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Abnormal DLCO

MedGen UID:
893139
•Concept ID:
C4073173
•
Finding
Synonyms: Abnormal diffusing capacity; Abnormal TLCO; Abnormal transfer factor of the lung for carbon monoxide
 
HPO: HP:0045049

Definition

An abnormal amount of oxygen passes into the blood from the lungs and/or an abnormal amount of carbon dioxide passes from the blood into the lungs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal DLCO

Professional guidelines

PubMed

Long-term pulmonary sequelae after treatment of childhood Hodgkin's disease.
Bossi G, Cerveri I, Volpini E, Corsico A, Baio A, Corbella F, Klersy C, Arico M
Ann Oncol 1997;8 Suppl 1:19-24. PMID: 9187424

Recent clinical studies

Etiology

Female Sex Affects Respiratory Function and Exercise Ability in Patients Recovered from COVID-19 Pneumonia.
Spicuzza L, Campisi R, Alia S, Prestifilippo S, Giuffrida ML, Angileri L, Ciancio N, Vancheri C
J Womens Health (Larchmt) 2023 Jan;32(1):18-23. Epub 2022 Nov 25 doi: 10.1089/jwh.2022.0104. PMID: 36450116
Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L
AIDS 2021 Jun 1;35(7):1031-1040. doi: 10.1097/QAD.0000000000002846. PMID: 33635847Free PMC Article
Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma.
Agrusa JE, Kothari VD, Brown AL, Masand PM, Lewis GD, Teh BS, Paulino AC, Silva-Carmona MD, Melicoff E, Allen CE, Gramatges MM
Leuk Lymphoma 2020 Oct;61(10):2419-2427. Epub 2020 Jun 10 doi: 10.1080/10428194.2020.1772478. PMID: 32519904Free PMC Article
Approach to the patient with pulmonary disease.
Vander Els NJ, Stover DE
Clin Chest Med 1996 Dec;17(4):767-85. doi: 10.1016/s0272-5231(05)70346-4. PMID: 9016378
Pulmonary toxicity in patients with non-Hodgkin's lymphoma treated with bleomycin-containing combination chemotherapy.
Ngan HY, Liang RH, Lam WK, Chan TK
Cancer Chemother Pharmacol 1993;32(5):407-9. doi: 10.1007/BF00735929. PMID: 7687934

Diagnosis

Development and evaluation of a computerized algorithm for the interpretation of pulmonary function tests.
Huang YT, Henriquez L, Chen H, Henriquez C
PLoS One 2024;19(1):e0297519. Epub 2024 Jan 29 doi: 10.1371/journal.pone.0297519. PMID: 38285673Free PMC Article
Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L
AIDS 2021 Jun 1;35(7):1031-1040. doi: 10.1097/QAD.0000000000002846. PMID: 33635847Free PMC Article
Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma.
Agrusa JE, Kothari VD, Brown AL, Masand PM, Lewis GD, Teh BS, Paulino AC, Silva-Carmona MD, Melicoff E, Allen CE, Gramatges MM
Leuk Lymphoma 2020 Oct;61(10):2419-2427. Epub 2020 Jun 10 doi: 10.1080/10428194.2020.1772478. PMID: 32519904Free PMC Article
Approach to the patient with pulmonary disease.
Vander Els NJ, Stover DE
Clin Chest Med 1996 Dec;17(4):767-85. doi: 10.1016/s0272-5231(05)70346-4. PMID: 9016378
Pulmonary function tests.
Stover DE, Meduri GU
Clin Chest Med 1988 Sep;9(3):473-9. PMID: 3044683

