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Generalized hypopigmentation of hair

MedGen UID:
868986
•Concept ID:
C4023400
•
Disease or Syndrome
Synonym: Generalised hypopigmentation of hair
 
HPO: HP:0011358

Definition

Reduced pigmentation of hair diffusely. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGeneralized hypopigmentation of hair

Professional guidelines

PubMed

The Treatment of Refractory Vitiligo With Autologous Cultured Epithelium Grafting: A Real-World Retrospective Cohort Study.
Li J, Zeng X, Chen S, Tang L, Zhang Q, Lv M, Lian W, Wang J, Lv H, Liu Y, Shen J, Uyama T, Wu F, Wu J, Xu J
Stem Cells Transl Med 2024 May 14;13(5):415-424. doi: 10.1093/stcltm/szae009. PMID: 38513284Free PMC Article
Oculo-Cutaneous Albinism Type 4 (OCA4): Phenotype-Genotype Correlation.
Moreno-Artero E, Morice-Picard F, Lasseaux E, Robert MP, Coste V, Michaud V, Leclerc-Mercier S, Bremond-Gignac D, Arveiler B, Hadj-Rabia S
Genes (Basel) 2022 Nov 23;13(12) doi: 10.3390/genes13122198. PMID: 36553465Free PMC Article
Effect of narrowband ultraviolet B treatment on microRNA expression in active nonsegmental generalized vitiligo.
Parihar AS, Tembhre MK, Sharma VK, Gupta S, Chattopadhyay P, Deepak KK
Br J Dermatol 2020 Jul;183(1):167-169. Epub 2020 Mar 11 doi: 10.1111/bjd.18890. PMID: 31975367

Recent clinical studies

Etiology

Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients.
Kussainova A, Kassym L, Bekenova N, Akhmetova A, Glushkova N, Kussainov A, Urazalina Z, Yurkovskaya O, Smail Y, Pak L, Semenova Y
PLoS One 2022;17(7):e0271719. Epub 2022 Jul 29 doi: 10.1371/journal.pone.0271719. PMID: 35905107Free PMC Article
Male genital vitiligo.
Dauendorffer JN, Skayem C, Passeron T
Ann Dermatol Venereol 2022 Jun;149(2):92-98. Epub 2021 Jul 2 doi: 10.1016/j.annder.2021.06.003. PMID: 34226034
Skin pigmentation and its control: From ultraviolet radiation to stem cells.
Yardman-Frank JM, Fisher DE
Exp Dermatol 2021 Apr;30(4):560-571. Epub 2020 Dec 24 doi: 10.1111/exd.14260. PMID: 33320376Free PMC Article
Oculocutaneous albinism.
Grønskov K, Ek J, Brondum-Nielsen K
Orphanet J Rare Dis 2007 Nov 2;2:43. doi: 10.1186/1750-1172-2-43. PMID: 17980020Free PMC Article
Albinism: an update.
Orlow SJ
Semin Cutan Med Surg 1997 Mar;16(1):24-9. doi: 10.1016/s1085-5629(97)80032-6. PMID: 9125762

Diagnosis

Genetic etiology and clinical challenges of phenylketonuria.
Elhawary NA, AlJahdali IA, Abumansour IS, Elhawary EN, Gaboon N, Dandini M, Madkhali A, Alosaimi W, Alzahrani A, Aljohani F, Melibary EM, Kensara OA
Hum Genomics 2022 Jul 19;16(1):22. doi: 10.1186/s40246-022-00398-9. PMID: 35854334Free PMC Article
Ten clinical clues for the diagnosis of frontal fibrosing alopecia.
Melo DF, de Mattos Barreto T, de Souza Albernaz E, Haddad NC, Tortelly VD
Indian J Dermatol Venereol Leprol 2019 Sep-Oct;85(5):559-564. doi: 10.4103/ijdvl.IJDVL_713_17. PMID: 30073989
Elejalde syndrome (ES).
Mohammadzadeh Shanehsaz S, Rezazadeh A, Dandashli A
Dermatol Online J 2015 Feb 22;21(3) PMID: 25780981
KIT and mastocytosis.
Lim KH, Pardanani A, Tefferi A
Acta Haematol 2008;119(4):194-8. Epub 2008 Jun 20 doi: 10.1159/000140630. PMID: 18566536
Oculocutaneous albinism.
Grønskov K, Ek J, Brondum-Nielsen K
Orphanet J Rare Dis 2007 Nov 2;2:43. doi: 10.1186/1750-1172-2-43. PMID: 17980020Free PMC Article

