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Abnormal T3/T4 ratio

MedGen UID:
868453
•Concept ID:
C4022847
•
Anatomical Abnormality
HPO: HP:0012558

Definition

A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal T3/T4 ratio

Professional guidelines

PubMed

Iodized oil treatment for endemic goiter does not induce the surge of positive serum concentrations of anti-thyroglobulin or anti-microsomal autoantibodies.
Knobel M, Medeiros-Neto G
J Endocrinol Invest 1986 Aug;9(4):321-4. doi: 10.1007/BF03346935. PMID: 3023472

Recent clinical studies

Etiology

Association of T3/T4 ratio with inflammatory indicators and all-cause mortality in stroke survivors.
Zhang S, Su Z, Wen X
Front Endocrinol (Lausanne) 2024;15:1509501. Epub 2025 Jan 8 doi: 10.3389/fendo.2024.1509501. PMID: 39845883Free PMC Article
Artificial Intelligence-Based Prediction of Recurrence after Curative Resection for Colorectal Cancer from Digital Pathological Images.
Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T
Ann Surg Oncol 2023 Jun;30(6):3506-3514. Epub 2022 Dec 13 doi: 10.1245/s10434-022-12926-x. PMID: 36512260
Stability of nasal symmetry following primary cleft lip and nasal repair: five years of follow-up.
Alkebsi K, Sakran KA, Abdo Y, Shi B, Li C
Int J Oral Maxillofac Surg 2023 Apr;52(4):451-459. Epub 2022 Aug 13 doi: 10.1016/j.ijom.2022.07.011. PMID: 35973881
Quantification of serum thyroid hormones using tandem mass spectrometry in patients with Down syndrome.
Iwano R, Toki M, Hanakawa J, Asakura Y, Adachi M, Tanaka Y, Muroya K
Biomed Chromatogr 2022 Jan;36(1):e5249. Epub 2021 Oct 19 doi: 10.1002/bmc.5249. PMID: 34569083
Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.
Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R
Biol Trace Elem Res 1996 Jan;51(1):31-41. doi: 10.1007/BF02790145. PMID: 8834378

Diagnosis

Quantification of serum thyroid hormones using tandem mass spectrometry in patients with Down syndrome.
Iwano R, Toki M, Hanakawa J, Asakura Y, Adachi M, Tanaka Y, Muroya K
Biomed Chromatogr 2022 Jan;36(1):e5249. Epub 2021 Oct 19 doi: 10.1002/bmc.5249. PMID: 34569083
Relative Morphokinetics Assessed by Time-Lapse Imaging Are Altered in Embryos From Patients With Endometriosis.
Freis A, Dietrich JE, Binder M, Holschbach V, Strowitzki T, Germeyer A
Reprod Sci 2018 Aug;25(8):1279-1285. Epub 2017 Nov 15 doi: 10.1177/1933719117741373. PMID: 29141509
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Wit JM, Oostdijk W, Losekoot M, van Duyvenvoorde HA, Ruivenkamp CA, Kant SG
Eur J Endocrinol 2016 Apr;174(4):R145-73. Epub 2015 Nov 17 doi: 10.1530/EJE-15-0937. PMID: 26578640
Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients.
Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, Vigneri R
PLoS One 2011;6(8):e22552. Epub 2011 Aug 1 doi: 10.1371/journal.pone.0022552. PMID: 21829633Free PMC Article
Thyroid function in molar pregnancy.
Nagataki S, Mizuno M, Sakamoto S, Irie M, Shizume K
J Clin Endocrinol Metab 1977 Feb;44(2):254-63. doi: 10.1210/jcem-44-2-254. PMID: 402378

