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Abnormal circulating follicle-stimulating hormone concentration

MedGen UID:
892827
Concept ID:
C4072891
Finding
Synonym: Abnormal circulating follicle-stimulating hormone level
 
HPO: HP:0030346

Definition

An anomaly of the circulating level of follicle-stimulating hormone (FSH). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating follicle-stimulating hormone concentration

Conditions with this feature

Spermatogenic failure 2
MedGen UID:
400056
Concept ID:
C1862459
Finding
Spermatogenic failure-2 (SPGF2) is characterized by male infertility due to azoospermia (Tang et al., 2020; Akbari et al., 2021). For a discussion of phenotypic and genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).
Spermatogenic failure 15
MedGen UID:
934746
Concept ID:
C4310779
Disease or Syndrome
Any azoospermia in which the cause of the disease is a mutation in the SYCE1 gene.
Spermatogenic failure 90
MedGen UID:
1853928
Concept ID:
C5935587
Disease or Syndrome
Spermatogenic failure-90 (SPGF90) is characterized by male infertility due to asthenozoospermia, in which progressive motility of sperm is markedly reduced. This form of infertility can be rescued by intracytoplasmic sperm injection (ICSI) (Liu et al., 2023). For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).

Professional guidelines

PubMed

Mendoza-Morfin F, Rodríguez-López M, Oliveros-Rodríguez A, Altamirano-Bustamante P, Navarrete-López R, Gutiérrez-Pérez H, Oseguera-Valladares R
Arch Invest Med (Mex) 1980;11(2):239-47. PMID: 6775612

Recent clinical studies

Etiology

Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441
Azziz R, Bradley EL Jr, Potter HD, Boots LR
Am J Obstet Gynecol 1993 Mar;168(3 Pt 1):889-95. doi: 10.1016/s0002-9378(12)90840-6. PMID: 8456898
Vihko RK, Apter DL
Cancer Surv 1986;5(3):561-71. PMID: 3555783

Diagnosis

Mariani M, Fintini D, Cirillo G, Palumbo S, Del Giudice EM, Bocchini S, Manco M, Cappa M, Grandone A
J Endocrinol Invest 2022 Nov;45(11):2165-2170. Epub 2022 Jul 19 doi: 10.1007/s40618-022-01860-0. PMID: 35854182
Seyam E, Hefzy E
Gynecol Endocrinol 2018 Jun;34(6):481-488. Epub 2017 Dec 19 doi: 10.1080/09513590.2017.1416462. PMID: 29254383
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567
Vihko RK, Apter DL
Cancer Surv 1986;5(3):561-71. PMID: 3555783

Therapy

Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Soliman AT, elZalabany MM, Ragab M, Abdel Fattah M, Hassab H, Rogol AD, Ansari BM
J Trop Pediatr 2000 Apr;46(2):79-85. doi: 10.1093/tropej/46.2.79. PMID: 10822933
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441

Prognosis

Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Arafah BM, Harrington JF, Madhoun ZT, Selman WR
J Clin Endocrinol Metab 1990 Aug;71(2):323-8. doi: 10.1210/jcem-71-2-323. PMID: 2166068

Clinical prediction guides

Mariani M, Fintini D, Cirillo G, Palumbo S, Del Giudice EM, Bocchini S, Manco M, Cappa M, Grandone A
J Endocrinol Invest 2022 Nov;45(11):2165-2170. Epub 2022 Jul 19 doi: 10.1007/s40618-022-01860-0. PMID: 35854182
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Santoro N, Isaac B, Neal-Perry G, Adel T, Weingart L, Nussbaum A, Thakur S, Jinnai H, Khosla N, Barad D
J Clin Endocrinol Metab 2003 Nov;88(11):5502-9. doi: 10.1210/jc.2002-021839. PMID: 14602797
Pache TD, Hop WC, de Jong FH, Leerentveld RA, van Geldorp H, Van de Kamp TM, Gooren LJ, Fauser BC
Clin Endocrinol (Oxf) 1992 Jun;36(6):565-71. doi: 10.1111/j.1365-2265.1992.tb02266.x. PMID: 1424181
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567

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