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Paraplegia/paraparesis

MedGen UID:: 869366
•Concept ID:: C4023792
•: Disease or Syndrome

HPO:	HP:0010551

Definition

Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVParaplegia/paraparesis

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system physiology
    - Abnormal central motor function
      - Upper motor neuron dysfunction
        Weakness due to upper motor neuron dysfunction
        Paraplegia/paraparesis
        Paraparesis
        Spastic paraparesis
        Progressive spastic paraparesis
        Paraplegia
        Brown-Séquard syndrome
        Spastic paraplegia
        Progressive spastic paraplegia

Professional guidelines

PubMed

Systematic review and meta-analysis of current evidence in endograft therapy vs medical treatment for uncomplicated type B aortic dissection.

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485

Evidence-based guideline update: intraoperative spinal monitoring with somatosensory and transcranial electrical motor evoked potentials*.

Nuwer MR, Emerson RG, Galloway G, Legatt AD, Lopez J, Minahan R, Yamada T, Goodin DS, Armon C, Chaudhry V, Gronseth GS, Harden CL; American Association of Neuromuscular and Electrodiagnostic Medicine
J Clin Neurophysiol 2012 Feb;29(1):101-8. doi: 10.1097/WNP.0b013e31824a397e. PMID: 22353994

Evidence-based guideline update: intraoperative spinal monitoring with somatosensory and transcranial electrical motor evoked potentials: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Clinical Neurophysiology Society.

Nuwer MR, Emerson RG, Galloway G, Legatt AD, Lopez J, Minahan R, Yamada T, Goodin DS, Armon C, Chaudhry V, Gronseth GS, Harden CL; Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; American Clinical Neurophysiology Society
Neurology 2012 Feb 21;78(8):585-9. doi: 10.1212/WNL.0b013e318247fa0e. PMID: 22351796

See all (5)

Recent clinical studies

Etiology

Endovascular versus conventional open surgical repair for thoracoabdominal aortic aneurysms.

Sultan S, Concannon J, Veerasingam D, Tawfick W, McHugh P, Jordan F, Hynes N
Cochrane Database Syst Rev 2022 Apr 1;4(4):CD012926. doi: 10.1002/14651858.CD012926.pub2. PMID: 35363887 Free PMC Article

Neuraxial and peripheral misconnection events leading to wrong-route medication errors: a comprehensive literature review.

Viscusi ER, Hugo V, Hoerauf K, Southwick FS
Reg Anesth Pain Med 2021 Feb;46(2):176-181. Epub 2020 Nov 3 doi: 10.1136/rapm-2020-101836. PMID: 33144409 Free PMC Article

Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.

Coselli JS, LeMaire SA, Preventza O, de la Cruz KI, Cooley DA, Price MD, Stolz AP, Green SY, Arredondo CN, Rosengart TK
J Thorac Cardiovasc Surg 2016 May;151(5):1323-37. Epub 2016 Jan 14 doi: 10.1016/j.jtcvs.2015.12.050. PMID: 26898979

Surfer's myelopathy.

Thompson TP, Pearce J, Chang G, Madamba J
Spine (Phila Pa 1976) 2004 Aug 15;29(16):E353-6. doi: 10.1097/01.brs.0000134689.84162.e7. PMID: 15303045

Spastic paraplegia-paraparesis. A reappraisal.

Ungar-Sargon JY, Lovelace RE, Brust JC
J Neurol Sci 1980 Apr;46(1):1-12. doi: 10.1016/0022-510x(80)90039-8. PMID: 6154777

See all (55)

Diagnosis

One-Year Results of a Low-Profile Endograft in Acute, Complicated Type B Aortic Dissection.

Rossi PJ, Desai ND, Malaisrie SC, Lyden SP, Nassiri N, Reece TB, Adams JD, Moanie SL, Shults CC; RelayPro-D Investigators
Ann Thorac Surg 2024 Feb;117(2):336-343. Epub 2023 Sep 27 doi: 10.1016/j.athoracsur.2023.08.035. PMID: 37769702

Ischemic Spinal Cord Injury-Experimental Evidence and Evolution of Protective Measures.

Khachatryan Z, Haunschild J, von Aspern K, Borger MA, Etz CD
Ann Thorac Surg 2022 May;113(5):1692-1702. Epub 2021 Jan 9 doi: 10.1016/j.athoracsur.2020.12.028. PMID: 33434541

Acute type I aortic dissection with or without antegrade stent delivery: Mid-term outcomes.

Preventza O, Olive JK, Liao JL, Orozco-Sevilla V, Simpson K, Rodriguez MR, Price MD, Cheong BY, Chatterjee S, de la Cruz KI, Amarasekara HS, LeMaire SA, Coselli JS
J Thorac Cardiovasc Surg 2019 Nov;158(5):1273-1281. Epub 2019 Mar 9 doi: 10.1016/j.jtcvs.2018.11.145. PMID: 30955955

Surfer's myelopathy.

Thompson TP, Pearce J, Chang G, Madamba J
Spine (Phila Pa 1976) 2004 Aug 15;29(16):E353-6. doi: 10.1097/01.brs.0000134689.84162.e7. PMID: 15303045

Spastic paraplegia-paraparesis. A reappraisal.

