U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal corneal epithelium morphology

MedGen UID:
868915
•Concept ID:
C4023326
•
Anatomical Abnormality
Synonym: Abnormality of corneal epithelium
 
HPO: HP:0011495

Definition

Abnormality of the corneal epithelium, that is of the epithelial tissue that covers the front of the cornea. [from HPO]

Professional guidelines

PubMed

The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye.
Lima Cunha D, Arno G, Corton M, Moosajee M
Genes (Basel) 2019 Dec 17;10(12) doi: 10.3390/genes10121050. PMID: 31861090Free PMC Article
Clinical results and influential factors of modified large-diameter lamellar keratoplasty in the treatment of total limbal stem cell deficiency.
Qi X, Xie L, Cheng J, Zhao J
Cornea 2013 May;32(5):555-60. doi: 10.1097/ICO.0b013e318255394e. PMID: 22580444
Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and management.
Dua HS, Saini JS, Azuara-Blanco A, Gupta P
Indian J Ophthalmol 2000 Jun;48(2):83-92. PMID: 11116520

Recent clinical studies

Etiology

Ocular Involvement in Hereditary Amyloidosis.
Minnella AM, Rissotto R, Antoniazzi E, Di Girolamo M, Luigetti M, Maceroni M, Bacherini D, Falsini B, Rizzo S, Obici L
Genes (Basel) 2021 Jun 22;12(7) doi: 10.3390/genes12070955. PMID: 34206500Free PMC Article
Short-Term Results Analysis in the Allogenic Transplantation of Limbal Stem Cells Expanded on Amniotic Membrane in Patients with Bilateral Limbal Stem Cell Deficiency.
Serna-Ojeda JC, García-Mejía M, Graue-Hernández EO, Navas A, Garfias Y
J Ocul Pharmacol Ther 2020 May;36(4):238-246. Epub 2020 Feb 20 doi: 10.1089/jop.2019.0147. PMID: 32077779
Corneal dystrophies.
Klintworth GK
Orphanet J Rare Dis 2009 Feb 23;4:7. doi: 10.1186/1750-1172-4-7. PMID: 19236704Free PMC Article
Baseline donor characteristics in the Cornea Donor Study.
Sugar A, Gal RL, Beck rW, Ruedy KJ, Blanton CL, Feder RS, Hardten DR, Holland EJ, Lass JH, Mannis MJ, O'Keefe MB; Cornea Donor Study Group
Cornea 2005 May;24(4):389-96. doi: 10.1097/01.ico.0000151503.26695.f0. PMID: 15829793
Exfoliation syndrome.
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Diagnosis

Ocular Involvement in Hereditary Amyloidosis.
Minnella AM, Rissotto R, Antoniazzi E, Di Girolamo M, Luigetti M, Maceroni M, Bacherini D, Falsini B, Rizzo S, Obici L
Genes (Basel) 2021 Jun 22;12(7) doi: 10.3390/genes12070955. PMID: 34206500Free PMC Article
Solitary Nonvascularized Corneal Epithelial Dysplasia.
Jeon HS, Shin E, Hyon JY
Ophthalmology 2017 Aug;124(8):1185. doi: 10.1016/j.ophtha.2017.01.035. PMID: 28734333
Diagnostic and Therapeutic Challenges.
Elshatory YM, Carver A, Shah VA, Aleman TS
Retina 2016 Apr;36(4):840-5. doi: 10.1097/IAE.0000000000000704. PMID: 26225484
Corneal dystrophies.
Klintworth GK
Orphanet J Rare Dis 2009 Feb 23;4:7. doi: 10.1186/1750-1172-4-7. PMID: 19236704Free PMC Article
Exfoliation syndrome.
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Therapy

