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Abnormal respiratory epithelium morphology

MedGen UID:
868592
Concept ID:
C4022991
Anatomical Abnormality
HPO: HP:0012253

Definition

Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. [from HPO]

Professional guidelines

PubMed

Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Jin KF, Lou ZC, Lou ZH
J Laryngol Otol 2019 Jun;133(6):538-541. Epub 2019 Apr 22 doi: 10.1017/S0022215119000793. PMID: 31006394
Cingi C, Demirbas D, Ural A
Recent Pat Inflamm Allergy Drug Discov 2011 Sep;5(3):241-52. doi: 10.2174/187221311797264900. PMID: 21834752

Recent clinical studies

Etiology

Selman M, Pardo A
Cell Signal 2020 Feb;66:109482. Epub 2019 Nov 21 doi: 10.1016/j.cellsig.2019.109482. PMID: 31760172
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Carsin A, Mazenq J, Ilstad A, Dubus JC, Chanez P, Gras D
Eur Respir Rev 2016 Jun;25(140):158-69. doi: 10.1183/16000617.0101-2015. PMID: 27246593Free PMC Article
Fete T
Am J Med Genet A 2014 Oct;164A(10):2478-81. Epub 2014 May 19 doi: 10.1002/ajmg.a.36600. PMID: 24842607
Katayama Y, Kusagawa H, Komada T, Shomura S, Tenpaku H
Gen Thorac Cardiovasc Surg 2011 Nov;59(11):767-70. Epub 2011 Nov 15 doi: 10.1007/s11748-010-0763-z. PMID: 22083698

Diagnosis

Legendre M, Zaragosi LE, Mitchison HM
Semin Cell Dev Biol 2021 Feb;110:19-33. Epub 2020 Dec 2 doi: 10.1016/j.semcdb.2020.11.007. PMID: 33279404
Lal CV, Bhandari V, Ambalavanan N
Semin Perinatol 2018 Nov;42(7):425-431. Epub 2018 Oct 2 doi: 10.1053/j.semperi.2018.09.004. PMID: 30487069Free PMC Article
Jankowski R, Nguyen DT, Gallet P, Rumeau C
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec;135(6):437-441. Epub 2018 Jun 20 doi: 10.1016/j.anorl.2018.05.008. PMID: 29934261
Carachi R, Azmy A
Pediatr Surg Int 2002 Sep;18(5-6):371-4. Epub 2002 May 9 doi: 10.1007/s00383-002-0835-y. PMID: 12415358
Bush A
Acta Otorhinolaryngol Belg 2000;54(3):317-24. PMID: 11082768

Therapy

Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Looi K, Evans DJ, Garratt LW, Ang S, Hillas JK, Kicic A, Simpson SJ
Paediatr Respir Rev 2019 Aug;31:82-88. Epub 2018 Dec 1 doi: 10.1016/j.prrv.2018.11.003. PMID: 31103368
Jankowski R, Nguyen DT, Gallet P, Rumeau C
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec;135(6):437-441. Epub 2018 Jun 20 doi: 10.1016/j.anorl.2018.05.008. PMID: 29934261
Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118
Harber P, Saechao K, Boomus C
Toxicol Rev 2006;25(4):261-72. doi: 10.2165/00139709-200625040-00006. PMID: 17288497

Prognosis

Planté-Bordeneuve T, Pilette C, Froidure A
Front Immunol 2021;12:631235. Epub 2021 May 19 doi: 10.3389/fimmu.2021.631235. PMID: 34093523Free PMC Article
Legendre M, Zaragosi LE, Mitchison HM
Semin Cell Dev Biol 2021 Feb;110:19-33. Epub 2020 Dec 2 doi: 10.1016/j.semcdb.2020.11.007. PMID: 33279404
Lal CV, Bhandari V, Ambalavanan N
Semin Perinatol 2018 Nov;42(7):425-431. Epub 2018 Oct 2 doi: 10.1053/j.semperi.2018.09.004. PMID: 30487069Free PMC Article
Borie R, Wislez M, Antoine M, Copie-Bergman C, Thieblemont C, Cadranel J
Eur Respir J 2016 Apr;47(4):1244-60. Epub 2016 Jan 21 doi: 10.1183/13993003.01701-2015. PMID: 26797028
Gonfiotti A, Jaus MO, Barale D, Baiguera S, Comin C, Lavorini F, Fontana G, Sibila O, Rombolà G, Jungebluth P, Macchiarini P
Lancet 2014 Jan 18;383(9913):238-44. Epub 2013 Oct 23 doi: 10.1016/S0140-6736(13)62033-4. PMID: 24161821

Clinical prediction guides

Zhang RL, Pan CX, Tang CL, Cen LJ, Zhang XX, Huang Y, Lin ZH, Li HM, Zhang XF, Wang L, Guan WJ, Wang Y
Chest 2023 May;163(5):1038-1050. Epub 2022 Nov 24 doi: 10.1016/j.chest.2022.11.022. PMID: 36435264
Peña-Melián Á, Cabello-de la Rosa JP, Gallardo-Alcañiz MJ, Vaamonde-Gamo J, Relea-Calatayud F, González-López L, Villanueva-Anguita P, Flores-Cuadrado A, Saiz-Sánchez D, Martínez-Marcos A
Anat Rec (Hoboken) 2019 Mar;302(3):394-404. Epub 2018 May 17 doi: 10.1002/ar.23826. PMID: 29663690
Lal CV, Bhandari V, Ambalavanan N
Semin Perinatol 2018 Nov;42(7):425-431. Epub 2018 Oct 2 doi: 10.1053/j.semperi.2018.09.004. PMID: 30487069Free PMC Article
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Sumi Y, Hamid Q
Allergol Int 2007 Dec;56(4):341-8. Epub 2007 Nov 1 doi: 10.2332/allergolint.R-07-153. PMID: 17965577

Recent systematic reviews

Adil EA, Kawai K, Dombrowski N, Irace AL, Cunningham MJ
Laryngoscope 2017 Jan;127(1):6-13. Epub 2016 Jun 16 doi: 10.1002/lary.26070. PMID: 27312809
Boyce J, Eccles R
Clin Otolaryngol 2006 Feb;31(1):15-9. doi: 10.1111/j.1749-4486.2006.01125.x. PMID: 16441795

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