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Imbalanced hemoglobin synthesis

MedGen UID:
870723
•Concept ID:
C4025177
•
Finding
Synonyms: Imbalanced haemoglobin synthesis; Imbalanced Hb synthesis
 
HPO: HP:0005560

Definition

Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImbalanced hemoglobin synthesis

Conditions with this feature

HEMOGLOBIN NYU
MedGen UID:
855075
•Concept ID:
C3889376
•
Finding
See: Condition Record
HEMOGLOBIN NYU

Recent clinical studies

Etiology

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
SIV infection aggravates malaria in a Chinese rhesus monkey coinfection model.
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications.
Xu J, Zhou Q, Liu G, Tan Y, Cai L
Oxid Med Cell Longev 2013;2013:635214. Epub 2013 Sep 22 doi: 10.1155/2013/635214. PMID: 24175012Free PMC Article
X-linked syndrome of platelet dysfunction, thrombocytopenia, and imbalanced globin chain synthesis with hemolysis.
Thompson AR, Wood WG, Stamatoyannopoulos G
Blood 1977 Aug;50(2):303-16. PMID: 871527

Diagnosis

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Red blood cells free α-haemoglobin pool: a biomarker to monitor the β-thalassemia intermedia variability. The ALPHAPOOL study.
Vasseur C, Domingues-Hamdi E, Ledudal K, Le Corvoisier P, Barau C, Ghaleh B, Rialland A, Pissard S, Galactéros F, Baudin-Creuza V
Br J Haematol 2017 Oct;179(1):142-153. Epub 2017 Jun 23 doi: 10.1111/bjh.14800. PMID: 28643346
The imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia.
Sun YX, Kong HL, Liu CF, Yu S, Tian T, Ma DX, Ji CY
Hum Immunol 2014 Feb;75(2):113-8. Epub 2013 Nov 20 doi: 10.1016/j.humimm.2013.11.014. PMID: 24269703
Occurrence of hereditary spherocytosis and beta thalassaemia in the same family: globin chain synthesis and visco diffractometric studies.
Pautard B, Feo C, Dhermy D, Wajcman H, Baudin-Chich V, Delobel J
Br J Haematol 1988 Oct;70(2):239-45. doi: 10.1111/j.1365-2141.1988.tb02470.x. PMID: 3191034
Embryonic erythroid differentiation in the human leukemic cell line K562.
Rutherford T, Clegg JB, Higgs DR, Jones RW, Thompson J, Weatherall DJ
Proc Natl Acad Sci U S A 1981 Jan;78(1):348-52. doi: 10.1073/pnas.78.1.348. PMID: 6264439Free PMC Article

Therapy

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Oral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical development.
Porter J, Taher A, Viprakasit V, Kattamis A, Coates TD, Garbowski M, Dürrenberger F, Manolova V, Richard F, Cappellini MD
Expert Rev Hematol 2021 Jul;14(7):633-644. Epub 2021 Jul 29 doi: 10.1080/17474086.2021.1935854. PMID: 34324404
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
SIV infection aggravates malaria in a Chinese rhesus monkey coinfection model.
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Therapeutic efficacy of different iron chelators in Egyptian children with Beta Thalassemia with iron overload.
Hagag AA, Hamam MA, Taha OA, Hazaa SM
Infect Disord Drug Targets 2015;15(2):98-105. doi: 10.2174/1871526515666150724111721. PMID: 26205801

Prognosis

SIV infection aggravates malaria in a Chinese rhesus monkey coinfection model.
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Care of patients with haemoglobin abnormalities: history and biology.
Khattab AD, Rawlings B, Ali IS
Br J Nurs 2006 Oct 12-25;15(18):994-8. doi: 10.12968/bjon.2006.15.18.22024. PMID: 17077770
A family with segregating triplicated alpha globin loci and beta thalassemia.
Galanello R, Ruggeri R, Paglietti E, Addis M, Melis MA, Cao A
Blood 1983 Nov;62(5):1035-40. PMID: 6313095
Hemoglobin Bart's in Northern Algeria.
Henni T, Bachir D, Tabone P, Jurdic P, Godet J, Colonna P
Acta Haematol 1981;65(4):240-6. doi: 10.1159/000207187. PMID: 6789587
Clinical and hematological evaluation of two delta 0 beta 0-thalassemia homozygotes.
Dincol G, Altay C, Aksoy M, Gurgey A, Felice AE, Huisman TH
Hemoglobin 1981;5(2):153-64. doi: 10.3109/03630268108996921. PMID: 6163753

Clinical prediction guides

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Oral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical development.
Porter J, Taher A, Viprakasit V, Kattamis A, Coates TD, Garbowski M, Dürrenberger F, Manolova V, Richard F, Cappellini MD
Expert Rev Hematol 2021 Jul;14(7):633-644. Epub 2021 Jul 29 doi: 10.1080/17474086.2021.1935854. PMID: 34324404
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
The imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia.
Sun YX, Kong HL, Liu CF, Yu S, Tian T, Ma DX, Ji CY
Hum Immunol 2014 Feb;75(2):113-8. Epub 2013 Nov 20 doi: 10.1016/j.humimm.2013.11.014. PMID: 24269703
Compensated variability in the expression of globin-related genes in erythroblasts generated ex vivo from different donors.
Varricchio L, Fabucci ME, Alfani E, Godbold J, Migliaccio AR
Transfusion 2010 Mar;50(3):672-84. Epub 2009 Nov 4 doi: 10.1111/j.1537-2995.2009.02483.x. PMID: 19891622

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