Prognosis

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
MRI-based methods to detect placental and fetal brain abnormalities in utero.
Girardi G
J Reprod Immunol 2016 Apr;114:86-91. Epub 2015 Jul 2 doi: 10.1016/j.jri.2015.05.008. PMID: 26187242

Clinical prediction guides

Spectrum of Clinical and Imaging Features of Children With GFAP Astrocytopathy.
Sommer S, Panzer A, Bertolini A, Cleaveland R, Jain V, Kapanci T, Derichs U, Geis T, Neu A, Löhr-Nilles C, Aeschimann-Huhn R, Flotats-Bastardas M, Deiva K, Armangue T, Olivé-Cirera G, Kannoth S, Koy A, Meirson H, Fattal-Valevski A, Ganelin-Cohen E, Losch H, Horne A, Wickström R, Dargvainiene J, Leypoldt F, Rostasy K
Neurol Neuroimmunol Neuroinflamm 2025 Jan;12(1):e200327. Epub 2024 Nov 20 doi: 10.1212/NXI.0000000000200327. PMID: 39566024Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation.
Salavati B, Rajji TK, Price R, Sun Y, Graff-Guerrero A, Daskalakis ZJ
Schizophr Bull 2015 Jan;41(1):44-56. Epub 2014 Sep 22 doi: 10.1093/schbul/sbu132. PMID: 25249654Free PMC Article
Neuroimaging in bipolar disorder.
Strakowski SM, DelBello MP, Adler C, Cecil DM, Sax KW
Bipolar Disord 2000 Sep;2(3 Pt 1):148-64. doi: 10.1034/j.1399-5618.2000.020302.x. PMID: 11256682

Recent systematic reviews

Brain mechanisms underlying catatonia: A systematic review.
Cattarinussi G, Gugliotta AA, Hirjak D, Wolf RC, Sambataro F
Schizophr Res 2024 Jan;263:194-207. Epub 2022 Nov 18 doi: 10.1016/j.schres.2022.11.002. PMID: 36404217
Aggression in borderline personality disorder: A systematic review of neuroimaging studies.
Chu J, Zheng K, Yi J
Prog Neuropsychopharmacol Biol Psychiatry 2022 Mar 8;113:110472. Epub 2021 Nov 4 doi: 10.1016/j.pnpbp.2021.110472. PMID: 34742774
Migraine and magnetic resonance spectroscopy: a systematic review.
Younis S, Hougaard A, Vestergaard MB, Larsson HBW, Ashina M
Curr Opin Neurol 2017 Jun;30(3):246-262. doi: 10.1097/WCO.0000000000000436. PMID: 28240609
Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation.
Salavati B, Rajji TK, Price R, Sun Y, Graff-Guerrero A, Daskalakis ZJ
Schizophr Bull 2015 Jan;41(1):44-56. Epub 2014 Sep 22 doi: 10.1093/schbul/sbu132. PMID: 25249654Free PMC Article
A systematic review of Magnetic Resonance Imaging and Spectroscopy in brain injury after drowning.
Nucci-da-Silva MP, Amaro E Jr
Brain Inj 2009 Aug;23(9):707-14. doi: 10.1080/02699050903123351. PMID: 19636995

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