U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FSH-Producing Pituitary Neuroendocrine Tumor

MedGen UID:
884640
•Concept ID:
C4055021
•
Neoplastic Process
Synonyms: Follicle Stimulating Hormone-Producing Gonadotroph Adenoma; FSH-Producing Pituitary Gland Adenoma

Definition

A pituitary neuroendocrine tumor that produces follicle-stimulating hormone (FSH). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFSH-Producing Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Molecular classification of pituitary adenomas: in search for criteria useful for high-throughput studies.
Żebracka-Gala J, Rudnik A, Hasse-Lazar K, Larysz D, Jarząb M, Krajewska J, Bażowski P, Jarząb B
Endokrynol Pol 2016;67(2):148-56. Epub 2016 Feb 17 doi: 10.5603/EP.a2016.0024. PMID: 26884293

Recent clinical studies

Etiology

Follicle stimulating hormone-secreting pituitary microadenoma with fluctuating levels of ovarian hyperstimulation.
Maruyama T, Masuda H, Uchida H, Nagashima T, Yoshimura Y
Obstet Gynecol 2005 May;105(5 Pt 2):1215-8. doi: 10.1097/01.AOG.0000141554.50747.16. PMID: 15863587
Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically nonfunctioning and somatotroph adenomas in vitro.
Klibanski A, Alexander JM, Bikkal HA, Hsu DW, Swearingen B, Zervas NT
J Clin Endocrinol Metab 1991 Dec;73(6):1248-55. doi: 10.1210/jcem-73-6-1248. PMID: 1720125

Diagnosis

A FSH-secreting pituitary adenoma discovered after ovarian hyperstimulation syndrome: a case report, illustrating pitfalls in the interpretation of serum FSH levels.
Yano K, Nakai G, Matsutani H, Yamada T, Ohmichi M, Yamamoto K, Osuga K
BMC Womens Health 2024 Dec 21;24(1):650. doi: 10.1186/s12905-024-03504-2. PMID: 39709410Free PMC Article
Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence.
Clemente M, Caracseghi F, Gussinyer M, Yeste D, Albisu M, Vázquez E, Ortega A, Carrascosa A
Horm Res Paediatr 2011;75(3):225-30. Epub 2010 Dec 23 doi: 10.1159/000322211. PMID: 21196695
A case report of FSH-producing nasal ectopic pituitary adenoma extending to the frontal cranial fossa.
Kitajiri S, Hosaka N, Tabuchi K, Hiraumi H, Nogaki H, Tatsumi S, Toki J, Ikehara S
Arch Otolaryngol Head Neck Surg 2000 Jun;126(6):782-4. doi: 10.1001/archotol.126.6.782. PMID: 10864117
An ACTH and FSH producing invasive pituitary adenoma with Crooke's hyalinization.
Kamijo K, Sato M, Saito T, Yachi A, Minase T, Noro H, Kawahara T
Pathol Res Pract 1991 Jun;187(5):637-41. doi: 10.1016/S0344-0338(11)80162-7. PMID: 1717963
Infarction of FSH-secreting pituitary adenoma.
Korsić M, Lelas-Bahun N, Surdonja P, Besenski N, Horvat S, Plavsić V
Acta Endocrinol (Copenh) 1984 Oct;107(2):149-54. doi: 10.1530/acta.0.1070149. PMID: 6437103

Therapy

Follicle-stimulating Hormone-secreting Pituitary Adenoma Accompanied by Painful Thyroiditis.
Ichijo M, Tsuchiya K, Kasai T, Inoshita N, Yoshimoto H, Yamada S, Kitamura K
Intern Med 2020 Feb 15;59(4):545-550. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.3667-19. PMID: 31611532Free PMC Article
Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.
Uchida S, Uchida H, Maruyama T, Kajitani T, Oda H, Miyazaki K, Kagami M, Yoshimura Y
PLoS One 2013;8(9):e75478. Epub 2013 Sep 13 doi: 10.1371/journal.pone.0075478. PMID: 24058690Free PMC Article
Pituitary adenoma: a DNA flow cytometric study of 192 clinicopathologically characterized tumors.
Gaffey TA Jr, Scheithauer BW, Leech RW, Blick K, Kovacs K, Horvath E, Weaver AL, Lloyd RV, Ebersold M, Laws ER Jr, DeBault LE
Clin Neuropathol 2005 Mar-Apr;24(2):56-63. PMID: 15803804
Reduction of follicle-stimulating hormone (FSH) secretion in FSH-producing pituitary adenoma by bromocriptine.
Berezin M, Olchovsky D, Pines A, Tadmor R, Lunenfeld B
J Clin Endocrinol Metab 1984 Dec;59(6):1220-3. doi: 10.1210/jcem-59-6-1220. PMID: 6436289
Glycoprotein hormone alpha-subunit secretion in patients with pituitary adenomas: influence of TRH, LRH and bromocriptine.
MacFarlane IA, Beardwell CG, Shalet SM, Ainslie G, Rankin E
Acta Endocrinol (Copenh) 1982 Apr;99(4):487-92. doi: 10.1530/acta.0.0990487. PMID: 6803489

