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Lepidic Adenocarcinoma

MedGen UID:
883345
•Concept ID:
C4049711
•
Neoplastic Process
Synonyms: Lepidic Predominant Adenocarcinoma; Lepidic Predominant Lung Adenocarcinoma

Definition

A lung adenocarcinoma characterized by the presence of mildly and moderately differentiated adenocarcinoma cells across the alveolar walls with at least one focus of invasive carcinoma measuring more than 5 mm in greatest dimension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLepidic Adenocarcinoma

Professional guidelines

PubMed

EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.
Zhao R, Li J, Guo L, Xiang C, Chen S, Zhao J, Shao J, Zhu L, Ye M, Qin G, Chu T, Han Y
Target Oncol 2024 Mar;19(2):277-288. Epub 2024 Feb 28 doi: 10.1007/s11523-024-01042-3. PMID: 38416376
New Morphologic Findings Support Invasiveness Criteria in Small-Sized Nonmucinous Lepidic Adenocarcinoma: Commenting a Proposal From the International Association for the Study of Lung Cancer Pathology Committee.
Visca P, Gallo E, Marino M
J Thorac Oncol 2023 Apr;18(4):387-389. doi: 10.1016/j.jtho.2023.01.001. PMID: 36990568
Pulmonary Adenocarcinomas of Low Malignant Potential: Proposed Criteria to Expand the Spectrum Beyond Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma.
Yambayev I, Sullivan TB, Suzuki K, Zhao Q, Higgins SE, Yilmaz OH, Litle VR, Moreira P, Servais EL, Stock CT, Quadri SM, Williamson C, Rieger-Christ KM, Burks EJ
Am J Surg Pathol 2021 Apr 1;45(4):567-576. doi: 10.1097/PAS.0000000000001618. PMID: 33177339

Recent clinical studies

Etiology

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.
Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908
Commentary: Nodal Assessment in Lepidic Adenocarcinoma: Less is not More.
Starnes SL
Semin Thorac Cardiovasc Surg 2023 Summer;35(2):410-411. Epub 2022 Apr 2 doi: 10.1053/j.semtcvs.2022.03.007. PMID: 35381353
Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.
Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329Free PMC Article
Approach to the Subsolid Nodule.
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Is chemotherapy rechallenge feasible in advanced-stage non-small-cell lung cancer?
Mignard X, Ruppert AM, Lavolé A, Vieira T, Rozensztajn N, Cadranel J, Wislez M
Bull Cancer 2019 Sep;106(9):725-733. Epub 2019 Jun 13 doi: 10.1016/j.bulcan.2019.04.010. PMID: 31202557

Diagnosis

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.
Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908
Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.
Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329Free PMC Article
A Severe COVID-19 Pneumonia Revealing a Lepidic Adenocarcinoma: A Diagnostic Challenge during the Pandemic Period.
Elabbadi A, Fajac A, Antoine M, Cadranel J, Voiriot G, Fartoukh M, Gibelin A
Am J Respir Crit Care Med 2022 Feb 1;205(3):357-359. doi: 10.1164/rccm.202104-0826IM. PMID: 34851783Free PMC Article
Typical presentation of pulmonary lepidic adenocarcinoma: a rare case report.
Azzeddine R, Rhorfi IA, Zegmout A, Souhi H, Elouazzani H, Abid A, Chahdi H, Tbouda M
Pan Afr Med J 2020;36:11. Epub 2020 May 11 doi: 10.11604/pamj.2020.36.11.22660. PMID: 32550974Free PMC Article
Approach to the Subsolid Nodule.
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632

Therapy

Lung transplantation for lung cancer: A systematic review of the literature.
Elsolh B, Bayat Z, Lyu D, Lin J, Wakeam E
J Heart Lung Transplant 2023 Oct;42(10):1425-1436. Epub 2023 May 28 doi: 10.1016/j.healun.2023.05.011. PMID: 37253398
Complete Lymphadenectomy for Clinical Stage I Lepidic Adenocarcinoma of the Lung: Is it justified?
Maurizi G, D'Andrilli A, Argento G, Ciccone AM, Ibrahim M, Andreetti C, Vanni C, Tierno SM, Venuta F, Rendina EA
Semin Thorac Cardiovasc Surg 2023 Summer;35(2):399-409. Epub 2022 Mar 8 doi: 10.1053/j.semtcvs.2021.11.020. PMID: 35272026
Middle lobe syndrome: An exceptional presentation of concomitant lepidic adenocarcinoma and bronchial anthracofibrosis.
Kunal S, Jain S, Shah A
Monaldi Arch Chest Dis 2017 Dec 19;87(3):864. doi: 10.4081/monaldi.2017.864. PMID: 29424200
Survival and risk factors for progression after resection of the dominant tumor in multifocal, lepidic-type pulmonary adenocarcinoma.
Gao RW, Berry MF, Kunder CA, Khuong AA, Wakelee H, Neal JW, Backhus LM, Shrager JB
J Thorac Cardiovasc Surg 2017 Dec;154(6):2092-2099.e2. Epub 2017 Aug 1 doi: 10.1016/j.jtcvs.2017.07.034. PMID: 28863952
Erlotinib versus carboplatin and paclitaxel in advanced lepidic adenocarcinoma: IFCT-0504.
Cadranel J, Gervais R, Merle P, Moro-Sibilot D, Westeel V, Bigay-Game L, Quoix E, Friard S, Barlesi F, Lethrosne C, Moreau L, Monnet I, Salaun M, Oliviero G, Souquet PJ, Antoine M, Langlais A, Morin F, Wislez M, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Eur Respir J 2015 Nov;46(5):1440-50. Epub 2015 Sep 17 doi: 10.1183/13993003.02358-2014. PMID: 26381515

