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Pacinian tumor

MedGen UID:
87273
•Concept ID:
C0334599
•
Neoplastic Process
Synonyms: Pacinian neurofibroma; Pacinian Neurofibroma; Pacinian tumor (morphologic abnormality); Pacinian tumour (morphologic abnormality)
SNOMED CT: Pacinian neurofibroma (4230004); Pacinian neurofibroma (404033003); Pacinian tumor (4230004)
 
Monarch Initiative: MONDO:0002383

Definition

A neurofibroma characterized by the presence of structures which resemble Vater-Pacini corpuscles. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPacinian tumor

Professional guidelines

PubMed

The differential diagnosis between sclerotic fibroma and sclerosing perineurioma: An unresolved challenge.
Saggini A, Baciorri F
J Cutan Pathol 2020 Feb;47(2):195-196. Epub 2019 Dec 9 doi: 10.1111/cup.13620. PMID: 31782178

Recent clinical studies

Etiology

Vibrotactile perception in Dupuytren disease.
Held TL, Ahmadi M, Rajamani R, Barocas VH, Moeller AT
J Plast Surg Hand Surg 2021 Feb;55(1):32-40. Epub 2020 Oct 12 doi: 10.1080/2000656X.2020.1828898. PMID: 33043747
Pacinian corpuscles: an explanation for subcutaneous palmar nodules routinely encountered on MR examinations.
Rhodes NG, Murthy NS, Lehman JS, Rubin DA
Skeletal Radiol 2018 Nov;47(11):1553-1558. Epub 2018 Apr 9 doi: 10.1007/s00256-018-2934-4. PMID: 29632963
Neuronal involvement in cisplatin neuropathy: prospective clinical and neurophysiological studies.
Krarup-Hansen A, Helweg-Larsen S, Schmalbruch H, Rørth M, Krarup C
Brain 2007 Apr;130(Pt 4):1076-88. Epub 2007 Feb 14 doi: 10.1093/brain/awl356. PMID: 17301082
Keratoameloblastoma: a tumor sui generis or a chimera?
Whitt JC, Dunlap CL, Sheets JL, Thompson ML
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Sep;104(3):368-76. Epub 2006 Dec 4 doi: 10.1016/j.tripleo.2006.07.025. PMID: 17142069
Cutaneous sclerosing Pacinian-like perineurioma.
Burgues O, Monteagudo C, Noguera R, Revert A, Molina I, Llombart-Bosch A
Histopathology 2001 Nov;39(5):498-502. doi: 10.1046/j.1365-2559.2001.01251.x. PMID: 11737308

Diagnosis

Vibrotactile perception in Dupuytren disease.
Held TL, Ahmadi M, Rajamani R, Barocas VH, Moeller AT
J Plast Surg Hand Surg 2021 Feb;55(1):32-40. Epub 2020 Oct 12 doi: 10.1080/2000656X.2020.1828898. PMID: 33043747
Telocytes in the Normal and Pathological Peripheral Nervous System.
Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Gutiérrez E, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2020 Jun 17;21(12) doi: 10.3390/ijms21124320. PMID: 32560571Free PMC Article
Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review.
Fassola I, Wenzke L, Ertel W, Krasnici S
J Hand Surg Eur Vol 2019 Nov;44(9):925-931. Epub 2019 Jun 2 doi: 10.1177/1753193419852118. PMID: 31156019
Bilateral Nonsynchronous Pacinian Corpuscle Neuroma.
Jiménez I, Marcos-García A, Muratore G, Medina J
J Hand Surg Am 2018 Dec;43(12):1142.e1-1142.e4. Epub 2018 Apr 5 doi: 10.1016/j.jhsa.2018.03.007. PMID: 29627280
Spectrum of superficial nerve-related tumor and tumor-like lesions: MRI features.
Wadhwa V, Lee PP, Strome GM, Suh KJ, Carrino JA, Chhabra A
Acta Radiol 2014 Apr;55(3):345-58. Epub 2013 Jul 31 doi: 10.1177/0284185113494983. PMID: 23904089

