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Superficial spreading melanoma

MedGen UID:
87242
•Concept ID:
C0334438
•
Neoplastic Process
Synonyms: Cutaneous Superficial Spreading Melanoma; cutaneous superficial spreading melanoma; Low-CSD Melanoma, SSM Subtype; Low-CSD Melanoma, Superficial Spreading Melanoma; Low-CSD Melanoma, Superficial Spreading Melanoma (SSM); Low-CSD Melanoma, Superficial Spreading Melanoma Subtype; Low-CSD Melanoma/SSM; Low-CSD Melanoma/Superficial Spreading Melanoma; pagetoid melanoma; SMM (superficial spreading melanoma) of skin; SMMM (superficial spreading malignant melanoma) of skin; SSM; SSM - Superficial spreading melanoma; SSMM - Superficial spreading melanoma; superficial spreading cutaneous (skin) melanoma; Superficial spreading malignant melanoma of skin; superficial spreading malignant melanoma of skin; superficial spreading malignant melanoma of the skin; superficial spreading malignant skin melanoma; Superficial Spreading Melanoma; superficial spreading melanoma; Superficial spreading melanoma of skin; superficial spreading melanoma of skin; Superficial Spreading Melanoma of the Skin; superficial spreading melanoma of the skin
SNOMED CT: SSM - Superficial spreading melanoma (55320002); SSMM - Superficial spreading melanoma (55320002); Superficial spreading malignant melanoma of skin (254730000); Superficial spreading melanoma of skin (254730000); SMM (superficial spreading melanoma) of skin (254730000); SMMM (superficial spreading malignant melanoma) of skin (254730000); Superficial spreading melanoma (55320002)
 
HPO: HP:0012057
Monarch Initiative: MONDO:0020638

Definition

A type of melanoma that is flat and irregular in shape and color, with different shades of black and brown. [from HPO]

Professional guidelines

PubMed

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Melanoma in Singapore: A 20-year review of disease and treatment outcomes.
Yeo PM, Lim ZV, Tan WDV, Zhao X, Chia HY, Tan SH, Teo MCC, Tan MWP
Ann Acad Med Singap 2021 Jun;50(6):456-466. doi: 10.47102/annals-acadmedsg.2020535. PMID: 34195752
Clinical and histological characteristics, and management of melanoma in French Guiana, 2007-2018.
Broly M, Drak Alsibai K, Cenciu B, Guevara H, Fayette J, Neidhardt EM, Demar M, Couppie P, Blaizot R
Int J Dermatol 2020 Aug;59(8):997-999. Epub 2020 Jun 7 doi: 10.1111/ijd.14961. PMID: 32506532Free PMC Article

Recent clinical studies

Etiology

Dermoscopic evaluation of superficial spreading melanoma.
Trindade FM, de Freitas MLP, Bittencourt FV
An Bras Dermatol 2021 Mar-Apr;96(2):139-147. Epub 2021 Feb 1 doi: 10.1016/j.abd.2020.06.012. PMID: 33637398Free PMC Article
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Melanomas.
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447
Superficial spreading melanoma.
D'Ath P, Thomson P
BMJ 2012 Apr 11;344:e2319. doi: 10.1136/bmj.e2319. PMID: 22496298
Malignant melanoma.
Runkle GP, Zaloznik AJ
Am Fam Physician 1994 Jan;49(1):91-8, 102-4. PMID: 8273727

Diagnosis

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Dermatoscopy of melanoma according to type, anatomic site and stage.
Lallas A, Paschou E, Manoli SM, Papageorgiou C, Spyridis I, Liopyris K, Bobos M, Moutsoudis A, Lazaridou E, Apalla Z
Ital J Dermatol Venerol 2021 Jun;156(3):274-288. Epub 2020 Dec 14 doi: 10.23736/S2784-8671.20.06784-X. PMID: 33314891
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Melanomas.
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447
Malignant melanoma.
Runkle GP, Zaloznik AJ
Am Fam Physician 1994 Jan;49(1):91-8, 102-4. PMID: 8273727

