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Gastric fundus carcinoma

MedGen UID:
87514
•Concept ID:
C0345799
•
Neoplastic Process
Synonyms: Cancer of Fundus of Stomach; Cancer of Gastric Fundus; Cancer of the Fundus of the Stomach; Cancer of the Gastric Fundus; Carcinoma of fundus of stomach; Carcinoma of Fundus of Stomach; carcinoma of fundus of stomach; Carcinoma of Gastric Fundus; carcinoma of gastric fundus; Carcinoma of the Fundus of the Stomach; carcinoma of the fundus of the stomach; Carcinoma of the Gastric Fundus; carcinoma of the gastric fundus; fundus of stomach carcinoma; Gastric Fundus Cancer; gastric fundus cancer; Gastric Fundus Carcinoma; gastric fundus carcinoma
SNOMED CT: Carcinoma of fundus of stomach (254555008)
 
Monarch Initiative: MONDO:0003970

Definition

A carcinoma that arises from the fundus of the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric fundus carcinoma

Professional guidelines

PubMed

Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Emerging evidence supports grouping by location of early gastric carcinoma for appropriate clinical management in Chinese patients.
Huang Q, Li R, Xu GF, Zhou D, Fan XS, Zou XP
J Dig Dis 2018 Dec;19(12):730-736. Epub 2018 Nov 14 doi: 10.1111/1751-2980.12674. PMID: 30270559
Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999

Recent clinical studies

Etiology

Fundic gland adenocarcinoma.
Goel A, Agrawal K, Mukherjee U, Singla V
BMJ Case Rep 2024 Dec 3;17(12) doi: 10.1136/bcr-2024-261983. PMID: 39631917
Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Gastric Carcinoma in Autoimmune Gastritis: A Histopathologic and Molecular Study.
Angerilli V, Vanoli A, Celin G, Ceccon C, Gasparello J, Sabbadin M, De Lisi G, Paudice M, Lenti MV, Rovedatti L, Di Sabatino A, Bazzocchi F, Lonardi S, Savarino E, Luchini C, Parente P, Grillo F, Mastracci L, Fassan M
Mod Pathol 2024 Jun;37(6):100491. Epub 2024 Apr 6 doi: 10.1016/j.modpat.2024.100491. PMID: 38588886
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347
Upper gastrointestinal manifestations in families with hereditary flat adenoma syndrome.
Lynch HT, Smyrk TC, Lanspa SJ, Jenkins JX, Lynch PM, Cavalieri J, Lynch JF
Cancer 1993 May 1;71(9):2709-14. doi: 10.1002/1097-0142(19930501)71:9<2709::aid-cncr2820710904>3.0.co;2-t. PMID: 8385563

Diagnosis

Fundic gland adenocarcinoma.
Goel A, Agrawal K, Mukherjee U, Singla V
BMJ Case Rep 2024 Dec 3;17(12) doi: 10.1136/bcr-2024-261983. PMID: 39631917
Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Gastric sarcomatoid carcinoma.
Carboni F, Levi Sandri GB, Valle M, Covello R, Garofalo A
J Gastrointest Surg 2013 Nov;17(11):2025-7. doi: 10.1007/s11605-013-2310-6. PMID: 23959693

Therapy

Delayed diaphragmatic hernia and gastric fundus incarceration: a rare complication after transarterial chemoembolization.
Goh SK, Naazar A, Issa M, Starkey G, Ranatunga D, Lee E
ANZ J Surg 2022 Jul;92(7-8):1882-1884. Epub 2021 Oct 17 doi: 10.1111/ans.17295. PMID: 34657385
Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma.
Coyne JD, Thampy S
Int J Surg Pathol 2021 Aug;29(5):503-505. Epub 2021 Apr 7 doi: 10.1177/1066896921994183. PMID: 33827319
Primary gastric small cell carcinoma.
Bilal M, Simoes C, Al-Hanayneh M, Shabot JM
Dig Liver Dis 2017 Jun;49(6):715. Epub 2017 Mar 10 doi: 10.1016/j.dld.2017.02.020. PMID: 28363459
Helicobacter pylori resistance to clarithromycin in Reunion Island.
Zemali N, Guillemot G, Jaubert J, Picot S, Thomas E, Becquart JP, Camuset G, Gérardin P, Michault A, Kwiatek S
Med Mal Infect 2016 Oct;46(7):385-389. Epub 2016 Jul 15 doi: 10.1016/j.medmal.2016.06.004. PMID: 27427280
Upper gastrointestinal manifestations in families with hereditary flat adenoma syndrome.
Lynch HT, Smyrk TC, Lanspa SJ, Jenkins JX, Lynch PM, Cavalieri J, Lynch JF
Cancer 1993 May 1;71(9):2709-14. doi: 10.1002/1097-0142(19930501)71:9<2709::aid-cncr2820710904>3.0.co;2-t. PMID: 8385563