Therapy

Artificial Intelligence-Based Prediction of Recurrence after Curative Resection for Colorectal Cancer from Digital Pathological Images.
Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T
Ann Surg Oncol 2023 Jun;30(6):3506-3514. Epub 2022 Dec 13 doi: 10.1245/s10434-022-12926-x. PMID: 36512260
Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
Ettleson MD, Bianco AC
J Clin Endocrinol Metab 2020 Sep 1;105(9):e3090-104. doi: 10.1210/clinem/dgaa430. PMID: 32614450Free PMC Article
The first postesophagectomy chest X-ray predicts respiratory failure and the need for tracheostomy.
Gabriel E, Shah R, Attwood K, Kukar M, Hochwald S
J Surg Res 2018 Apr;224:89-96. Epub 2017 Dec 22 doi: 10.1016/j.jss.2017.11.057. PMID: 29506857
Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients.
Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, Vigneri R
PLoS One 2011;6(8):e22552. Epub 2011 Aug 1 doi: 10.1371/journal.pone.0022552. PMID: 21829633Free PMC Article
Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.
Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R
Biol Trace Elem Res 1996 Jan;51(1):31-41. doi: 10.1007/BF02790145. PMID: 8834378

Prognosis

Artificial Intelligence-Based Prediction of Recurrence after Curative Resection for Colorectal Cancer from Digital Pathological Images.
Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T
Ann Surg Oncol 2023 Jun;30(6):3506-3514. Epub 2022 Dec 13 doi: 10.1245/s10434-022-12926-x. PMID: 36512260
Stability of nasal symmetry following primary cleft lip and nasal repair: five years of follow-up.
Alkebsi K, Sakran KA, Abdo Y, Shi B, Li C
Int J Oral Maxillofac Surg 2023 Apr;52(4):451-459. Epub 2022 Aug 13 doi: 10.1016/j.ijom.2022.07.011. PMID: 35973881
Clinical Prognostic Significance of HOXC9 Expression in Patients with Colorectal Cancer.
Hu M, Ou-Yang W, Jing D, Chen R
Clin Lab 2019 Aug 1;65(8) doi: 10.7754/Clin.Lab.2019.190122. PMID: 31414766
The first postesophagectomy chest X-ray predicts respiratory failure and the need for tracheostomy.
Gabriel E, Shah R, Attwood K, Kukar M, Hochwald S
J Surg Res 2018 Apr;224:89-96. Epub 2017 Dec 22 doi: 10.1016/j.jss.2017.11.057. PMID: 29506857
Relative Morphokinetics Assessed by Time-Lapse Imaging Are Altered in Embryos From Patients With Endometriosis.
Freis A, Dietrich JE, Binder M, Holschbach V, Strowitzki T, Germeyer A
Reprod Sci 2018 Aug;25(8):1279-1285. Epub 2017 Nov 15 doi: 10.1177/1933719117741373. PMID: 29141509

Clinical prediction guides

Artificial Intelligence-Based Prediction of Recurrence after Curative Resection for Colorectal Cancer from Digital Pathological Images.
Nakanishi R, Morooka K, Omori K, Toyota S, Tanaka Y, Hasuda H, Koga N, Nonaka K, Hu Q, Nakaji Y, Nakanoko T, Ando K, Ota M, Kimura Y, Oki E, Oda Y, Yoshizumi T
Ann Surg Oncol 2023 Jun;30(6):3506-3514. Epub 2022 Dec 13 doi: 10.1245/s10434-022-12926-x. PMID: 36512260
Thyroid disease in patients with McCune-Albright syndrome.
Congedo V, Celi FS
Pediatr Endocrinol Rev 2007 Aug;4 Suppl 4:429-33. PMID: 17982391
Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.
Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R
Biol Trace Elem Res 1996 Jan;51(1):31-41. doi: 10.1007/BF02790145. PMID: 8834378
Abnormalities of T cell maturation and regulation in human beings with immunodeficiency disorders.
Reinherz EL, Cooper MD, Schlossman SF, Rosen FS
J Clin Invest 1981 Sep;68(3):699-705. doi: 10.1172/jci110305. PMID: 6974177Free PMC Article
Thyroid function in molar pregnancy.
Nagataki S, Mizuno M, Sakamoto S, Irie M, Shizume K
J Clin Endocrinol Metab 1977 Feb;44(2):254-63. doi: 10.1210/jcem-44-2-254. PMID: 402378

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