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Metastatic Malignant Neoplasm in the Testis

MedGen UID:
87567
•Concept ID:
C0347003
•
Neoplastic Process
Synonyms: Metastasis to testis; Metastatic malignant neoplasm of testis; Metastatic malignant neoplasm to testis; Metastatic Malignant Neoplasm to the Testis; Metastatic Neoplasm to the Testis; Metastatic tumor to testis; Metastatic Tumor to the Testis; Secondary malignant neoplasm of testis
SNOMED CT: Metastatic tumor to testis (94623007); Metastasis to testis (94623007); Secondary malignant neoplasm of testis (94623007); Metastatic malignant neoplasm to testis (94623007); Metastatic malignant neoplasm of testis (94623007)

Definition

A malignant neoplasm that has spread to the testis from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Testis

Professional guidelines

PubMed

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

European Association of Urology Guidelines on Testicular Cancer: 2023 Update.
Patrikidou A, Cazzaniga W, Berney D, Boormans J, de Angst I, Di Nardo D, Fankhauser C, Fischer S, Gravina C, Gremmels H, Heidenreich A, Janisch F, Leão R, Nicolai N, Oing C, Oldenburg J, Shepherd R, Tandstad T, Nicol D
Eur Urol 2023 Sep;84(3):289-301. Epub 2023 May 12 doi: 10.1016/j.eururo.2023.04.010. PMID: 37183161
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528
Testicular cancer update.
Adra N, Einhorn LH
Clin Adv Hematol Oncol 2017 May;15(5):386-396. PMID: 28591093

Diagnosis

Testicular Tumors.
Krege S, Oing C, Bokemeyer C
Dtsch Arztebl Int 2023 Dec 8;120(49):843-854. doi: 10.3238/arztebl.m2023.0143. PMID: 37378600Free PMC Article
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423

Therapy

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA
J Clin Invest 2020 Nov 2;130(11):5976-5988. doi: 10.1172/JCI134915. PMID: 33016924Free PMC Article
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1.
Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CC, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA
J Clin Oncol 2011 Mar 1;29(7):917-24. Epub 2011 Jan 31 doi: 10.1200/JCO.2010.32.2537. PMID: 21282551Free PMC Article
Advanced testis cancer.
Droz JP, Rivoire M
Curr Treat Options Oncol 2001 Oct;2(5):421-9. doi: 10.1007/s11864-001-0047-z. PMID: 12057105
Testicular cancer.
Garnick MB
Semin Surg Oncol 1989;5(4):221-6. doi: 10.1002/ssu.2980050403. PMID: 2672228

Prognosis

Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Advanced testis cancer.
Droz JP, Rivoire M
Curr Treat Options Oncol 2001 Oct;2(5):421-9. doi: 10.1007/s11864-001-0047-z. PMID: 12057105
Early-stage testis cancer.
Foster RS
Curr Treat Options Oncol 2001 Oct;2(5):413-9. doi: 10.1007/s11864-001-0046-0. PMID: 12057104
Testicular lymphoma.
Shahab N, Doll DC
Semin Oncol 1999 Jun;26(3):259-69. PMID: 10375083

Clinical prediction guides

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA
J Clin Invest 2020 Nov 2;130(11):5976-5988. doi: 10.1172/JCI134915. PMID: 33016924Free PMC Article
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1.
Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CC, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA
J Clin Oncol 2011 Mar 1;29(7):917-24. Epub 2011 Jan 31 doi: 10.1200/JCO.2010.32.2537. PMID: 21282551Free PMC Article
Testicular cancer.
Oliver RT
Curr Opin Oncol 2001 May;13(3):191-8. doi: 10.1097/00001622-200105000-00011. PMID: 11307064
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Recent systematic reviews

Significance of PD-L1 in Metastatic Urothelial Carcinoma Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
Maiorano BA, Di Maio M, Cerbone L, Maiello E, Procopio G, Roviello G; MeetURO Group
JAMA Netw Open 2024 Mar 4;7(3):e241215. doi: 10.1001/jamanetworkopen.2024.1215. PMID: 38446479Free PMC Article
Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study.
Cazzato G, Mangialardi K, Falcicchio G, Colagrande A, Ingravallo G, Arezzo F, Giliberti G, Trilli I, Loizzi V, Lettini T, Scarcella S, Annese T, Parente P, Lupo C, Casatta N, Maiorano E, Cormio G, Resta L, Ribatti D
Genes (Basel) 2022 Mar 19;13(3) doi: 10.3390/genes13030545. PMID: 35328098Free PMC Article
Expression of cancer/testis antigens in cutaneous melanoma: a systematic review.
Tio D, Kasiem FR, Willemsen M, van Doorn R, van der Werf N, Hoekzema R, Luiten RM, Bekkenk MW
Melanoma Res 2019 Aug;29(4):349-357. doi: 10.1097/CMR.0000000000000569. PMID: 30615012
The contemporary role of chemotherapy for advanced testis cancer: a systematic review of the literature.
Calabrò F, Albers P, Bokemeyer C, Martin C, Einhorn LH, Horwich A, Krege S, Schmoll HJ, Sternberg CN, Daugaard G
Eur Urol 2012 Jun;61(6):1212-21. Epub 2012 Mar 24 doi: 10.1016/j.eururo.2012.03.038. PMID: 22464311
Screening for testicular cancer.
Ilic D, Misso ML
Cochrane Database Syst Rev 2011 Feb 16;(2):CD007853. doi: 10.1002/14651858.CD007853.pub2. PMID: 21328302

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