Prognosis

Fundic gland adenocarcinoma.
Goel A, Agrawal K, Mukherjee U, Singla V
BMJ Case Rep 2024 Dec 3;17(12) doi: 10.1136/bcr-2024-261983. PMID: 39631917
Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms.
Han D, Li YL, Zhou ZW, Yin F, Chen J, Liu F, Shi YF, Wang W, Zhang Y, Yu XJ, Xu JM, Yang RX, Tian C, Luo J, Tan HY
World J Gastroenterol 2021 Jun 7;27(21):2895-2909. doi: 10.3748/wjg.v27.i21.2895. PMID: 34135560Free PMC Article
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
A Case Report: Endoscopic Diagnosis and Treatment of Gastric Adenocarcinoma of Fundic Gland Type.
Peng T, Deng L, Hou L, Wang Y, Wang R, Gao R, Ye X
J Gastrointest Cancer 2020 Jun;51(2):673-676. doi: 10.1007/s12029-020-00360-9. PMID: 31930448
Gastric sarcomatoid carcinoma.
Carboni F, Levi Sandri GB, Valle M, Covello R, Garofalo A
J Gastrointest Surg 2013 Nov;17(11):2025-7. doi: 10.1007/s11605-013-2310-6. PMID: 23959693

Clinical prediction guides

Gastric Carcinoma in Autoimmune Gastritis: A Histopathologic and Molecular Study.
Angerilli V, Vanoli A, Celin G, Ceccon C, Gasparello J, Sabbadin M, De Lisi G, Paudice M, Lenti MV, Rovedatti L, Di Sabatino A, Bazzocchi F, Lonardi S, Savarino E, Luchini C, Parente P, Grillo F, Mastracci L, Fassan M
Mod Pathol 2024 Jun;37(6):100491. Epub 2024 Apr 6 doi: 10.1016/j.modpat.2024.100491. PMID: 38588886
Collision Tumors of Gastric Adenocarcinoma and Mucosa-associated Lymphoid Tissue Lymphoma.
Kobayashi K, Furukawa K, Ishikawa E, Mitsuma A, Funasaka K, Kakushima N, Furune S, Ito N, Wada H, Hirose T, Muroi K, Suzuki T, Suzuki T, Hida E, Hirai K, Shibata H, Koya T, Nakamura M, Kawashima H, Miyahara R, Fujishiro M
Intern Med 2021;60(15):2419-2424. Epub 2021 Aug 1 doi: 10.2169/internalmedicine.6124-20. PMID: 34334591Free PMC Article
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Helicobacter pylori resistance to clarithromycin in Reunion Island.
Zemali N, Guillemot G, Jaubert J, Picot S, Thomas E, Becquart JP, Camuset G, Gérardin P, Michault A, Kwiatek S
Med Mal Infect 2016 Oct;46(7):385-389. Epub 2016 Jul 15 doi: 10.1016/j.medmal.2016.06.004. PMID: 27427280

Recent systematic reviews

Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis.
Tran-Duy A, Spaetgens B, Hoes AW, de Wit NJ, Stehouwer CD
Clin Gastroenterol Hepatol 2016 Dec;14(12):1706-1719.e5. Epub 2016 May 20 doi: 10.1016/j.cgh.2016.05.018. PMID: 27211501

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