U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal ocular adnexa morphology

MedGen UID:
893067
•Concept ID:
C4073120
•
Anatomical Abnormality
Synonym: Abnormal morphology of the ocular adnexa
 
HPO: HP:0030669

Definition

A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal ocular adnexa morphology

Professional guidelines

PubMed

Management of the marginal zone lymphomas.
Vannata B, Stathis A, Zucca E
Cancer Treat Res 2015;165:227-49. doi: 10.1007/978-3-319-13150-4_9. PMID: 25655612

Recent clinical studies

Etiology

Eye and ocular adnexa manifestations of MED12-related disorders.
Shah A, Bapna M, Al-Saif H, Li R, Couser NL
Ophthalmic Genet 2022 Feb;43(1):126-129. Epub 2021 Oct 20 doi: 10.1080/13816810.2021.1989601. PMID: 34670449
Prevalence of Ocular Pathology on Initial Screening and Incidence of New Findings on Follow-up Examinations in Children With Trisomy 21.
Umfress AC, Hair CD, Donahue SP
Am J Ophthalmol 2019 Nov;207:373-377. Epub 2019 Jun 17 doi: 10.1016/j.ajo.2019.06.006. PMID: 31220432
Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study.
Singalavanija T, Ausayakhun S, Tangmonkongvoragul C
PLoS One 2018;13(2):e0193161. Epub 2018 Feb 21 doi: 10.1371/journal.pone.0193161. PMID: 29466424Free PMC Article
Ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder.
Kubota T, Moritani S, Katayama M, Terasaki H
Arch Ophthalmol 2010 May;128(5):577-84. doi: 10.1001/archophthalmol.2010.45. PMID: 20457978
Ocular autonomic nerve function in Lambert-Eaton myasthenic syndrome.
Clark CV, Newsom-Davis J, Sanders MD
Eye (Lond) 1990;4 ( Pt 3):473-81. doi: 10.1038/eye.1990.61. PMID: 2209912

Diagnosis

Subepidermal Calcinosis in the Ocular Adnexa: A Systematic Review.
Khine KT, Shi DS, Bernhisel A, Gertsch KR, Mamalis N, Patel BCK, Dutton JJ
Ophthalmic Plast Reconstr Surg 2018 Mar/Apr;34(2):101-105. doi: 10.1097/IOP.0000000000000936. PMID: 28430707
Vellus Hair Cyst of the Orbit.
Choi R, MacLean KD, Davidson HC, Patel BCK
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S89-S91. doi: 10.1097/IOP.0000000000000469. PMID: 25856335
Management of the marginal zone lymphomas.
Vannata B, Stathis A, Zucca E
Cancer Treat Res 2015;165:227-49. doi: 10.1007/978-3-319-13150-4_9. PMID: 25655612
Congenital malformations of the eye and orbit.
Guercio JR, Martyn LJ
Otolaryngol Clin North Am 2007 Feb;40(1):113-40, vii. doi: 10.1016/j.otc.2006.11.013. PMID: 17346564
Lymphoproliferative disorders of the ocular adnexa.
Cockerham GC, Jakobiec FA
Int Ophthalmol Clin 1997 Fall;37(4):39-59. doi: 10.1097/00004397-199703740-00005. PMID: 9429931

Therapy

Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study.
Singalavanija T, Ausayakhun S, Tangmonkongvoragul C
PLoS One 2018;13(2):e0193161. Epub 2018 Feb 21 doi: 10.1371/journal.pone.0193161. PMID: 29466424Free PMC Article
Management of the marginal zone lymphomas.
Vannata B, Stathis A, Zucca E
Cancer Treat Res 2015;165:227-49. doi: 10.1007/978-3-319-13150-4_9. PMID: 25655612
Prevalence of biomicroscopic findings in the anterior segment and ocular adnexa among schoolchildren in Natal/Brazil.
Garcia CA, Pinheiro FI, Montenegro DA, Gomes AH, Oréfice F
Arq Bras Oftalmol 2005 Mar-Apr;68(2):167-70. Epub 2005 May 18 doi: 10.1590/s0004-27492005000200003. PMID: 15905935
Ocular manifestations of keratitis-ichthyosis-deafness (KID) syndrome.
Messmer EM, Kenyon KR, Rittinger O, Janecke AR, Kampik A
Ophthalmology 2005 Feb;112(2):e1-6. doi: 10.1016/j.ophtha.2004.07.034. PMID: 15691545
Optic nerve hypoplasia: comparative effects in children and rats exposed to alcohol during pregnancy.
Strömland K, Pinazo-Durán MD
Teratology 1994 Aug;50(2):100-11. doi: 10.1002/tera.1420500204. PMID: 7801297

