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Trichofolliculoma

MedGen UID:
87202
•Concept ID:
C0334262
•
Neoplastic Process
Synonym: Recurrent trichofolliculoma
SNOMED CT: Trichofolliculoma (274899008); Trichofolliculoma (33059009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019445
Orphanet: ORPHA864

Definition

A rare benign follicular hamartoma that develops primarily on the face of adults, with a particular predilection for the back of the nose, but also on the neck or scalp. It presents as a solitary hemispheric flesh-colored nodule with a central pore or black dot that may contain a tuft of hair. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrichofolliculoma
Follow this link to review classifications for Trichofolliculoma in Orphanet.

Professional guidelines

PubMed

CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.
Sengul D, Sengul I, Astarci MH, Ustun H, Mocan G
Pol J Pathol 2010;61(3):140-6. PMID: 21225496

Recent clinical studies

Etiology

Histopathological features of fibrous cephalic plaques in tuberous sclerosis complex.
Treichel AM, Pithadia DJ, Lee CR, Oyerinde O, Moss J, Darling TN
Histopathology 2021 Oct;79(4):619-628. Epub 2021 Jul 21 doi: 10.1111/his.14392. PMID: 33882161Free PMC Article
Benign follicular tumors.
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms.
Mertens RB, de Peralta-Venturina MN, Balzer BL, Frishberg DP
Am J Dermatopathol 2015 Dec;37(12):885-91. doi: 10.1097/DAD.0000000000000306. PMID: 26595821Free PMC Article
Hair follicle nevus in a 2-year old.
Motegi S, Amano H, Tamura A, Ishikawa O
Pediatr Dermatol 2008 Jan-Feb;25(1):60-2. doi: 10.1111/j.1525-1470.2007.00584.x. PMID: 18304156
Fine needle aspiration cytology of trichofolliculoma: a case report.
Alexander MP, Makhija P, Jayaseelan E
Indian J Pathol Microbiol 2007 Oct;50(4):870-2. PMID: 18306593

Diagnosis

A Chinese Patient with Eyelid Trichofolliculoma.
Guan J, Ye H, Yang H
Ophthalmology 2024 Sep;131(9):1063. Epub 2023 Nov 18 doi: 10.1016/j.ophtha.2023.10.003. PMID: 37978976
Giant Folliculosebaceous Cystic Hamartoma.
Zhong S, Lu H
J Cutan Med Surg 2023 Nov;27(6):672. Epub 2023 Sep 19 doi: 10.1177/12034754231199748. PMID: 37724915
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Benign follicular tumors.
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
TRICHOFOLLICULOMA.
PINKUS H, SUTTON RL Jr
Arch Dermatol 1965 Jan;91:46-9. doi: 10.1001/archderm.1965.01600070052005. PMID: 14229597

Therapy

Chronological changes in trichofolliculoma: Folliculosebaceous cystic hamartoma is not a very-late-stage trichofolliculoma.
Misago N, Ansai SI, Fukumoto T, Anan T, Kimura T, Nakao T
J Dermatol 2017 Sep;44(9):1050-1054. Epub 2017 Mar 31 doi: 10.1111/1346-8138.13842. PMID: 28370423
A revaluation of trichofolliculoma: the histopathological and immunohistochemical features.
Misago N, Kimura T, Toda S, Mori T, Narisawa Y
Am J Dermatopathol 2010 Feb;32(1):35-43. doi: 10.1097/DAD.0b013e3181a77414. PMID: 19730084
Recurrent trichofolliculoma of the upper eyelid margin.
Morton AD, Nelson CC, Headington JT, Elner VM
Ophthalmic Plast Reconstr Surg 1997 Dec;13(4):287-8. doi: 10.1097/00002341-199712000-00011. PMID: 9430308

Prognosis

Hair follicle nevus in a 2-year old.
Motegi S, Amano H, Tamura A, Ishikawa O
Pediatr Dermatol 2008 Jan-Feb;25(1):60-2. doi: 10.1111/j.1525-1470.2007.00584.x. PMID: 18304156
Benign ocular adnexal tumours of apocrine, eccrine or hair follicle origin.
Ozdal PC, Callejo SA, Codère F, Burnier MN Jr
Can J Ophthalmol 2003 Aug;38(5):357-63. doi: 10.1016/s0008-4182(03)80046-7. PMID: 12956276
Recurrent trichofolliculoma of the upper eyelid margin.
Morton AD, Nelson CC, Headington JT, Elner VM
Ophthalmic Plast Reconstr Surg 1997 Dec;13(4):287-8. doi: 10.1097/00002341-199712000-00011. PMID: 9430308

Clinical prediction guides

Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Chronological changes in trichofolliculoma: Folliculosebaceous cystic hamartoma is not a very-late-stage trichofolliculoma.
Misago N, Ansai SI, Fukumoto T, Anan T, Kimura T, Nakao T
J Dermatol 2017 Sep;44(9):1050-1054. Epub 2017 Mar 31 doi: 10.1111/1346-8138.13842. PMID: 28370423
Genital variant of folliculosebaceous cystic hamartoma.
Bolognia JL, Longley BJ
Dermatology 1998;197(3):258-60. doi: 10.1159/000018008. PMID: 9812032
Hair follicle nevus: case report and review.
Labandeira J, Peteiro C, Toribio J
Am J Dermatopathol 1996 Feb;18(1):90-3. doi: 10.1097/00000372-199602000-00015. PMID: 8721598
Involucrin expression in skin appendage tumours.
Hashimoto T, Inamoto N, Nakamura K, Harada R
Br J Dermatol 1987 Sep;117(3):325-32. doi: 10.1111/j.1365-2133.1987.tb04139.x. PMID: 3314967

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