Therapy

"Is this case of a very rare disease work-related?" A review of reported cases of Pacinian neuroma.
Zanardi F, Cooke RM, Maiorana A, Curti S, Farioli A, Bonfiglioli R, Violante FS, Mattioli S
Scand J Work Environ Health 2011 May;37(3):253-8. Epub 2010 Nov 17 doi: 10.5271/sjweh.3132. PMID: 21082159
Neuronal involvement in cisplatin neuropathy: prospective clinical and neurophysiological studies.
Krarup-Hansen A, Helweg-Larsen S, Schmalbruch H, Rørth M, Krarup C
Brain 2007 Apr;130(Pt 4):1076-88. Epub 2007 Feb 14 doi: 10.1093/brain/awl356. PMID: 17301082

Prognosis

Vibrotactile perception in Dupuytren disease.
Held TL, Ahmadi M, Rajamani R, Barocas VH, Moeller AT
J Plast Surg Hand Surg 2021 Feb;55(1):32-40. Epub 2020 Oct 12 doi: 10.1080/2000656X.2020.1828898. PMID: 33043747
The value of immunohistochemical studies using antibody to S100 protein in dermatopathology.
Kahn HJ, Baumal R, Marks A
Int J Dermatol 1984 Jan-Feb;23(1):38-44. doi: 10.1111/j.1365-4362.1984.tb05661.x. PMID: 6373634
Sacrococcygeal developmental abnormalities and tumors in children.
Bale PM
Perspect Pediatr Pathol 1984 Spring;8(1):9-56. PMID: 6366733
Pacinian neurofibroma.
MacDonald DM, Wilson-Jones E
Histopathology 1977 Jul;1(4):247-55. doi: 10.1111/j.1365-2559.1977.tb01664.x. PMID: 615838
Pacinian corpuscle neuroma of digital nerves.
Rhode CM, Jennings WD Jr
South Med J 1975 Jan;68(1):86-9. doi: 10.1097/00007611-197501000-00023. PMID: 1154066

Clinical prediction guides

Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis.
García-Martínez I, García-Mesa Y, García-Piqueras J, Martínez-Pubil A, Cobo JL, Feito J, García-Suárez O, Vega JA
J Anat 2022 May;240(5):972-984. Epub 2021 Dec 8 doi: 10.1111/joa.13609. PMID: 34881452Free PMC Article
Telocytes in the Normal and Pathological Peripheral Nervous System.
Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Gutiérrez E, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2020 Jun 17;21(12) doi: 10.3390/ijms21124320. PMID: 32560571Free PMC Article
Pacinian Corpuscles in Human Lymph Nodes.
Feito J, Cobo JL, Santos-Briz A, Vega JA
Anat Rec (Hoboken) 2017 Dec;300(12):2233-2238. Epub 2017 Aug 18 doi: 10.1002/ar.23679. PMID: 28806498
Pacinian Corpuscles Neuroma. An Exceptional Cause of Pain in the Hand.
Jiménez I, Marcos-García A, Muratore G, Medina J
J Hand Surg Asian Pac Vol 2017 Jun;22(2):229-231. doi: 10.1142/S0218810417720121. PMID: 28506166
Painful hyperplasia and hypertrophy of pacinian corpuscles in the hand: report of two cases with immunohistochemical and ultrastructural studies, and a review of the literature.
Reznik M, Thiry A, Fridman V
Am J Dermatopathol 1998 Apr;20(2):203-7. doi: 10.1097/00000372-199804000-00019. PMID: 9557793

Recent systematic reviews

Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review.
Fassola I, Wenzke L, Ertel W, Krasnici S
J Hand Surg Eur Vol 2019 Nov;44(9):925-931. Epub 2019 Jun 2 doi: 10.1177/1753193419852118. PMID: 31156019
"Is this case of a very rare disease work-related?" A review of reported cases of Pacinian neuroma.
Zanardi F, Cooke RM, Maiorana A, Curti S, Farioli A, Bonfiglioli R, Violante FS, Mattioli S
Scand J Work Environ Health 2011 May;37(3):253-8. Epub 2010 Nov 17 doi: 10.5271/sjweh.3132. PMID: 21082159

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