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Latent autoimmune diabetes in adults

MedGen UID:
895261
•Concept ID:
C1739108
•
Disease or Syndrome
Synonyms: Diabetes Mellitus Type 1.5; Diabetes, Type 1.5; LADA, Latent Autoimmune Diabetes in Adults; Latent Autoimmune Diabetes in Adults; Latent Autoimmune Diabetes of Adults; Type 1.5 Diabetes; Type 1.5 Diabetes Mellitus
 
Monarch Initiative: MONDO:0850306

Definition

A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable ß-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLatent autoimmune diabetes in adults

Professional guidelines

PubMed

Atypical Diabetes and Management Considerations.
Patil SP
Prim Care 2022 Jun;49(2):225-237. Epub 2022 Apr 22 doi: 10.1016/j.pop.2021.11.003. PMID: 35595479
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.
Buzzetti R, Tuomi T, Mauricio D, Pietropaolo M, Zhou Z, Pozzilli P, Leslie RD
Diabetes 2020 Oct;69(10):2037-2047. Epub 2020 Aug 26 doi: 10.2337/dbi20-0017. PMID: 32847960Free PMC Article
Treatment of Latent Autoimmune Diabetes in Adults: What is Best?
Hals IK
Curr Diabetes Rev 2019;15(3):188-193. doi: 10.2174/1573399814666180716144429. PMID: 30009709

Recent clinical studies

Etiology

All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults.
Wei Y, Herzog K, Ahlqvist E, Andersson T, Nyström T, Zhan Y, Tuomi T, Carlsson S
Diabetes Care 2023 Oct 1;46(10):1857-1865. doi: 10.2337/dc23-0739. PMID: 37635682Free PMC Article
Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Zhan Y, Carlsson S
Lancet Glob Health 2023 Mar;11 Suppl 1:S1. doi: 10.1016/S2214-109X(23)00086-4. PMID: 36866468
Editorial: Latent Autoimmune Diabetes in Adults (LADA).
Leslie RD
Front Endocrinol (Lausanne) 2022;13:1002776. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.1002776. PMID: 36105403Free PMC Article
Latent Autoimmune Diabetes in Adults and Metabolic Syndrome-A Mini Review.
Pan N, Yang S, Niu X
Front Endocrinol (Lausanne) 2022;13:913373. Epub 2022 Jun 28 doi: 10.3389/fendo.2022.913373. PMID: 35837301Free PMC Article
Latent autoimmune diabetes in adults (LADA).
Naik RG, Palmer JP
Rev Endocr Metab Disord 2003 Sep;4(3):233-41. doi: 10.1023/a:1025148211587. PMID: 14501174

Diagnosis

Anti-Islet Autoantibodies in Type 1 Diabetes.
Kawasaki E
Int J Mol Sci 2023 Jun 11;24(12) doi: 10.3390/ijms241210012. PMID: 37373160Free PMC Article
Adult-onset autoimmune diabetes.
Buzzetti R, Maddaloni E, Gaglia J, Leslie RD, Wong FS, Boehm BO
Nat Rev Dis Primers 2022 Sep 22;8(1):63. doi: 10.1038/s41572-022-00390-6. PMID: 36138034
The clinical consequences of heterogeneity within and between different diabetes types.
Redondo MJ, Hagopian WA, Oram R, Steck AK, Vehik K, Weedon M, Balasubramanyam A, Dabelea D
Diabetologia 2020 Oct;63(10):2040-2048. Epub 2020 Sep 7 doi: 10.1007/s00125-020-05211-7. PMID: 32894314Free PMC Article
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.
Buzzetti R, Tuomi T, Mauricio D, Pietropaolo M, Zhou Z, Pozzilli P, Leslie RD
Diabetes 2020 Oct;69(10):2037-2047. Epub 2020 Aug 26 doi: 10.2337/dbi20-0017. PMID: 32847960Free PMC Article
Type of diabetes mellitus: Does it matter to the clinician?
Hoogwerf BJ
Cleve Clin J Med 2020 Feb;87(2):100-108. doi: 10.3949/ccjm.87a.19020. PMID: 32015063

Therapy

Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Zhan Y, Carlsson S
Lancet Glob Health 2023 Mar;11 Suppl 1:S1. doi: 10.1016/S2214-109X(23)00086-4. PMID: 36866468
Adult-onset autoimmune diabetes.
Buzzetti R, Maddaloni E, Gaglia J, Leslie RD, Wong FS, Boehm BO
Nat Rev Dis Primers 2022 Sep 22;8(1):63. doi: 10.1038/s41572-022-00390-6. PMID: 36138034
Latent Autoimmune Diabetes in Adults (LADA): From Immunopathogenesis to Immunotherapy.
Hu J, Zhang R, Zou H, Xie L, Zhou Z, Xiao Y
Front Endocrinol (Lausanne) 2022;13:917169. Epub 2022 Jul 21 doi: 10.3389/fendo.2022.917169. PMID: 35937817Free PMC Article
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.
Buzzetti R, Tuomi T, Mauricio D, Pietropaolo M, Zhou Z, Pozzilli P, Leslie RD
Diabetes 2020 Oct;69(10):2037-2047. Epub 2020 Aug 26 doi: 10.2337/dbi20-0017. PMID: 32847960Free PMC Article
Beta-cell protection and therapy for latent autoimmune diabetes in adults.
Cernea S, Buzzetti R, Pozzilli P
Diabetes Care 2009 Nov;32 Suppl 2(Suppl 2):S246-52. doi: 10.2337/dc09-S317. PMID: 19875559Free PMC Article