Prognosis

Follicle-stimulating Hormone-secreting Pituitary Adenoma Accompanied by Painful Thyroiditis.
Ichijo M, Tsuchiya K, Kasai T, Inoshita N, Yoshimoto H, Yamada S, Kitamura K
Intern Med 2020 Feb 15;59(4):545-550. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.3667-19. PMID: 31611532Free PMC Article
Follicle stimulating hormone-secreting pituitary microadenoma with fluctuating levels of ovarian hyperstimulation.
Maruyama T, Masuda H, Uchida H, Nagashima T, Yoshimura Y
Obstet Gynecol 2005 May;105(5 Pt 2):1215-8. doi: 10.1097/01.AOG.0000141554.50747.16. PMID: 15863587
Pituitary adenoma: a DNA flow cytometric study of 192 clinicopathologically characterized tumors.
Gaffey TA Jr, Scheithauer BW, Leech RW, Blick K, Kovacs K, Horvath E, Weaver AL, Lloyd RV, Ebersold M, Laws ER Jr, DeBault LE
Clin Neuropathol 2005 Mar-Apr;24(2):56-63. PMID: 15803804
A case report of FSH-producing nasal ectopic pituitary adenoma extending to the frontal cranial fossa.
Kitajiri S, Hosaka N, Tabuchi K, Hiraumi H, Nogaki H, Tatsumi S, Toki J, Ikehara S
Arch Otolaryngol Head Neck Surg 2000 Jun;126(6):782-4. doi: 10.1001/archotol.126.6.782. PMID: 10864117
Infarction of FSH-secreting pituitary adenoma.
Korsić M, Lelas-Bahun N, Surdonja P, Besenski N, Horvat S, Plavsić V
Acta Endocrinol (Copenh) 1984 Oct;107(2):149-54. doi: 10.1530/acta.0.1070149. PMID: 6437103

Clinical prediction guides

A FSH-secreting pituitary adenoma discovered after ovarian hyperstimulation syndrome: a case report, illustrating pitfalls in the interpretation of serum FSH levels.
Yano K, Nakai G, Matsutani H, Yamada T, Ohmichi M, Yamamoto K, Osuga K
BMC Womens Health 2024 Dec 21;24(1):650. doi: 10.1186/s12905-024-03504-2. PMID: 39709410Free PMC Article
Molecular classification of pituitary adenomas: in search for criteria useful for high-throughput studies.
Żebracka-Gala J, Rudnik A, Hasse-Lazar K, Larysz D, Jarząb M, Krajewska J, Bażowski P, Jarząb B
Endokrynol Pol 2016;67(2):148-56. Epub 2016 Feb 17 doi: 10.5603/EP.a2016.0024. PMID: 26884293
Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence.
Clemente M, Caracseghi F, Gussinyer M, Yeste D, Albisu M, Vázquez E, Ortega A, Carrascosa A
Horm Res Paediatr 2011;75(3):225-30. Epub 2010 Dec 23 doi: 10.1159/000322211. PMID: 21196695
Immunoelectron microscopic demonstration of glycoprotein subunits in the FSH producing pituitary adenomas.
Osamura RY
Pathol Res Pract 1988 Sep;183(5):606-9. doi: 10.1016/s0344-0338(88)80021-9. PMID: 2467269
Infarction of FSH-secreting pituitary adenoma.
Korsić M, Lelas-Bahun N, Surdonja P, Besenski N, Horvat S, Plavsić V
Acta Endocrinol (Copenh) 1984 Oct;107(2):149-54. doi: 10.1530/acta.0.1070149. PMID: 6437103

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...