Prognosis

Distichiasis: An update on etiology, treatment and outcomes.
Singh S
Indian J Ophthalmol 2022 Apr;70(4):1100-1106. doi: 10.4103/ijo.IJO_1141_21. PMID: 35325995Free PMC Article
Prevalence of Ocular Pathology on Initial Screening and Incidence of New Findings on Follow-up Examinations in Children With Trisomy 21.
Umfress AC, Hair CD, Donahue SP
Am J Ophthalmol 2019 Nov;207:373-377. Epub 2019 Jun 17 doi: 10.1016/j.ajo.2019.06.006. PMID: 31220432
Ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder.
Kubota T, Moritani S, Katayama M, Terasaki H
Arch Ophthalmol 2010 May;128(5):577-84. doi: 10.1001/archophthalmol.2010.45. PMID: 20457978
Low-dose radiotherapy for lymphoid lesions of the orbit and ocular adnexa.
Kennerdell JS, Flores NE, Hartsock RJ
Ophthalmic Plast Reconstr Surg 1999 Mar;15(2):129-33. doi: 10.1097/00002341-199903000-00012. PMID: 10189642
Lymphoproliferative disorders of the ocular adnexa.
Cockerham GC, Jakobiec FA
Int Ophthalmol Clin 1997 Fall;37(4):39-59. doi: 10.1097/00004397-199703740-00005. PMID: 9429931

Clinical prediction guides

Corneal epitheliopathy in congenital methemoglobinemia.
Chaurasia S, Ramappa M, Bhargava A
Cornea 2014 Apr;33(4):422-4. doi: 10.1097/ICO.0000000000000076. PMID: 24503601
Orbital syndromes.
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868
Ocular manifestations of keratitis-ichthyosis-deafness (KID) syndrome.
Messmer EM, Kenyon KR, Rittinger O, Janecke AR, Kampik A
Ophthalmology 2005 Feb;112(2):e1-6. doi: 10.1016/j.ophtha.2004.07.034. PMID: 15691545
Histopathological abnormalities in ocular blood vessels of CADASIL patients.
Haritoglou C, Hoops JP, Stefani FH, Mehraein P, Kampik A, Dichgans M
Am J Ophthalmol 2004 Aug;138(2):302-5. doi: 10.1016/j.ajo.2004.02.073. PMID: 15289148
Low-dose radiotherapy for lymphoid lesions of the orbit and ocular adnexa.
Kennerdell JS, Flores NE, Hartsock RJ
Ophthalmic Plast Reconstr Surg 1999 Mar;15(2):129-33. doi: 10.1097/00002341-199903000-00012. PMID: 10189642

Recent systematic reviews

Eye and ocular adnexa manifestations of MED12-related disorders.
Shah A, Bapna M, Al-Saif H, Li R, Couser NL
Ophthalmic Genet 2022 Feb;43(1):126-129. Epub 2021 Oct 20 doi: 10.1080/13816810.2021.1989601. PMID: 34670449
Ophthalmic manifestations in Kabuki (make-up) syndrome: A single-center pediatric cohort and systematic review of the literature.
Merdler-Rabinowicz R, Prat D, Pode-Shakked B, Abel G, Chorin O, Somech R, Raas-Rothschild A
Eur J Med Genet 2021 Jun;64(6):104210. Epub 2021 Mar 30 doi: 10.1016/j.ejmg.2021.104210. PMID: 33794347
Subepidermal Calcinosis in the Ocular Adnexa: A Systematic Review.
Khine KT, Shi DS, Bernhisel A, Gertsch KR, Mamalis N, Patel BCK, Dutton JJ
Ophthalmic Plast Reconstr Surg 2018 Mar/Apr;34(2):101-105. doi: 10.1097/IOP.0000000000000936. PMID: 28430707

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...