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Acute disseminated intravascular coagulation

MedGen UID:
868744
•Concept ID:
C4023149
•
Disease or Syndrome
HPO: HP:0011880

Definition

An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute disseminated intravascular coagulation

Professional guidelines

PubMed

Practice Bulletin No. 183: Postpartum Hemorrhage.
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571
UK malaria treatment guidelines 2016.
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article
Diagnosis and management of neonatal purpura fulminans.
Price VE, Ledingham DL, Krümpel A, Chan AK
Semin Fetal Neonatal Med 2011 Dec;16(6):318-22. Epub 2011 Aug 11 doi: 10.1016/j.siny.2011.07.009. PMID: 21839696

Recent clinical studies

Etiology

Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A
Curr Opin Hematol 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. PMID: 27380556
Coagulopathy of Acute Sepsis.
Semeraro N, Ammollo CT, Semeraro F, Colucci M
Semin Thromb Hemost 2015 Sep;41(6):650-8. Epub 2015 Aug 25 doi: 10.1055/s-0035-1556730. PMID: 26305237
Heparin-induced thrombocytopenia in critically ill patients.
Warkentin TE
Semin Thromb Hemost 2015 Feb;41(1):49-60. Epub 2015 Jan 15 doi: 10.1055/s-0034-1398381. PMID: 25590528
Coagulation abnormalities in sepsis.
Tsao CM, Ho ST, Wu CC
Acta Anaesthesiol Taiwan 2015 Mar;53(1):16-22. Epub 2014 Dec 26 doi: 10.1016/j.aat.2014.11.002. PMID: 25544351
Sepsis, thrombosis and organ dysfunction.
Semeraro N, Ammollo CT, Semeraro F, Colucci M
Thromb Res 2012 Mar;129(3):290-5. Epub 2011 Nov 5 doi: 10.1016/j.thromres.2011.10.013. PMID: 22061311

Diagnosis

Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion.
Waddle M, Irvin M, Gupta E, Gibbs M, Kakar TS, Gannon NA, Arthurs JR, Fischer DL, Ailawadhi S
Chemotherapy 2017;62(5):295-300. Epub 2017 May 16 doi: 10.1159/000471844. PMID: 28505615
Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A
Curr Opin Hematol 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. PMID: 27380556
Coagulopathy of Acute Sepsis.
Semeraro N, Ammollo CT, Semeraro F, Colucci M
Semin Thromb Hemost 2015 Sep;41(6):650-8. Epub 2015 Aug 25 doi: 10.1055/s-0035-1556730. PMID: 26305237
Coagulation abnormalities in sepsis.
Tsao CM, Ho ST, Wu CC
Acta Anaesthesiol Taiwan 2015 Mar;53(1):16-22. Epub 2014 Dec 26 doi: 10.1016/j.aat.2014.11.002. PMID: 25544351
Diagnosis and management of neonatal purpura fulminans.
Price VE, Ledingham DL, Krümpel A, Chan AK
Semin Fetal Neonatal Med 2011 Dec;16(6):318-22. Epub 2011 Aug 11 doi: 10.1016/j.siny.2011.07.009. PMID: 21839696

Therapy

Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion.
Waddle M, Irvin M, Gupta E, Gibbs M, Kakar TS, Gannon NA, Arthurs JR, Fischer DL, Ailawadhi S
Chemotherapy 2017;62(5):295-300. Epub 2017 May 16 doi: 10.1159/000471844. PMID: 28505615
Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A
Curr Opin Hematol 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. PMID: 27380556
Heparin-induced thrombocytopenia in critically ill patients.
Warkentin TE
Semin Thromb Hemost 2015 Feb;41(1):49-60. Epub 2015 Jan 15 doi: 10.1055/s-0034-1398381. PMID: 25590528
Coagulation abnormalities in sepsis.
Tsao CM, Ho ST, Wu CC
Acta Anaesthesiol Taiwan 2015 Mar;53(1):16-22. Epub 2014 Dec 26 doi: 10.1016/j.aat.2014.11.002. PMID: 25544351
Hematologic manifestations of malignancy.
Johnson RA, Roodman GD
Dis Mon 1989 Nov;35(11):721-68. doi: 10.1016/0011-5029(89)90011-4. PMID: 2680358

Prognosis

Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion.
Waddle M, Irvin M, Gupta E, Gibbs M, Kakar TS, Gannon NA, Arthurs JR, Fischer DL, Ailawadhi S
Chemotherapy 2017;62(5):295-300. Epub 2017 May 16 doi: 10.1159/000471844. PMID: 28505615
Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009).
Rattray DD, O'Connell CM, Baskett TF
J Obstet Gynaecol Can 2012 Apr;34(4):341-347. doi: 10.1016/S1701-2163(16)35214-8. PMID: 22472333
The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.
Hook KM, Abrams CS
Clin Transl Sci 2012 Feb;5(1):85-92. Epub 2011 Dec 7 doi: 10.1111/j.1752-8062.2011.00351.x. PMID: 22376264Free PMC Article
Acute disseminated intravascular coagulation syndrome in cancer patients.
Pasquini E, Gianni L, Aitini E, Nicolini M, Fattori PP, Cavazzini G, Desiderio F, Monti F, Forghieri ME, Ravaioli A
Oncology 1995 Nov-Dec;52(6):505-8. doi: 10.1159/000227520. PMID: 7478440
Improved or fatal acute disseminated intravascular coagulation in systemic lupus erythematosus.
Shimamoto Y, Ohta A, Sano M, Suga K, Yamaguchi M
Am J Hematol 1993 Feb;42(2):191-5. doi: 10.1002/ajh.2830420210. PMID: 8438879

Clinical prediction guides

Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated Coagulopathy.
Wiedermann CJ
Int J Mol Sci 2022 Oct 18;23(20) doi: 10.3390/ijms232012474. PMID: 36293332Free PMC Article
Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives.
Sengupta T, Majumder R, Majumder S
Mol Cell Biochem 2021 Jun;476(6):2421-2427. Epub 2021 Feb 18 doi: 10.1007/s11010-021-04093-6. PMID: 33604809Free PMC Article
Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009).
Rattray DD, O'Connell CM, Baskett TF
J Obstet Gynaecol Can 2012 Apr;34(4):341-347. doi: 10.1016/S1701-2163(16)35214-8. PMID: 22472333
The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.
Hook KM, Abrams CS
Clin Transl Sci 2012 Feb;5(1):85-92. Epub 2011 Dec 7 doi: 10.1111/j.1752-8062.2011.00351.x. PMID: 22376264Free PMC Article
Acute disseminated intravascular coagulation syndrome in cancer patients.
Pasquini E, Gianni L, Aitini E, Nicolini M, Fattori PP, Cavazzini G, Desiderio F, Monti F, Forghieri ME, Ravaioli A
Oncology 1995 Nov-Dec;52(6):505-8. doi: 10.1159/000227520. PMID: 7478440

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