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Abnormal fundus fluorescein angiography

MedGen UID:
892879
Concept ID:
C4073074
Finding
HPO: HP:0030604

Definition

An abnormality observed by retinal fluorescein angiography, which involves the intravenous injection of fluorescein dye followed by fluorescent imaging of the fundus immediately after injection and for up to ten minutes thereafter. It can be used to study various retinal abnormalities including especially anomalies of the choroidal and retinal circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal fundus fluorescein angiography

Conditions with this feature

Occult macular dystrophy
MedGen UID:
462183
Concept ID:
C3150833
Disease or Syndrome
Occult macular dystrophy (OCMD) is characterized by progressive decline of visual acuity in both eyes, associated with a normal fundus and normal fluorescein angiography. Patients have normal full-field electroretinograms (ERGs) but severely reduced focal macular ERGs, as recorded by conventional techniques using small stimuli under background illumination. OCMD patients are believed to have localized retinal dysfunction distal to the ganglion cells in the central retina (summary by Piao et al., 2000).

Professional guidelines

PubMed

Das S, Kuht HJ, De Silva I, Deol SS, Osman L, Burns J, Sarvananthan N, Sarodia U, Kapoor B, Islam T, Sampath R, Poyser A, Konidaris V, Anzidei R, Proudlock FA, Thomas MG
Eye (Lond) 2023 Feb;37(2):274-279. Epub 2022 Jan 12 doi: 10.1038/s41433-021-01926-y. PMID: 35022568Free PMC Article
Sen M, Shields CL, Honavar SG, Shields JA
Indian J Ophthalmol 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19. PMID: 31124484Free PMC Article
Anantharaman G, Sheth J, Bhende M, Narayanan R, Natarajan S, Rajendran A, Manayath G, Sen P, Biswas R, Banker A, Gupta C
Indian J Ophthalmol 2018 Jul;66(7):896-908. doi: 10.4103/ijo.IJO_1136_17. PMID: 29941728Free PMC Article

Recent clinical studies

Etiology

Birtel J, von Landenberg C, Gliem M, Gliem C, Reimann J, Kunz WS, Herrmann P, Betz C, Caswell R, Nesbitt V, Kornblum C, Charbel Issa P
Ophthalmol Retina 2022 Jan;6(1):65-79. Epub 2021 Jul 10 doi: 10.1016/j.oret.2021.02.017. PMID: 34257060
Rishi P, Singh N, Rishi E
Indian J Ophthalmol 2019 Jun;67(6):940-942. doi: 10.4103/ijo.IJO_760_18. PMID: 31124521Free PMC Article
Le Rouic JF, Brejtfus-Thomas J
Ophthalmic Surg Lasers Imaging Retina 2018 Dec 1;49(12):e284-e286. doi: 10.3928/23258160-20181203-20. PMID: 30566715
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590Free PMC Article
Dhir SP, Gupta A, Jain IS
Br J Ophthalmol 1981 Jan;65(1):42-5. doi: 10.1136/bjo.65.1.42. PMID: 7448156Free PMC Article

Diagnosis

Ruben M, Yaghy A, Park CH, Shields CL
J Pediatr Ophthalmol Strabismus 2020 Oct 20;57:e82-e85. doi: 10.3928/01913913-20200818-01. PMID: 33090232
Sen M, Shields CL, Honavar SG, Shields JA
Indian J Ophthalmol 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19. PMID: 31124484Free PMC Article
Cheung CMG, Lee WK, Koizumi H, Dansingani K, Lai TYY, Freund KB
Eye (Lond) 2019 Jan;33(1):14-33. Epub 2018 Jul 11 doi: 10.1038/s41433-018-0158-4. PMID: 29995841Free PMC Article
Soubrane G
Dev Ophthalmol 2017;58:202-219. Epub 2017 Mar 28 doi: 10.1159/000455282. PMID: 28351049
Dhir SP, Gupta A, Jain IS
Br J Ophthalmol 1981 Jan;65(1):42-5. doi: 10.1136/bjo.65.1.42. PMID: 7448156Free PMC Article

