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Adenocarcinoma with Spindle Cell Metaplasia

MedGen UID:
87233
•Concept ID:
C0334395
•
Neoplastic Process
Synonym: Adenocarcinoma with spindle cell metaplasia
SNOMED CT: Adenocarcinoma with spindle cell metaplasia (68358000)

Definition

An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma with Spindle Cell Metaplasia

Professional guidelines

PubMed

AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer.
Subramanian IV, Devineni S, Ghebre R, Ghosh G, Joshi HP, Jing Y, Truskinovsky AM, Ramakrishnan S
Gene Ther 2011 Feb;18(2):145-54. Epub 2010 Sep 16 doi: 10.1038/gt.2010.118. PMID: 20844568
Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma.
O'Hara BJ, Paetau A, Miettinen M
Hum Pathol 1998 Feb;29(2):119-26. doi: 10.1016/s0046-8177(98)90220-9. PMID: 9490269

Recent clinical studies

Etiology

The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
Mesenteric and Retroperitoneal Mucinous Cystic Neoplasms: A Case Series.
Van Treeck BJ, Horton RK, Lee HE, Rosty C, Pai RK, Graham RP
Int J Surg Pathol 2021 Sep;29(6):606-614. Epub 2021 Mar 18 doi: 10.1177/1066896921993536. PMID: 33736504
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature.
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Carcinoma of the thyroid: review of fifteen years' experience. 1. Origin of spindle and giant cell carcinoma. 2. Occurrence of thyroid cancer in ectopic thyroid tissue.
Maddox WA, Knott HW, Dowling EA
Am Surg 1971 Nov;37(11):653-60. PMID: 5119714

Diagnosis

Spindle cell variant of follicular thyroid carcinoma: An extremely unusual case and review of the literature.
Pusztaszeri MP, Florianova L, Payne R, Baloch ZW
Diagn Cytopathol 2022 Nov;50(11):E333-E338. Epub 2022 Jul 22 doi: 10.1002/dc.25018. PMID: 35866458
Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Metaplastic carcinoma of the breast with high grade spindle cell component with osteoid formation--a rare case report.
Singal R, Singh P, Sahu P, Mittal A, Naredi B, Gupta S
Acta Chir Belg 2011 Jul-Aug;111(4):243-5. PMID: 21954743
Carcinoma of the urinary bladder: a review of its diverse morphology.
Eble JN, Young RH
Semin Diagn Pathol 1997 May;14(2):98-108. PMID: 9179971

Therapy

A case of hepatoblastoma misdiagnosed as combined hepatocellular carcinoma and cholangiocarcinoma in an adult.
Park KW, Seo CJ, Yun DY, Kim MK, Kim BS, Han YS, Oh HK, Lee CH
Clin Mol Hepatol 2015 Sep;21(3):300-8. Epub 2015 Sep 30 doi: 10.3350/cmh.2015.21.3.300. PMID: 26523273Free PMC Article
AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer.
Subramanian IV, Devineni S, Ghebre R, Ghosh G, Joshi HP, Jing Y, Truskinovsky AM, Ramakrishnan S
Gene Ther 2011 Feb;18(2):145-54. Epub 2010 Sep 16 doi: 10.1038/gt.2010.118. PMID: 20844568
Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society.
Iwase H, Kurebayashi J, Tsuda H, Ohta T, Kurosumi M, Miyamoto K, Yamamoto Y, Iwase T
Breast Cancer 2010 Apr;17(2):118-24. Epub 2009 May 23 doi: 10.1007/s12282-009-0113-0. PMID: 19466512
Metaplastic breast carcinoma with melanocytic differentiation.
Bendic A, Bozic M, Durdov MG
Pathol Int 2009 Sep;59(9):676-80. doi: 10.1111/j.1440-1827.2009.02426.x. PMID: 19712138
Carcinosarcoma of the liver: a case report and review of the literature.
She R, Szakacs J
Arch Pathol Lab Med 2005 Jun;129(6):790-3. doi: 10.5858/2005-129-790-COTLAC. PMID: 15913431

Prognosis

Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia.
Zhang Y, Che N, Wang S, Meng J, Zhao N, Han J, Dong X, Li Y, Mo J, Zhao X, Liu T
J Gastroenterol 2024 Oct;59(10):941-957. Epub 2024 Aug 3 doi: 10.1007/s00535-024-02140-9. PMID: 39097533
A comprehensive overview of metaplastic breast cancer: Features and treatments.
Yan Q, Deng Y, Zhang Q
Cancer Sci 2024 Aug;115(8):2506-2514. Epub 2024 May 12 doi: 10.1111/cas.16208. PMID: 38735837Free PMC Article
The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Spindle and giant cell metaplasia in papillary carcinoma of the thyroid.
Hutter RV, Tollefsen HR, De Cosse JJ, Foote FW Jr, Frazell EL
Am J Surg 1965 Oct;110(4):660-8. doi: 10.1016/0002-9610(65)90057-7. PMID: 5825178

Clinical prediction guides

MISP Is Overexpressed in Intestinal Metaplasia and Gastric Cancer.
Vilarinho T, Pádua D, Pereira B, Mesquita P, Almeida R
Curr Oncol 2024 May 14;31(5):2769-2779. doi: 10.3390/curroncol31050210. PMID: 38785491Free PMC Article
The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
Fibromyxoid Nephrogenic Adenoma: A Series of 43 Cases Reassessing Predisposing Conditions, Clinical Presentation, and Morphology.
Li L, Williamson SR, Castillo RP, Delma KS, Gonzalgo ML, Epstein JI, Kryvenko ON
Am J Surg Pathol 2023 Jan 1;47(1):37-46. Epub 2022 Nov 4 doi: 10.1097/PAS.0000000000001986. PMID: 36395466
The role of the peritoneal microenvironment in the pathogenesis of colorectal peritoneal carcinomatosis.
Demuytere J, Ceelen W, Van Dorpe J, Hoorens A
Exp Mol Pathol 2020 Aug;115:104442. Epub 2020 Apr 17 doi: 10.1016/j.yexmp.2020.104442. PMID: 32305340
Increased alpha-B-crystallin expression in mammary metaplastic carcinomas.
Chan SK, Lui PC, Tan PH, Yamaguchi R, Moriya T, Yu AM, Shao MM, Hliang T, Wong SI, Tse GM
Histopathology 2011 Aug;59(2):247-55. doi: 10.1111/j.1365-2559.2011.03882.x. PMID: 21884203

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