U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Infant Acute Lymphoblastic Leukemia

MedGen UID:
889772
•Concept ID:
C4054727
•
Neoplastic Process

Definition

An acute lymphoblastic leukemia that occurs in infancy. [from NCI]

Professional guidelines

PubMed

Combination of chemotherapy and all-trans retinoic acid for the treatment KMT2A-rearranged infant acute lymphoblastic leukemia. Results of the MLL-Baby trial.
Fechina L, Popov A, Tsaur G, Henze G, Shorikov E, Makarova O, Khlebnikova O, Zhukova Y, Arakaev O, Streneva O, Verzhbitskaya T, Riger T, Solodovnikov A, Lapotentova E, Aleinikova O, Myakova N, Boichenko E, Kondratchik K, Nikonova O, Shapochnik A, Goroshkova M, Ponomareva N, Novichkova G, Karachunskiy A, Roumiantsev A
Leukemia 2023 Nov;37(11):2276-2281. Epub 2023 Sep 23 doi: 10.1038/s41375-023-02034-4. PMID: 37741948
Recent progress in the treatment of infant acute lymphoblastic leukemia.
Tomizawa D
Pediatr Int 2015 Oct;57(5):811-9. doi: 10.1111/ped.12758. PMID: 26215843
Treatment outcome in infant acute lymphoblastic leukemia. Children Leukemia Cooperative Group--EORTC. European Organization for Research and Treatment of Cancer.
Ferster A, Benoit Y, Francotte N, Dresse MF, Uyttebroeck A, Plouvier E, Thyss A, Lutz P, Marguerite G, Behar C, Mazingue F, Boutard P, Millot F, Rialland X, Mechinaud F, Norton L, Robert A, Otten J, Vilmer E, Philippe N, Waterkeyn C, Suciu S
Blood 2000 Apr 15;95(8):2729-31. PMID: 10809540

Recent clinical studies

Etiology

Infant Acute Lymphoblastic Leukemia-New Therapeutic Opportunities.
Kulczycka M, Derlatka K, Tasior J, Sygacz M, Lejman M, Zawitkowska J
Int J Mol Sci 2024 Mar 27;25(7) doi: 10.3390/ijms25073721. PMID: 38612531Free PMC Article
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study.
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

Diagnosis

Infant Acute Lymphoblastic Leukemia-New Therapeutic Opportunities.
Kulczycka M, Derlatka K, Tasior J, Sygacz M, Lejman M, Zawitkowska J
Int J Mol Sci 2024 Mar 27;25(7) doi: 10.3390/ijms25073721. PMID: 38612531Free PMC Article
Immunological assessment of a patient with infant acute lymphoblastic leukemia.
Takagi M, Tomoyasu C, Yamanaka J, Hamabata T, Isoda T, Miyamura T, Imai K
Pediatr Int 2024 Jan-Dec;66(1):e15738. doi: 10.1111/ped.15738. PMID: 38409899
Updates in infant acute lymphoblastic leukemia and the potential for targeted therapy.
Kotecha RS
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):611-617. doi: 10.1182/hematology.2022000359. PMID: 36485124Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

Therapy

Updates in infant acute lymphoblastic leukemia and the potential for targeted therapy.
Kotecha RS
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):611-617. doi: 10.1182/hematology.2022000359. PMID: 36485124Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia.
Wander P, Cheung LC, Pinhanҫos SS, Jones L, Kerstjens M, Arentsen-Peters STCJM, Singh S, Chua GA, Castro PG, Schneider P, Dolman MEM, Koopmans B, Molenaar JJ, Pieters R, Zwaan CM, Kotecha RS, Stam RW
Leukemia 2020 Nov;34(11):2898-2902. Epub 2020 Jun 2 doi: 10.1038/s41375-020-0895-9. PMID: 32488115
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study.
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

Prognosis

How I treat infant acute lymphoblastic leukemia.
Bartram J, Ancliff P, Vora A
Blood 2025 Jan 2;145(1):35-42. doi: 10.1182/blood.2023023154. PMID: 38905593
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study.
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Bilateral parotid gland enlargement and palpable nephromegaly in infant acute lymphoblastic leukemia: case report and review of the literature.
Saha A, Dandekar S, Milla S, Roman E, Bhatla T
J Pediatr Hematol Oncol 2014 Apr;36(3):246-8. doi: 10.1097/MPH.0000000000000076. PMID: 24309613

Clinical prediction guides

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Infant lymphoblastic leukemia: a single centers 10 year experience.
Yaman-Bajin İ, Aytaç S, Kuşkonmaz B, Uçkan-Çetinkaya D, Ünal Ş, Gümrük F, Çetin M
Turk J Pediatr 2019;61(3):325-329. doi: 10.24953/turkjped.2019.03.002. PMID: 31916708
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Decreased induction morbidity and mortality following modification to induction therapy in infants with acute lymphoblastic leukemia enrolled on AALL0631: a report from the Children's Oncology Group.
Salzer WL, Jones TL, Devidas M, Dreyer ZE, Gore L, Winick NJ, Sung L, Raetz E, Loh ML, Wang CY, De Lorenzo P, Valsecchi MG, Pieters R, Carroll WL, Hunger SP, Hilden JM, Brown P
Pediatr Blood Cancer 2015 Mar;62(3):414-8. Epub 2014 Nov 18 doi: 10.1002/pbc.25311. PMID: 25407157Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...