U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of the sublingual glands

MedGen UID:
869491
•Concept ID:
C4023919
•
Anatomical Abnormality
HPO: HP:0010288

Definition

Any abnormality of the sublingual glands, which are the salivary glands that are located beneath the floor of the mouth anterior to the submandibular glands. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the sublingual glands

Professional guidelines

PubMed

Intracystic injection of pingyangmycin (PYM) might be a more favorable option for treatment of oral and plunging ranulas.
Yang XJ, Zheng JW, Zhou Q, Zhang SY, Yang C
Shanghai Kou Qiang Yi Xue 2010 Aug;19(4):447-8. PMID: 20871968

Recent clinical studies

Etiology

Delayed Sublingual Edema Following Neonatal Mandibular Distraction Osteogenesis.
Miller EM, Jungbauer WN Jr, Carroll WW, Pecha PP
J Craniofac Surg 2023 Sep 1;34(6):e612-e614. Epub 2023 Jul 27 doi: 10.1097/SCS.0000000000009554. PMID: 37497798
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Are the patients with anatomic variation of the sublingual/Wharton's duct system predisposed to ranula formation?
Zhang B, Yang Z, Zhang RM, Liu L, Zhang F, Chen J, Zhang K
Int J Pediatr Otorhinolaryngol 2016 Apr;83:69-73. Epub 2016 Jan 30 doi: 10.1016/j.ijporl.2016.01.026. PMID: 26968056
Spectrum of Human Foxe1/TTF2 Mutations.
Castanet M, Polak M
Horm Res Paediatr 2010;73(6):423-9. Epub 2010 May 6 doi: 10.1159/000281438. PMID: 20453517
Bilateral submandibular gland aplasia with hypertrophy of sublingual glands.
Mathison CC, Hudgins PA
Otolaryngol Head Neck Surg 2008 Jan;138(1):119-20. doi: 10.1016/j.otohns.2007.08.020. PMID: 18165008

Diagnosis

Hyalinizing clear cell carcinoma of the sublingual gland: A case report and literature review.
Guan L, Tang Y, Yang Z, Guo L, Yang S
Medicine (Baltimore) 2024 Jul 26;103(30):e39150. doi: 10.1097/MD.0000000000039150. PMID: 39058814Free PMC Article
Congenital Orocutaneous Fistula Associated With Ectopic Salivary Glands and Submandibular Gland Aplasia.
Trieu V, Hosseini DK, Kim GS, Truong MT, Cheng AG
Laryngoscope 2021 Mar;131(3):E998-E1001. Epub 2020 Jul 10 doi: 10.1002/lary.28921. PMID: 33059385
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195
THE SALIVARY GLANDS IN RADIOLOGICAL DIAGNOSIS.
GARUSI GF
Bibl Radiol 1964;4:1-160. PMID: 14060894

Therapy

Delayed Sublingual Edema Following Neonatal Mandibular Distraction Osteogenesis.
Miller EM, Jungbauer WN Jr, Carroll WW, Pecha PP
J Craniofac Surg 2023 Sep 1;34(6):e612-e614. Epub 2023 Jul 27 doi: 10.1097/SCS.0000000000009554. PMID: 37497798
Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study.
Boucher Y, Braud A, Dufour E, Agbo-Godeau S, Baaroun V, Descroix V, Guinnepain MT, Ungeheuer MN, Ottone C, Rougeot C
Clin Oral Investig 2017 Sep;21(7):2157-2164. Epub 2016 Nov 10 doi: 10.1007/s00784-016-1991-0. PMID: 27834029
The key role of newborn thyroid scintigraphy with isotopic iodide (123I) in defining and managing congenital hypothyroidism.
Schoen EJ, Clapp W, To TT, Fireman BH
Pediatrics 2004 Dec;114(6):e683-8. doi: 10.1542/peds.2004-0803. PMID: 15574601
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Lingual and sublingual thyroid glands in euthyroid children.
Hung W, Randolph JG, Sabatini D, Winship T
Pediatrics 1966 Oct;38(4):647-51. PMID: 5922182

Prognosis

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
New insight into ectopic thyroid glands between the neck and maxillofacial region from a 42-case study.
Gu T, Jiang B, Wang N, Xia F, Wang L, Gu A, Xu F, Han Y, Li Q, Lu Y
BMC Endocr Disord 2015 Nov 18;15:70. doi: 10.1186/s12902-015-0066-6. PMID: 26581587Free PMC Article
Sialendoscopic findings in patients with obstructive sialadenitis: long-term experience.
Chuangqi Y, Chi Y, Lingyan Z
Br J Oral Maxillofac Surg 2013 Jun;51(4):337-41. Epub 2012 Aug 9 doi: 10.1016/j.bjoms.2012.07.013. PMID: 22884848
Bilateral submandibular gland aplasia with hypertrophy of sublingual glands.
Mathison CC, Hudgins PA
Otolaryngol Head Neck Surg 2008 Jan;138(1):119-20. doi: 10.1016/j.otohns.2007.08.020. PMID: 18165008
Relations of the histopathology of sublingual and labial salivary glands to the clinical presentation in primary Sjögren's syndrome.
LeRoy JP, Pennec YL, Jouquan J, Lelong A, Youinou P
Clin Exp Rheumatol 1989 Mar-Apr;7(2):171-4. PMID: 2736831

Clinical prediction guides

Hyalinizing clear cell carcinoma of the sublingual gland: A case report and literature review.
Guan L, Tang Y, Yang Z, Guo L, Yang S
Medicine (Baltimore) 2024 Jul 26;103(30):e39150. doi: 10.1097/MD.0000000000039150. PMID: 39058814Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Are the patients with anatomic variation of the sublingual/Wharton's duct system predisposed to ranula formation?
Zhang B, Yang Z, Zhang RM, Liu L, Zhang F, Chen J, Zhang K
Int J Pediatr Otorhinolaryngol 2016 Apr;83:69-73. Epub 2016 Jan 30 doi: 10.1016/j.ijporl.2016.01.026. PMID: 26968056
Spectrum of Human Foxe1/TTF2 Mutations.
Castanet M, Polak M
Horm Res Paediatr 2010;73(6):423-9. Epub 2010 May 6 doi: 10.1159/000281438. PMID: 20453517
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

Recent systematic reviews

Sialodochostomy as treatment for imperforate submandibular duct: a systematic literature review and report of two cases.
Rosow DE, Ward RF, April MM
Int J Pediatr Otorhinolaryngol 2009 Dec;73(12):1613-5. Epub 2009 Apr 19 doi: 10.1016/j.ijporl.2009.03.007. PMID: 19380165

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...