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Malignant Neoplasm of Multiple Primary Sites

MedGen UID:
87640
•Concept ID:
C0362051
•
Neoplastic Process
Synonyms: Malignant neoplasms of independent primary multiple sites; Primary malignant neoplasm of independent multiple sites; Primary multicentric tumor
SNOMED CT: Primary malignant neoplasm of independent multiple sites (109359008); Primary multicentric tumor (109359008); Malignant neoplasms of independent primary multiple sites (109359008)

Definition

A malignant neoplasm arising in multiple primary sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm of Multiple Primary Sites

Professional guidelines

PubMed

Treatment of Oligometastatic Non-Small Cell Lung Cancer: An ASTRO/ESTRO Clinical Practice Guideline.
Iyengar P, All S, Berry MF, Boike TP, Bradfield L, Dingemans AC, Feldman J, Gomez DR, Hesketh PJ, Jabbour SK, Jeter M, Josipovic M, Lievens Y, McDonald F, Perez BA, Ricardi U, Ruffini E, De Ruysscher D, Saeed H, Schneider BJ, Senan S, Widder J, Guckenberger M
Pract Radiat Oncol 2023 Sep-Oct;13(5):393-412. Epub 2023 Apr 25 doi: 10.1016/j.prro.2023.04.004. PMID: 37294262
Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions.
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Recent clinical studies

Etiology

Epidemiology of bone metastases.
Ryan C, Stoltzfus KC, Horn S, Chen H, Louie AV, Lehrer EJ, Trifiletti DM, Fox EJ, Abraham JA, Zaorsky NG
Bone 2022 May;158:115783. Epub 2020 Dec 1 doi: 10.1016/j.bone.2020.115783. PMID: 33276151
Temporal trends in the risk of developing multiple primary cancers: a systematic review.
Ye Y, Neil AL, Wills KE, Venn AJ
BMC Cancer 2016 Nov 4;16(1):849. doi: 10.1186/s12885-016-2876-y. PMID: 27814758Free PMC Article
Osteosarcomatosis.
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The carcinoid tumour.
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Diagnosis

Epidemiology of bone metastases.
Ryan C, Stoltzfus KC, Horn S, Chen H, Louie AV, Lehrer EJ, Trifiletti DM, Fox EJ, Abraham JA, Zaorsky NG
Bone 2022 May;158:115783. Epub 2020 Dec 1 doi: 10.1016/j.bone.2020.115783. PMID: 33276151
Primary mucosal melanoma.
Patrick RJ, Fenske NA, Messina JL
J Am Acad Dermatol 2007 May;56(5):828-34. Epub 2007 Mar 8 doi: 10.1016/j.jaad.2006.06.017. PMID: 17349716
Immunodeficiency-associated lymphoproliferative disorders.
Knowles DM
Mod Pathol 1999 Feb;12(2):200-17. PMID: 10071343
Pseudomyxoma peritonei.
Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579
Tumor antigens.
Urban JL, Schreiber H
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Therapy

Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer.
Hawley JE, Obradovic AZ, Dallos MC, Lim EA, Runcie K, Ager CR, McKiernan J, Anderson CB, Decastro GJ, Weintraub J, Virk R, Lowy I, Hu J, Chaimowitz MG, Guo XV, Zhang Y, Haffner MC, Worley J, Stein MN, Califano A, Drake CG
Cancer Cell 2023 Nov 13;41(11):1972-1988.e5. Epub 2023 Nov 2 doi: 10.1016/j.ccell.2023.10.006. PMID: 37922910Free PMC Article
Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study.
Qin S, Chan SL, Gu S, Bai Y, Ren Z, Lin X, Chen Z, Jia W, Jin Y, Guo Y, Hu X, Meng Z, Liang J, Cheng Y, Xiong J, Ren H, Yang F, Li W, Chen Y, Zeng Y, Sultanbaev A, Pazgan-Simon M, Pisetska M, Melisi D, Ponomarenko D, Osypchuk Y, Sinielnikov I, Yang TS, Liang X, Chen C, Wang L, Cheng AL, Kaseb A, Vogel A; CARES-310 Study Group
Lancet 2023 Sep 30;402(10408):1133-1146. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00961-3. PMID: 37499670
Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial.
Tang C, Sherry AD, Haymaker C, Bathala T, Liu S, Fellman B, Cohen L, Aparicio A, Zurita AJ, Reuben A, Marmonti E, Chun SG, Reddy JP, Ghia A, McGuire S, Efstathiou E, Wang J, Wang J, Pilie P, Kovitz C, Du W, Simiele SJ, Kumar R, Borghero Y, Shi Z, Chapin B, Gomez D, Wistuba I, Corn PG
JAMA Oncol 2023 Jun 1;9(6):825-834. doi: 10.1001/jamaoncol.2023.0161. PMID: 37022702Free PMC Article
Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial.
Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, Li QS, Gallagher RM, Kantoff PW
JAMA Oncol 2021 May 1;7(5):720-727. doi: 10.1001/jamaoncol.2021.0310. PMID: 33734288Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Prognosis

ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
Arrillaga-Romany I, Lassman A, McGovern SL, Mueller S, Nabors B, van den Bent M, Vogelbaum MA, Allen JE, Melemed AS, Tarapore RS, Wen PY, Cloughesy T
Neuro Oncol 2024 May 3;26(Supplement_2):S173-S181. doi: 10.1093/neuonc/noae031. PMID: 38445964Free PMC Article
Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2).
Zhao WH, Wang BY, Chen LJ, Fu WJ, Xu J, Liu J, Jin SW, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, Gu LF, Wang JL, Zhang H, Bai J, Xu Y, Zhu H, Du J, Jiang H, Fan XH, Li JY, Hou J, Chen Z, Zhang WG, Mi JQ, Chen SJ, He AL
J Hematol Oncol 2022 Jul 6;15(1):86. doi: 10.1186/s13045-022-01301-8. PMID: 35794616Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma.
Feller L, Khammissa RAG, Lemmer J
ScientificWorldJournal 2017;2017:9189812. Epub 2017 May 30 doi: 10.1155/2017/9189812. PMID: 28638859Free PMC Article
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
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Clinical prediction guides

Understanding the increasing incidence of neuroendocrine tumors.
Pathak S, Starr JS, Halfdanarson T, Sonbol MB
Expert Rev Endocrinol Metab 2023 Sep-Nov;18(5):377-385. Epub 2023 Jul 19 doi: 10.1080/17446651.2023.2237593. PMID: 37466336
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Adiposity and cancer at major anatomical sites: umbrella review of the literature.
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article
Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection.
Smalley SR, Benedetti JK, Haller DG, Hundahl SA, Estes NC, Ajani JA, Gunderson LL, Goldman B, Martenson JA, Jessup JM, Stemmermann GN, Blanke CD, Macdonald JS
J Clin Oncol 2012 Jul 1;30(19):2327-33. Epub 2012 May 14 doi: 10.1200/JCO.2011.36.7136. PMID: 22585691Free PMC Article

Recent systematic reviews

Transitional Care Navigation.
Rodriguez AL, Cappelletti L, Kurian SM, Passio C, Rux S
Semin Oncol Nurs 2024 Apr;40(2):151580. Epub 2024 Jan 29 doi: 10.1016/j.soncn.2024.151580. PMID: 38290928
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document.
Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward WA
Radiother Oncol 2020 Jul;148:157-166. Epub 2020 Apr 22 doi: 10.1016/j.radonc.2020.04.003. PMID: 32388150
Adiposity and cancer at major anatomical sites: umbrella review of the literature.
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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