Therapy

The Treatment of Refractory Vitiligo With Autologous Cultured Epithelium Grafting: A Real-World Retrospective Cohort Study.
Li J, Zeng X, Chen S, Tang L, Zhang Q, Lv M, Lian W, Wang J, Lv H, Liu Y, Shen J, Uyama T, Wu F, Wu J, Xu J
Stem Cells Transl Med 2024 May 14;13(5):415-424. doi: 10.1093/stcltm/szae009. PMID: 38513284Free PMC Article
Genetic etiology and clinical challenges of phenylketonuria.
Elhawary NA, AlJahdali IA, Abumansour IS, Elhawary EN, Gaboon N, Dandini M, Madkhali A, Alosaimi W, Alzahrani A, Aljohani F, Melibary EM, Kensara OA
Hum Genomics 2022 Jul 19;16(1):22. doi: 10.1186/s40246-022-00398-9. PMID: 35854334Free PMC Article
The Molecular Basis of Chemical Chaperone Therapy for Oculocutaneous Albinism Type 1A.
Teramae A, Kobayashi Y, Kunimoto H, Nakajima K, Suzuki T, Tsuruta D, Fukai K
J Invest Dermatol 2019 May;139(5):1143-1149. Epub 2018 Nov 14 doi: 10.1016/j.jid.2018.10.033. PMID: 30447237
Applications and efficacy of platelet-rich plasma in dermatology: A clinical review.
Zhang M, Park G, Zhou B, Luo D
J Cosmet Dermatol 2018 Oct;17(5):660-665. Epub 2018 Jul 25 doi: 10.1111/jocd.12673. PMID: 30047234
Lasers and light-based therapies in ethnic skin: treatment options and recommendations for Fitzpatrick skin types V and VI.
Alexis AF
Br J Dermatol 2013 Oct;169 Suppl 3:91-7. doi: 10.1111/bjd.12526. PMID: 24098905

Prognosis

Predictable and precise template-free CRISPR editing of pathogenic variants.
Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI
Nature 2018 Nov;563(7733):646-651. Epub 2018 Nov 7 doi: 10.1038/s41586-018-0686-x. PMID: 30405244Free PMC Article
Identification of Novel HLA-A*0201-Restricted CTL Epitopes in Chinese Vitiligo Patients.
Cui T, Yi X, Guo S, Zhou F, Liu L, Li C, Li K, Gao T
Sci Rep 2016 Nov 8;6:36360. doi: 10.1038/srep36360. PMID: 27821860Free PMC Article
Vitiligo: a review of the published work.
Yaghoobi R, Omidian M, Bagherani N
J Dermatol 2011 May;38(5):419-31. doi: 10.1111/j.1346-8138.2010.01139.x. PMID: 21667529
Griscelli syndrome.
Emanuel PO, Sternberg LJ, Phelps RG
Skinmed 2007 May-Jun;6(3):147-9. doi: 10.1111/j.1540-9740.2007.05783.x. PMID: 17483661
The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force.
Taïeb A, Picardo M; VETF Members
Pigment Cell Res 2007 Feb;20(1):27-35. doi: 10.1111/j.1600-0749.2006.00355.x. PMID: 17250545

Clinical prediction guides

Genetic insights into Tietz albinism-deafness syndrome: A new dominant-negative mutation in MITF.
Yamamoto K, Okamura K, Wakamatsu K, Ito S, Akabane K, Arai Y, Kawaguchi J, Hozumi Y, Suzuki T
Pigment Cell Melanoma Res 2024 Jul;37(4):430-437. Epub 2024 Mar 4 doi: 10.1111/pcmr.13166. PMID: 38439523
Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients.
Kussainova A, Kassym L, Bekenova N, Akhmetova A, Glushkova N, Kussainov A, Urazalina Z, Yurkovskaya O, Smail Y, Pak L, Semenova Y
PLoS One 2022;17(7):e0271719. Epub 2022 Jul 29 doi: 10.1371/journal.pone.0271719. PMID: 35905107Free PMC Article
Predictable and precise template-free CRISPR editing of pathogenic variants.
Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI
Nature 2018 Nov;563(7733):646-651. Epub 2018 Nov 7 doi: 10.1038/s41586-018-0686-x. PMID: 30405244Free PMC Article
Elejalde syndrome (ES).
Mohammadzadeh Shanehsaz S, Rezazadeh A, Dandashli A
Dermatol Online J 2015 Feb 22;21(3) PMID: 25780981
The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force.
Taïeb A, Picardo M; VETF Members
Pigment Cell Res 2007 Feb;20(1):27-35. doi: 10.1111/j.1600-0749.2006.00355.x. PMID: 17250545

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