Short-Term Results Analysis in the Allogenic Transplantation of Limbal Stem Cells Expanded on Amniotic Membrane in Patients with Bilateral Limbal Stem Cell Deficiency.
Serna-Ojeda JC, García-Mejía M, Graue-Hernández EO, Navas A, Garfias Y
J Ocul Pharmacol Ther 2020 May;36(4):238-246. Epub 2020 Feb 20 doi: 10.1089/jop.2019.0147. PMID: 32077779
Multifocal Vortex Keratopathy.
Tan N, Thaung C, Tuft S
Cornea 2020 Aug;39(8):1052-1054. doi: 10.1097/ICO.0000000000002285. PMID: 32073455
Unusual Photophobia in a Child.
Osigian Probst CJ, Chang TC, Cavuoto KM
JAMA Ophthalmol 2016 Oct 1;134(10):1195-1196. doi: 10.1001/jamaophthalmol.2016.1825. PMID: 27490065
Lid wiper epitheliopathy.
Efron N, Brennan NA, Morgan PB, Wilson T
Prog Retin Eye Res 2016 Jul;53:140-174. Epub 2016 Apr 14 doi: 10.1016/j.preteyeres.2016.04.004. PMID: 27094372
Baseline donor characteristics in the Cornea Donor Study.
Sugar A, Gal RL, Beck rW, Ruedy KJ, Blanton CL, Feder RS, Hardten DR, Holland EJ, Lass JH, Mannis MJ, O'Keefe MB; Cornea Donor Study Group
Cornea 2005 May;24(4):389-96. doi: 10.1097/01.ico.0000151503.26695.f0. PMID: 15829793

Prognosis

Short-Term Results Analysis in the Allogenic Transplantation of Limbal Stem Cells Expanded on Amniotic Membrane in Patients with Bilateral Limbal Stem Cell Deficiency.
Serna-Ojeda JC, García-Mejía M, Graue-Hernández EO, Navas A, Garfias Y
J Ocul Pharmacol Ther 2020 May;36(4):238-246. Epub 2020 Feb 20 doi: 10.1089/jop.2019.0147. PMID: 32077779
Multifocal Vortex Keratopathy.
Tan N, Thaung C, Tuft S
Cornea 2020 Aug;39(8):1052-1054. doi: 10.1097/ICO.0000000000002285. PMID: 32073455
Ocular surface reconstruction by cultivated epithelial sheet transplantation.
Satake Y, Yamaguchi T, Hirayama M, Higa K, Shimazaki-Den S, Dogru M, Kawakita T, Kawashima M, Shimmura S, Tsubota K, Shimazaki J
Cornea 2014 Nov;33 Suppl 11:S42-6. doi: 10.1097/ICO.0000000000000242. PMID: 25289723
Corneal dystrophies.
Klintworth GK
Orphanet J Rare Dis 2009 Feb 23;4:7. doi: 10.1186/1750-1172-4-7. PMID: 19236704Free PMC Article
Exfoliation syndrome.
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Clinical prediction guides

Association of torpedo maculopathy and keratoconus in a young patient: A multimodal imaging study.
Cozzupoli GM, Fasciani R, Fedeli R, Rizzo S
Eur J Ophthalmol 2024 Jan;34(1):52-58. Epub 2023 Oct 16 doi: 10.1177/11206721231207663. PMID: 37844612
Lid wiper epitheliopathy.
Efron N, Brennan NA, Morgan PB, Wilson T
Prog Retin Eye Res 2016 Jul;53:140-174. Epub 2016 Apr 14 doi: 10.1016/j.preteyeres.2016.04.004. PMID: 27094372
Baseline donor characteristics in the Cornea Donor Study.
Sugar A, Gal RL, Beck rW, Ruedy KJ, Blanton CL, Feder RS, Hardten DR, Holland EJ, Lass JH, Mannis MJ, O'Keefe MB; Cornea Donor Study Group
Cornea 2005 May;24(4):389-96. doi: 10.1097/01.ico.0000151503.26695.f0. PMID: 15829793
Recurrent Salzmann's corneal degeneration.
Severin M, Kirchhof B
Graefes Arch Clin Exp Ophthalmol 1990;228(2):101-4. doi: 10.1007/BF00935715. PMID: 2338247
Patterns of superficial keratopathy.
Roussel T, Grutzmacher R, Coster D
Aust J Ophthalmol 1984 Nov;12(4):301-16. doi: 10.1111/j.1442-9071.1984.tb01174.x. PMID: 6442135

Recent systematic reviews

Tears and Eyewear in Forensic Investigation-A Review.
Aparna R, Shanti Iyer R
Forensic Sci Int 2020 Jan;306:110055. Epub 2019 Nov 15 doi: 10.1016/j.forsciint.2019.110055. PMID: 31785512

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...