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Abnormal parathyroid morphology

MedGen UID:
868794
•Concept ID:
C4023199
•
Anatomical Abnormality
Synonym: Abnormality of the parathyroid morphology
 
HPO: HP:0011766

Definition

A structural abnormality of the parathyroid gland. [from HPO]

Professional guidelines

PubMed

Pathogenesis and Management of Vascular Calcification in Patients with End-Stage Renal Disease.
Ogawa T, Nitta K
Contrib Nephrol 2018;196:71-77. Epub 2018 Jul 24 doi: 10.1159/000485702. PMID: 30041207
Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy.
Martin KJ, Olgaard K, Coburn JW, Coen GM, Fukagawa M, Langman C, Malluche HH, McCarthy JT, Massry SG, Mehls O, Salusky IB, Silver JM, Smogorzewski MT, Slatopolsky EM, McCann L; Bone Turnover Work Group
Am J Kidney Dis 2004 Mar;43(3):558-65. doi: 10.1053/j.ajkd.2003.12.003. PMID: 14981615
The primary immunodeficiency diseases: classification, pathogenesis and treatment.
Gatti RA, Seligmann M
Turk J Pediatr 1973 Oct;15(4):195-215. PMID: 4600502

Recent clinical studies

Etiology

Skeletal Manifestations of Hypoparathyroidism.
Rubin MR
Bone 2019 Mar;120:548-555. Epub 2018 Nov 19 doi: 10.1016/j.bone.2018.11.012. PMID: 30465918
Skeletal Manifestations of Hypoparathyroidism.
Rubin MR
Endocrinol Metab Clin North Am 2018 Dec;47(4):825-837. doi: 10.1016/j.ecl.2018.07.008. PMID: 30390816
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease.
Felsenfeld AJ, Levine BS, Rodriguez M
Semin Dial 2015 Nov-Dec;28(6):564-77. Epub 2015 Aug 25 doi: 10.1111/sdi.12411. PMID: 26303319
Sudden death in babies: epidemiology.
Froggatt P, Lynas MA, Marshall TK
Am J Cardiol 1968 Oct;22(4):457-68. doi: 10.1016/0002-9149(68)90152-5. PMID: 4880100

Diagnosis

Overview of the 2022 WHO Classification of Parathyroid Tumors.
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Skin manifestations of endocrine and neuroendocrine tumors.
Leventhal JS, Braverman IM
Semin Oncol 2016 Jun;43(3):335-40. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.022. PMID: 27178685
Parathyroid imaging.
Johnson NA, Carty SE, Tublin ME
Radiol Clin North Am 2011 May;49(3):489-509, vi. doi: 10.1016/j.rcl.2011.02.009. PMID: 21569907
Parathyroid imaging.
Fakhran S, Branstetter BF 4th, Pryma DA
Neuroimaging Clin N Am 2008 Aug;18(3):537-49, ix. doi: 10.1016/j.nic.2008.03.006. PMID: 18656034

Therapy

Skeletal Manifestations of Hypoparathyroidism.
Rubin MR
Bone 2019 Mar;120:548-555. Epub 2018 Nov 19 doi: 10.1016/j.bone.2018.11.012. PMID: 30465918
Skeletal Manifestations of Hypoparathyroidism.
Rubin MR
Endocrinol Metab Clin North Am 2018 Dec;47(4):825-837. doi: 10.1016/j.ecl.2018.07.008. PMID: 30390816
A garden of parathyroid adenomas.
Sahli ZT, Karipineni F, Zeiger MA
BMJ Case Rep 2017 Aug 3;2017 doi: 10.1136/bcr-2017-221130. PMID: 28775107Free PMC Article
DiGeorge syndrome and related syndromes associated with 22q11.2 deletions. A review.
Demczuk S, Aurias A
Ann Genet 1995;38(2):59-76. PMID: 7486827
Immune deficiency diseases.
Hitzig WH
J Clin Pathol Suppl (Assoc Clin Pathol) 1975;6:83-91. doi: 10.1136/jcp.s1-6.1.83. PMID: 802876Free PMC Article

Prognosis

Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Report of two novel mutations in PTHLH associated with brachydactyly type E and literature review.
Thomas-Teinturier C, Pereda A, Garin I, Diez-Lopez I, Linglart A, Silve C, de Nanclares GP
Am J Med Genet A 2016 Mar;170(3):734-42. Epub 2015 Dec 6 doi: 10.1002/ajmg.a.37490. PMID: 26640227
Congenital anomalies of the branchial apparatus: embryology and pathologic anatomy.
Benson MT, Dalen K, Mancuso AA, Kerr HH, Cacciarelli AA, Mafee MF
Radiographics 1992 Sep;12(5):943-60. doi: 10.1148/radiographics.12.5.1529135. PMID: 1529135
Sudden death in babies: epidemiology.
Froggatt P, Lynas MA, Marshall TK
Am J Cardiol 1968 Oct;22(4):457-68. doi: 10.1016/0002-9149(68)90152-5. PMID: 4880100

Clinical prediction guides

Expansive renal osteitis fibrosa: a case report.
Andrade GS, de Souza Carvalho ACG, Magalhães TG, Cetira Filho EL, Cavalcante RB, Nogueira RLM
Oral Maxillofac Surg 2018 Sep;22(3):323-327. Epub 2018 May 4 doi: 10.1007/s10006-018-0697-7. PMID: 29725779
Report of two novel mutations in PTHLH associated with brachydactyly type E and literature review.
Thomas-Teinturier C, Pereda A, Garin I, Diez-Lopez I, Linglart A, Silve C, de Nanclares GP
Am J Med Genet A 2016 Mar;170(3):734-42. Epub 2015 Dec 6 doi: 10.1002/ajmg.a.37490. PMID: 26640227
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Congenital anomalies of the branchial apparatus: embryology and pathologic anatomy.
Benson MT, Dalen K, Mancuso AA, Kerr HH, Cacciarelli AA, Mafee MF
Radiographics 1992 Sep;12(5):943-60. doi: 10.1148/radiographics.12.5.1529135. PMID: 1529135
Calcium and hypertension.
Sowers JR, Zemel MB, Standley PR, Zemel PC
J Lab Clin Med 1989 Oct;114(4):338-48. PMID: 2677196

Recent systematic reviews

Intrathyroidal Parathyroid Carcinoma: Case Report and Literature Review.
Daniel H, Pillutla P, Schwartz C, Nguyen T
Ear Nose Throat J 2025 Jan;104(1):30-35. Epub 2022 Apr 9 doi: 10.1177/01455613221093729. PMID: 35403461
Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports.
Ma H, Brooks JA, Iwata AJ, Li P, Zhong Q, Fang J, Randolph GW
Laryngoscope 2021 Sep;131(9):E2609-E2617. Epub 2021 Jun 29 doi: 10.1002/lary.29678. PMID: 34184770Free PMC Article
Mineral bone disorders in chronic kidney disease.
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Are neuroendocrine tumours a feature of tuberous sclerosis? A systematic review.
Dworakowska D, Grossman AB
Endocr Relat Cancer 2009 Mar;16(1):45-58. Epub 2008 Oct 31 doi: 10.1677/ERC-08-0142. PMID: 18978035

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