Prognosis

Complete Lymphadenectomy for Clinical Stage I Lepidic Adenocarcinoma of the Lung: Is it justified?
Maurizi G, D'Andrilli A, Argento G, Ciccone AM, Ibrahim M, Andreetti C, Vanni C, Tierno SM, Venuta F, Rendina EA
Semin Thorac Cardiovasc Surg 2023 Summer;35(2):399-409. Epub 2022 Mar 8 doi: 10.1053/j.semtcvs.2021.11.020. PMID: 35272026
Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.
Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329Free PMC Article
Unusual presentation of lepidic adenocarcinoma in a healthy female.
Akhtar Z, Laageide L, Robles J, Winters C, Wall GC, Mallen J, Jawa Z
BMC Pulm Med 2022 May 16;22(1):197. doi: 10.1186/s12890-022-01969-1. PMID: 35578218Free PMC Article
Is chemotherapy rechallenge feasible in advanced-stage non-small-cell lung cancer?
Mignard X, Ruppert AM, Lavolé A, Vieira T, Rozensztajn N, Cadranel J, Wislez M
Bull Cancer 2019 Sep;106(9):725-733. Epub 2019 Jun 13 doi: 10.1016/j.bulcan.2019.04.010. PMID: 31202557
The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.
Cox ML, Yang CJ, Speicher PJ, Anderson KL, Fitch ZW, Gu L, Davis RP, Wang X, D'Amico TA, Hartwig MG, Harpole DH Jr, Berry MF
J Thorac Oncol 2017 Apr;12(4):689-696. Epub 2017 Jan 8 doi: 10.1016/j.jtho.2017.01.003. PMID: 28082103Free PMC Article

Clinical prediction guides

Feline pulmonary carcinoma: Gross, histological, metastatic, and immunohistochemical aspects.
Santos IR, Raiter J, Lamego ÉC, Bandinelli MB, Dal Pont TP, Siqueira KF, Almeida BA, Panzeira W, Sonne L, Driemeier D, Pavarini SP
Vet Pathol 2023 Jan;60(1):8-20. Epub 2022 Sep 13 doi: 10.1177/03009858221122517. PMID: 36112908
Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma.
Tang H, Qiao C, Wang Y, Bai C
Can Respir J 2022;2022:3676547. Epub 2022 Aug 31 doi: 10.1155/2022/3676547. PMID: 36091329Free PMC Article
Typical presentation of pulmonary lepidic adenocarcinoma: a rare case report.
Azzeddine R, Rhorfi IA, Zegmout A, Souhi H, Elouazzani H, Abid A, Chahdi H, Tbouda M
Pan Afr Med J 2020;36:11. Epub 2020 May 11 doi: 10.11604/pamj.2020.36.11.22660. PMID: 32550974Free PMC Article
Is chemotherapy rechallenge feasible in advanced-stage non-small-cell lung cancer?
Mignard X, Ruppert AM, Lavolé A, Vieira T, Rozensztajn N, Cadranel J, Wislez M
Bull Cancer 2019 Sep;106(9):725-733. Epub 2019 Jun 13 doi: 10.1016/j.bulcan.2019.04.010. PMID: 31202557
The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients.
Cox ML, Yang CJ, Speicher PJ, Anderson KL, Fitch ZW, Gu L, Davis RP, Wang X, D'Amico TA, Hartwig MG, Harpole DH Jr, Berry MF
J Thorac Oncol 2017 Apr;12(4):689-696. Epub 2017 Jan 8 doi: 10.1016/j.jtho.2017.01.003. PMID: 28082103Free PMC Article

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