Therapy

Clinical Suspicion Sensitivity of Nodular and Superficial Spreading Melanoma.
Robsahm TE, Helsing P, Svendsen HL, Veierød MB
Acta Derm Venereol 2021 Apr 12;101(4):adv00427. doi: 10.2340/00015555-3782. PMID: 33686445Free PMC Article
Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy.
Lattanzi M, Lee Y, Simpson D, Moran U, Darvishian F, Kim RH, Hernando E, Polsky D, Hanniford D, Shapiro R, Berman R, Pavlick AC, Wilson MA, Kirchhoff T, Weber JS, Zhong J, Osman I
J Natl Cancer Inst 2019 Feb 1;111(2):180-188. doi: 10.1093/jnci/djy086. PMID: 29912415Free PMC Article
Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma.
Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ
J Am Acad Dermatol 2015 Jun;72(6):1036-46.e2. Epub 2015 Mar 25 doi: 10.1016/j.jaad.2015.02.1113. PMID: 25819940
Outcomes and prognostic factors in superficial spreading melanoma.
Egger ME, Stepp LO, Callender GG, Quillo AR, Martin RC 2nd, Scoggins CR, Stromberg AJ, McMasters KM
Am J Surg 2013 Dec;206(6):861-7; discussion 867-8. Epub 2013 Oct 1 doi: 10.1016/j.amjsurg.2013.09.003. PMID: 24124662
Superficial spreading melanoma.
D'Ath P, Thomson P
BMJ 2012 Apr 11;344:e2319. doi: 10.1136/bmj.e2319. PMID: 22496298

Prognosis

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Superficial spreading melanoma.
D'Ath P, Thomson P
BMJ 2012 Apr 11;344:e2319. doi: 10.1136/bmj.e2319. PMID: 22496298
Epigenetic marks in melanoma.
Richards HW, Medrano EE
Pigment Cell Melanoma Res 2009 Feb;22(1):14-29. Epub 2008 Nov 27 doi: 10.1111/j.1755-148X.2008.00534.x. PMID: 19040501
Malignant melanoma.
Runkle GP, Zaloznik AJ
Am Fam Physician 1994 Jan;49(1):91-8, 102-4. PMID: 8273727

Clinical prediction guides

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Clinical and histological characteristics, and management of melanoma in French Guiana, 2007-2018.
Broly M, Drak Alsibai K, Cenciu B, Guevara H, Fayette J, Neidhardt EM, Demar M, Couppie P, Blaizot R
Int J Dermatol 2020 Aug;59(8):997-999. Epub 2020 Jun 7 doi: 10.1111/ijd.14961. PMID: 32506532Free PMC Article
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Dermoscopic and clinical features of head and neck melanoma.
Cengiz FP, Cengiz AB, Emiroglu N, Comert E, Wellenhof RH
An Bras Dermatol 2015 Jul-Aug;90(4):488-93. doi: 10.1590/abd1806-4841.20153341. PMID: 26375217Free PMC Article
Dermoscopy of superficial spreading melanoma.
Obieta MP, Braun RP, Scope A, Rabinovitz H, Marghoob AA
G Ital Dermatol Venereol 2009 Feb;144(1):51-60. PMID: 19218911

Recent systematic reviews

The effect of menopausal hormone therapy on the risk of melanoma and keratinocyte skin cancer: A systematic review and meta-analysis of observational studies.
Lallas K, Anagnostis P, Theocharis P, Boureka E, Kyrgidis A, Klonos E, Papazisis G, Apalla Z, Lallas A, Vakirlis E
Maturitas 2023 Feb;168:20-28. Epub 2022 Nov 4 doi: 10.1016/j.maturitas.2022.10.010. PMID: 36372010
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
Frequency of mutations in BRAF, NRAS, and KIT in different populations and histological subtypes of melanoma: a systemic review.
Gutiérrez-Castañeda LD, Nova JA, Tovar-Parra JD
Melanoma Res 2020 Feb;30(1):62-70. doi: 10.1097/CMR.0000000000000628. PMID: 31274706Free PMC Article
A systematic review on external ear melanoma.
Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418
Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma.
Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ
J Am Acad Dermatol 2015 Jun;72(6):1036-46.e2. Epub 2015 Mar 25 doi: 10.1016/j.jaad.2015.02.1113. PMID: 25819940

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