Ungar-Sargon JY, Lovelace RE, Brust JC
J Neurol Sci 1980 Apr;46(1):1-12. doi: 10.1016/0022-510x(80)90039-8. PMID: 6154777

See all (17)

Therapy

Endovascular versus conventional open surgical repair for thoracoabdominal aortic aneurysms.

Sultan S, Concannon J, Veerasingam D, Tawfick W, McHugh P, Jordan F, Hynes N
Cochrane Database Syst Rev 2022 Apr 1;4(4):CD012926. doi: 10.1002/14651858.CD012926.pub2. PMID: 35363887 Free PMC Article

Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.

Current strategies for spinal cord protection during thoracic and thoracoabdominal aortic aneurysm repair.

Shimizu H, Yozu R
Gen Thorac Cardiovasc Surg 2011 Mar;59(3):155-63. Epub 2011 Mar 30 doi: 10.1007/s11748-010-0705-9. PMID: 21448790

Endovascular versus open repair for descending thoracic aortic rupture: institutional experience and meta-analysis.

Xenos ES, Minion DJ, Davenport DL, Hamdallah O, Abedi NN, Sorial EE, Endean ED
Eur J Cardiothorac Surg 2009 Feb;35(2):282-6. Epub 2008 Dec 10 doi: 10.1016/j.ejcts.2008.10.042. PMID: 19081731

Meta-analysis of endovascular vs open repair for traumatic descending thoracic aortic rupture.

Xenos ES, Abedi NN, Davenport DL, Minion DJ, Hamdallah O, Sorial EE, Endean ED
J Vasc Surg 2008 Nov;48(5):1343-51. Epub 2008 Jul 15 doi: 10.1016/j.jvs.2008.04.060. PMID: 18632242

See all (33)

Prognosis

Systematic review and meta-analysis of current evidence in endograft therapy vs medical treatment for uncomplicated type B aortic dissection.

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485

Early Gastrointestinal Complications After Open Thoracoabdominal Aortic Aneurysm Repair.

Frankel WC, Green SY, Amarasekara HS, Zhang Q, Preventza O, LeMaire SA, Coselli JS
Ann Thorac Surg 2021 Sep;112(3):717-724. Epub 2020 Nov 18 doi: 10.1016/j.athoracsur.2020.09.032. PMID: 33217404

Open Descending and Thoracoabdominal Aortic Repairs in Patients Younger Than 50 Years Old.

Tanaka A, Leonard SD, Sandhu HK, Afifi RO, Miller CC 3rd, Charlton-Ouw KM, Ray A, Hassan M, Safi HJ, Estrera AL
Ann Thorac Surg 2019 Sep;108(3):693-699. Epub 2019 Apr 19 doi: 10.1016/j.athoracsur.2019.03.058. PMID: 31009630

Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.

Outcome of patients with open and endovascular repair in acute complicated type B aortic dissection: a systematic review and meta-analysis of case series and comparative studies.

Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

See all (33)

Clinical prediction guides

Early Gastrointestinal Complications After Open Thoracoabdominal Aortic Aneurysm Repair.

Frankel WC, Green SY, Amarasekara HS, Zhang Q, Preventza O, LeMaire SA, Coselli JS
Ann Thorac Surg 2021 Sep;112(3):717-724. Epub 2020 Nov 18 doi: 10.1016/j.athoracsur.2020.09.032. PMID: 33217404

Acute type I aortic dissection with or without antegrade stent delivery: Mid-term outcomes.

Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.

Outcome of patients with open and endovascular repair in acute complicated type B aortic dissection: a systematic review and meta-analysis of case series and comparative studies.

Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

Meta-analysis of endovascular vs open repair for traumatic descending thoracic aortic rupture.

Xenos ES, Abedi NN, Davenport DL, Minion DJ, Hamdallah O, Sorial EE, Endean ED
J Vasc Surg 2008 Nov;48(5):1343-51. Epub 2008 Jul 15 doi: 10.1016/j.jvs.2008.04.060. PMID: 18632242

See all (33)

Recent systematic reviews

Systematic review and meta-analysis of current evidence in endograft therapy vs medical treatment for uncomplicated type B aortic dissection.

Wang J, Jin T, Chen B, Pan Y, Shao C
J Vasc Surg 2022 Oct;76(4):1099-1108.e3. Epub 2022 Apr 4 doi: 10.1016/j.jvs.2022.03.876. PMID: 35390485

Endovascular versus conventional open surgical repair for thoracoabdominal aortic aneurysms.

Sultan S, Concannon J, Veerasingam D, Tawfick W, McHugh P, Jordan F, Hynes N
Cochrane Database Syst Rev 2022 Apr 1;4(4):CD012926. doi: 10.1002/14651858.CD012926.pub2. PMID: 35363887 Free PMC Article

Outcome of patients with open and endovascular repair in acute complicated type B aortic dissection: a systematic review and meta-analysis of case series and comparative studies.

Luebke T, Brunkwall J
J Cardiovasc Surg (Torino) 2010 Oct;51(5):613-32. PMID: 20924323

See all (3)

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Paraplegia/paraparesis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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