Therapy

Jiang T, Gu J, Liu S, Chang Q
BMC Ophthalmol 2022 Sep 20;22(1):375. doi: 10.1186/s12886-022-02604-7. PMID: 36127675Free PMC Article
Faure C, Salamé N, Cahuzac A, Mauget-Faÿsse M, Scemama C
Retin Cases Brief Rep 2022 May 1;16(3):329-332. Epub 2020 Jan 16 doi: 10.1097/ICB.0000000000000969. PMID: 31971924
Marciano S, Mutolo MG, Siracusano M, Moavero R, Curatolo P, Emberti Gialloreti L
Ophthalmol Retina 2018 Mar;2(3):257-260. Epub 2017 Oct 12 doi: 10.1016/j.oret.2017.08.005. PMID: 31047596
Spaide RF, Leys A, Herrmann-Delemazure B, Stalmans P, Tittl M, Yannuzzi LA, Burke KM, Fisher YL, Freund KB, Guyer DR, Slakter JS, Sorenson JA
Ophthalmology 1999 Dec;106(12):2254-60. doi: 10.1016/S0161-6420(99)90524-9. PMID: 10599654
Millay RH, Klein ML, Illingworth DR
Ophthalmology 1988 Jul;95(7):930-6. doi: 10.1016/s0161-6420(88)33073-3. PMID: 3174043

Prognosis

Ruben M, Yaghy A, Park CH, Shields CL
J Pediatr Ophthalmol Strabismus 2020 Oct 20;57:e82-e85. doi: 10.3928/01913913-20200818-01. PMID: 33090232
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590Free PMC Article
Vander JF
Curr Opin Ophthalmol 2000 Jun;11(3):159-65. doi: 10.1097/00055735-200006000-00001. PMID: 10977220
Blodi CF, Stone EM
Ophthalmic Paediatr Genet 1990 Mar;11(1):49-59. PMID: 2190134
Dhir SP, Gupta A, Jain IS
Br J Ophthalmol 1981 Jan;65(1):42-5. doi: 10.1136/bjo.65.1.42. PMID: 7448156Free PMC Article

Clinical prediction guides

Le Rouic JF, Brejtfus-Thomas J
Ophthalmic Surg Lasers Imaging Retina 2018 Dec 1;49(12):e284-e286. doi: 10.3928/23258160-20181203-20. PMID: 30566715
Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590Free PMC Article
Monnet D, Brézin AP
Curr Opin Ophthalmol 2006 Dec;17(6):545-50. doi: 10.1097/ICU.0b013e3280109479. PMID: 17065923
Pian D, Ferrucci S, Anderson SF, Wu C
Optom Vis Sci 2003 Aug;80(8):556-63. doi: 10.1097/00006324-200308000-00008. PMID: 12917574

Recent systematic reviews

Daniels AB, Chang EY, Chew EY, Gombos DS, Gorin MB, Shields CL, Wiley HE
Ophthalmology 2024 May;131(5):622-633. Epub 2023 Dec 12 doi: 10.1016/j.ophtha.2023.12.014. PMID: 38092079
Biffi E, Turple Z, Chung J, Biffi A
PLoS One 2022;17(4):e0266974. Epub 2022 Apr 14 doi: 10.1371/journal.pone.0266974. PMID: 35421194Free PMC Article
Hou X, Guo Y, Liu J, Li S, Fan W, Lin M, Rokohl AC, Heindl LM
Curr Eye Res 2021 Jul;46(7):913-918. Epub 2021 Jan 22 doi: 10.1080/02713683.2020.1853779. PMID: 33478254
Xu A, Chen C
Int Ophthalmol 2021 Feb;41(2):727-741. Epub 2020 Oct 11 doi: 10.1007/s10792-020-01609-9. PMID: 33040254
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279

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