Therapy

Long-term Pulmonary Outcomes in Pediatric Survivors of High-risk Neuroblastoma.
Stone A, Novetsky Friedman D, Worgall S, Kushner BH, Wolden S, Modak S, LaQuaglia MP, Wu X, Cheung NK, Sklar CA
J Pediatr Hematol Oncol 2017 Oct;39(7):547-554. doi: 10.1097/MPH.0000000000000883. PMID: 28692550Free PMC Article
Lung function abnormalities among service members returning from Iraq or Afghanistan with respiratory complaints.
Holley AB, Sobieszczyk M, Perkins M, Cohee BM, Costantoth CB, Mabe DL, Liotta R, Abraham JH, Holley PR, Sherner J
Respir Med 2016 Sep;118:84-87. Epub 2016 Jul 25 doi: 10.1016/j.rmed.2016.07.014. PMID: 27578475
Long-term pulmonary sequelae after treatment of childhood Hodgkin's disease.
Bossi G, Cerveri I, Volpini E, Corsico A, Baio A, Corbella F, Klersy C, Arico M
Ann Oncol 1997;8 Suppl 1:19-24. PMID: 9187424
Pulmonary toxicity in patients with non-Hodgkin's lymphoma treated with bleomycin-containing combination chemotherapy.
Ngan HY, Liang RH, Lam WK, Chan TK
Cancer Chemother Pharmacol 1993;32(5):407-9. doi: 10.1007/BF00735929. PMID: 7687934
Pediatric Hodgkin's disease: pulmonary, cardiac, and thyroid function following combined modality therapy.
Mefferd JM, Donaldson SS, Link MP
Int J Radiat Oncol Biol Phys 1989 Mar;16(3):679-85. doi: 10.1016/0360-3016(89)90485-9. PMID: 2466027

Prognosis

Female Sex Affects Respiratory Function and Exercise Ability in Patients Recovered from COVID-19 Pneumonia.
Spicuzza L, Campisi R, Alia S, Prestifilippo S, Giuffrida ML, Angileri L, Ciancio N, Vancheri C
J Womens Health (Larchmt) 2023 Jan;32(1):18-23. Epub 2022 Nov 25 doi: 10.1089/jwh.2022.0104. PMID: 36450116
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors.
Zhang S, Bai W, Yue J, Qin L, Zhang C, Xu S, Liu X, Ni W, Xie M
Sci Rep 2021 Jul 5;11(1):13854. doi: 10.1038/s41598-021-93191-y. PMID: 34226597Free PMC Article
Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L
AIDS 2021 Jun 1;35(7):1031-1040. doi: 10.1097/QAD.0000000000002846. PMID: 33635847Free PMC Article
Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma.
Agrusa JE, Kothari VD, Brown AL, Masand PM, Lewis GD, Teh BS, Paulino AC, Silva-Carmona MD, Melicoff E, Allen CE, Gramatges MM
Leuk Lymphoma 2020 Oct;61(10):2419-2427. Epub 2020 Jun 10 doi: 10.1080/10428194.2020.1772478. PMID: 32519904Free PMC Article
Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era.
Morris A, Gingo MR, George MP, Lucht L, Kessinger C, Singh V, Hillenbrand M, Busch M, McMahon D, Norris KA, Champion HC, Gladwin MT, Zhang Y, Steele C, Sciurba FC
AIDS 2012 Mar 27;26(6):731-40. doi: 10.1097/QAD.0b013e32835099ae. PMID: 22210636Free PMC Article

Clinical prediction guides

Female Sex Affects Respiratory Function and Exercise Ability in Patients Recovered from COVID-19 Pneumonia.
Spicuzza L, Campisi R, Alia S, Prestifilippo S, Giuffrida ML, Angileri L, Ciancio N, Vancheri C
J Womens Health (Larchmt) 2023 Jan;32(1):18-23. Epub 2022 Nov 25 doi: 10.1089/jwh.2022.0104. PMID: 36450116
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors.
Zhang S, Bai W, Yue J, Qin L, Zhang C, Xu S, Liu X, Ni W, Xie M
Sci Rep 2021 Jul 5;11(1):13854. doi: 10.1038/s41598-021-93191-y. PMID: 34226597Free PMC Article
Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L
AIDS 2021 Jun 1;35(7):1031-1040. doi: 10.1097/QAD.0000000000002846. PMID: 33635847Free PMC Article
Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma.
Agrusa JE, Kothari VD, Brown AL, Masand PM, Lewis GD, Teh BS, Paulino AC, Silva-Carmona MD, Melicoff E, Allen CE, Gramatges MM
Leuk Lymphoma 2020 Oct;61(10):2419-2427. Epub 2020 Jun 10 doi: 10.1080/10428194.2020.1772478. PMID: 32519904Free PMC Article
Clinical Features of Smokers With Radiological Emphysema But Without Airway Limitation.
Alcaide AB, Sanchez-Salcedo P, Bastarrika G, Campo A, Berto J, Ocon MD, Fernandez-Montero A, Celli BR, Zulueta JJ, de-Torres JP
Chest 2017 Feb;151(2):358-365. Epub 2016 Nov 3 doi: 10.1016/j.chest.2016.10.044. PMID: 27818328

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