Prognosis

All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults.
Wei Y, Herzog K, Ahlqvist E, Andersson T, Nyström T, Zhan Y, Tuomi T, Carlsson S
Diabetes Care 2023 Oct 1;46(10):1857-1865. doi: 10.2337/dc23-0739. PMID: 37635682Free PMC Article
Anti-Islet Autoantibodies in Type 1 Diabetes.
Kawasaki E
Int J Mol Sci 2023 Jun 11;24(12) doi: 10.3390/ijms241210012. PMID: 37373160Free PMC Article
Latent Autoimmune Diabetes in Adults: A Review of Clinically Relevant Issues.
Hernández M, Mauricio D
Adv Exp Med Biol 2021;1307:29-41. doi: 10.1007/5584_2020_533. PMID: 32424495
The clinical consequences of heterogeneity within and between different diabetes types.
Redondo MJ, Hagopian WA, Oram R, Steck AK, Vehik K, Weedon M, Balasubramanyam A, Dabelea D
Diabetologia 2020 Oct;63(10):2040-2048. Epub 2020 Sep 7 doi: 10.1007/s00125-020-05211-7. PMID: 32894314Free PMC Article
Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes.
Sørgjerd EP
Curr Diabetes Rev 2019;15(3):199-204. doi: 10.2174/1573399814666180730105351. PMID: 30058495

Clinical prediction guides

Anti-Islet Autoantibodies in Type 1 Diabetes.
Kawasaki E
Int J Mol Sci 2023 Jun 11;24(12) doi: 10.3390/ijms241210012. PMID: 37373160Free PMC Article
Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Zhan Y, Carlsson S
Lancet Glob Health 2023 Mar;11 Suppl 1:S1. doi: 10.1016/S2214-109X(23)00086-4. PMID: 36866468
Birthweight, BMI in adulthood and latent autoimmune diabetes in adults: a Mendelian randomisation study.
Wei Y, Zhan Y, Löfvenborg JE, Tuomi T, Carlsson S
Diabetologia 2022 Sep;65(9):1510-1518. Epub 2022 May 23 doi: 10.1007/s00125-022-05725-2. PMID: 35606578Free PMC Article
The clinical consequences of heterogeneity within and between different diabetes types.
Redondo MJ, Hagopian WA, Oram R, Steck AK, Vehik K, Weedon M, Balasubramanyam A, Dabelea D
Diabetologia 2020 Oct;63(10):2040-2048. Epub 2020 Sep 7 doi: 10.1007/s00125-020-05211-7. PMID: 32894314Free PMC Article
Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes.
Sørgjerd EP
Curr Diabetes Rev 2019;15(3):199-204. doi: 10.2174/1573399814666180730105351. PMID: 30058495

Recent systematic reviews

The worldwide prevalence of latent autoimmune diabetes of adults among adult-onset diabetic individuals: a systematic review and meta-analysis.
Ramu D, Ramaswamy S, Rao S, Paul SFD
Endocrine 2023 Oct;82(1):28-41. Epub 2023 Jul 10 doi: 10.1007/s12020-023-03424-5. PMID: 37428296
Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta-analysis.
Lin T, Cai Y, Tang L, Lian Y, Liu M, Liu C
J Diabetes Investig 2022 Sep;13(9):1506-1519. Epub 2022 May 6 doi: 10.1111/jdi.13814. PMID: 35445591Free PMC Article
Global epidemiology of type 1 diabetes in young adults and adults: a systematic review.
Diaz-Valencia PA, Bougnères P, Valleron AJ
BMC Public Health 2015 Mar 17;15:255. doi: 10.1186/s12889-015-1591-y. PMID: 25849566Free PMC Article
Interventions for latent autoimmune diabetes (LADA) in adults.
Brophy S, Davies H, Mannan S, Brunt H, Williams R
Cochrane Database Syst Rev 2011 Sep 7;2011(9):CD006165. doi: 10.1002/14651858.CD006165.pub3. PMID: 21901702Free PMC Article
Interventions for latent autoimmune diabetes (LADA) in adults.
Brophy S, Brunt H, Davies H, Mannan S, Williams R
Cochrane Database Syst Rev 2007 Jul 18;(3):CD006165. doi: 10.1002/14651858.CD006165.pub2. PMID: 17636829

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