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Abnormal circulating cytokine concentration

MedGen UID:
869117
•Concept ID:
C4023535
•
Finding
Synonym: Abnormality of serum cytokine level
 
HPO: HP:0011112

Definition

Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating cytokine concentration

Professional guidelines

PubMed

A Causal Treatment for X-Linked Hypohidrotic Ectodermal Dysplasia: Long-Term Results of Short-Term Perinatal Ectodysplasin A1 Replacement.
Schneider H, Schweikl C, Faschingbauer F, Hadj-Rabia S, Schneider P
Int J Mol Sci 2023 Apr 12;24(8) doi: 10.3390/ijms24087155. PMID: 37108325Free PMC Article
Infection-associated Immune Perturbations Resolve 1 Year Following Treatment for Loa loa.
Herrick JA, Makiya MA, Holland-Thomas N, Klion AD, Nutman TB
Clin Infect Dis 2021 Mar 1;72(5):789-796. doi: 10.1093/cid/ciaa137. PMID: 32055862Free PMC Article
Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis.
Bekersky I, Fitzsimmons W, Tanase A, Maher RM, Hodosh E, Lawrence I
J Am Acad Dermatol 2001 Jan;44(1 Suppl):S17-27. doi: 10.1067/mjd.2001.109816. PMID: 11145792

Recent clinical studies

Etiology

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design.
Groarke JD, Crawford J, Collins SM, Lubaczewski SL, Breen DM, Harrington MA, Jacobs I, Qiu R, Revkin J, Rossulek MI, Saxena AR
J Cachexia Sarcopenia Muscle 2024 Jun;15(3):1054-1061. Epub 2024 Mar 18 doi: 10.1002/jcsm.13435. PMID: 38500292Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.
Yu B, Liu L, Sun H, Chen Y
Int J Clin Exp Pathol 2015;8(9):10768-75. Epub 2015 Sep 1 PMID: 26617788Free PMC Article
Significance of circulating hepatocyte growth factor in protein-losing enteropathy after Fontan operation.
Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY
Pediatr Cardiol 2011 Oct;32(7):917-23. Epub 2011 Jun 11 doi: 10.1007/s00246-011-0014-9. PMID: 21667184

Diagnosis

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
IFN-α and TNF-α serum levels and their association with disease severity in Egyptian children and adults with alopecia areata.
Omar SI, Hamza AM, Eldabah N, Habiba DA
Int J Dermatol 2021 Nov;60(11):1397-1404. Epub 2021 May 18 doi: 10.1111/ijd.15658. PMID: 34008204
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity.
Kunz HE, Hart CR, Gries KJ, Parvizi M, Laurenti M, Dalla Man C, Moore N, Zhang X, Ryan Z, Polley EC, Jensen MD, Vella A, Lanza IR
Am J Physiol Endocrinol Metab 2021 Jul 1;321(1):E105-E121. Epub 2021 May 17 doi: 10.1152/ajpendo.00070.2021. PMID: 33998291Free PMC Article
The role of chemerin in the pathogenesis of cholelithiasis in children and adolescents.
Zdanowicz K, Ryzko J, Bobrus-Chociej A, Wojtkowska M, Lebensztejn DM
J Paediatr Child Health 2021 Mar;57(3):371-375. Epub 2020 Oct 11 doi: 10.1111/jpc.15223. PMID: 33043555
Placental delayed villous maturation is associated with evidence of chronic fetal hypoxia.
Jaiman S, Romero R, Pacora P, Jung EJ, Kacerovsky M, Bhatti G, Yeo L, Hsu CD
J Perinat Med 2020 Jun 25;48(5):516-518. doi: 10.1515/jpm-2020-0014. PMID: 32396141Free PMC Article

Therapy

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design.
Groarke JD, Crawford J, Collins SM, Lubaczewski SL, Breen DM, Harrington MA, Jacobs I, Qiu R, Revkin J, Rossulek MI, Saxena AR
J Cachexia Sarcopenia Muscle 2024 Jun;15(3):1054-1061. Epub 2024 Mar 18 doi: 10.1002/jcsm.13435. PMID: 38500292Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Significance of circulating hepatocyte growth factor in protein-losing enteropathy after Fontan operation.
Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY
Pediatr Cardiol 2011 Oct;32(7):917-23. Epub 2011 Jun 11 doi: 10.1007/s00246-011-0014-9. PMID: 21667184
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173

Prognosis

The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome.
Shariati A, Fallah F, Pormohammad A, Taghipour A, Safari H, Chirani AS, Sabour S, Alizadeh-Sani M, Azimi T
J Cell Physiol 2019 Jun;234(6):8550-8569. Epub 2018 Nov 27 doi: 10.1002/jcp.27828. PMID: 30480810
Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.
Yu B, Liu L, Sun H, Chen Y
Int J Clin Exp Pathol 2015;8(9):10768-75. Epub 2015 Sep 1 PMID: 26617788Free PMC Article
Significance of circulating hepatocyte growth factor in protein-losing enteropathy after Fontan operation.
Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY
Pediatr Cardiol 2011 Oct;32(7):917-23. Epub 2011 Jun 11 doi: 10.1007/s00246-011-0014-9. PMID: 21667184
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Clinical prediction guides

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design.
Groarke JD, Crawford J, Collins SM, Lubaczewski SL, Breen DM, Harrington MA, Jacobs I, Qiu R, Revkin J, Rossulek MI, Saxena AR
J Cachexia Sarcopenia Muscle 2024 Jun;15(3):1054-1061. Epub 2024 Mar 18 doi: 10.1002/jcsm.13435. PMID: 38500292Free PMC Article
Oat protein isolate-Pleurotus ostreatus β-glucan conjugate nanoparticles bound to β-carotene effectively alleviate immunosuppression by regulating gut microbiota.
Zhong L, Hu Q, Zhan Q, Zhao M, Zhao L
Food Funct 2024 Feb 19;15(4):1867-1883. doi: 10.1039/d3fo05158g. PMID: 38236028
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, Ren J
Cell Death Dis 2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9. PMID: 34218252Free PMC Article
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Long noncoding RNA AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway.
Yu B, Liu L, Sun H, Chen Y
Int J Clin Exp Pathol 2015;8(9):10768-75. Epub 2015 Sep 1 PMID: 26617788Free PMC Article

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials.
Dashti F, Mousavi SM, Larijani B, Esmaillzadeh A
Pharmacol Res 2021 Aug;170:105727. Epub 2021 Jun 11 doi: 10.1016/j.phrs.2021.105727. PMID: 34126229
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Chronic fatigue syndrome and circulating cytokines: A systematic review.
Blundell S, Ray KK, Buckland M, White PD
Brain Behav Immun 2015 Nov;50:186-195. Epub 2015 Jul 3 doi: 10.1016/j.bbi.2015.07.004. PMID: 26148446

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