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Invasive fungal infection

MedGen UID:
899732
•Concept ID:
C1262313
•
Disease or Syndrome
Synonyms: Disseminated Fungal Infection; Disseminated Fungal Infections; Fungal Infection, Disseminated; Fungal Infection, Invasive; Infection, Disseminated Fungal; Infection, Invasive Fungal; Invasive Fungal Infection; Invasive Fungal Infections; Invasive Mycoses; Mycoses, Invasive
SNOMED CT: Invasive fungal infection (12391000132109); Invasive mycosis (12391000132109); Invasive fungal disease (12391000132109)
 
HPO: HP:0020101

Definition

Fungal infection characterized by invasion of host tissues. [from HPO]

Professional guidelines

PubMed

Diagnosis and management of invasive fungal diseases in non-neutropenic ICU patients, with focus on candidiasis and aspergillosis: a comprehensive review.
Azim A, Ahmed A
Front Cell Infect Microbiol 2024;14:1256158. Epub 2024 Mar 5 doi: 10.3389/fcimb.2024.1256158. PMID: 38505289Free PMC Article
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM.
Chang CC, Harrison TS, Bicanic TA, Chayakulkeeree M, Sorrell TC, Warris A, Hagen F, Spec A, Oladele R, Govender NP, Chen SC, Mody CH, Groll AH, Chen YC, Lionakis MS, Alanio A, Castañeda E, Lizarazo J, Vidal JE, Takazono T, Hoenigl M, Alffenaar JW, Gangneux JP, Soman R, Zhu LP, Bonifaz A, Jarvis JN, Day JN, Klimko N, Salmanton-García J, Jouvion G, Meya DB, Lawrence D, Rahn S, Bongomin F, McMullan BJ, Sprute R, Nyazika TK, Beardsley J, Carlesse F, Heath CH, Ayanlowo OO, Mashedi OM, Queiroz-Telles Filho F, Hosseinipour MC, Patel AK, Temfack E, Singh N, Cornely OA, Boulware DR, Lortholary O, Pappas PG, Perfect JR
Lancet Infect Dis 2024 Aug;24(8):e495-e512. Epub 2024 Feb 9 doi: 10.1016/S1473-3099(23)00731-4. PMID: 38346436Free PMC Article
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Bronchopulmonary penetration of isavuconazole in lung transplant recipients.
Caballero-Bermejo AF, Darnaude-Ximénez I, Aguilar-Pérez M, Gomez-Lopez A, Sancho-López A, López García-Gallo C, Díaz Nuevo G, Diago-Sempere E, Ruiz-Antorán B, Avendaño-Solá C, Ussetti-Gil P; PBISA01‐Study Group
Antimicrob Agents Chemother 2023 Oct 18;67(10):e0061323. Epub 2023 Oct 3 doi: 10.1128/aac.00613-23. PMID: 37787528Free PMC Article
Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study.
Puerta-Alcalde P, Monzó-Gallo P, Aguilar-Guisado M, Ramos JC, Laporte-Amargós J, Machado M, Martin-Davila P, Franch-Sarto M, Sánchez-Romero I, Badiola J, Gómez L, Ruiz-Camps I, Yáñez L, Vázquez L, Chumbita M, Marco F, Soriano A, González P, Fernández-Cruz A, Batlle M, Fortún J, Guinea J, Gudiol C, García J, Ruiz Pérez de Pipaón M, Alastruey-Izquierdo A, Garcia-Vidal C
J Infect 2023 Jul;87(1):46-53. Epub 2023 May 16 doi: 10.1016/j.jinf.2023.05.005. PMID: 37201859
Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Mucormycosis in India: unique features.
Chakrabarti A, Singh R
Mycoses 2014 Dec;57 Suppl 3:85-90. Epub 2014 Sep 3 doi: 10.1111/myc.12243. PMID: 25187095

Diagnosis

Diagnosis and management of invasive fungal diseases in non-neutropenic ICU patients, with focus on candidiasis and aspergillosis: a comprehensive review.
Azim A, Ahmed A
Front Cell Infect Microbiol 2024;14:1256158. Epub 2024 Mar 5 doi: 10.3389/fcimb.2024.1256158. PMID: 38505289Free PMC Article
Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Invasive Candidiasis.
Gonzalez-Lara MF, Ostrosky-Zeichner L
Semin Respir Crit Care Med 2020 Feb;41(1):3-12. Epub 2020 Jan 30 doi: 10.1055/s-0040-1701215. PMID: 32000280
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article

Therapy

Isavuconazole use and TDM in real-world pediatric practice.
Fernández Ledesma B, Mendoza-Palomar N, Melendo Pérez S, Fernández-Polo A, Renedo Miró B, Pau Parra A, Luque Pardos S, Grau Cerrato S, Vima Bofarull J, Martín-Gómez MT, Pujol Jover M, Benítez-Carbante MI, Díaz de Heredia C, Soler-Palacin P
Antimicrob Agents Chemother 2023 Dec 14;67(12):e0082923. Epub 2023 Nov 14 doi: 10.1128/aac.00829-23. PMID: 37962334Free PMC Article
Antifungal prophylaxis and pre-emptive therapy: When and how?
Sprute R, Nacov JA, Neofytos D, Oliverio M, Prattes J, Reinhold I, Cornely OA, Stemler J
Mol Aspects Med 2023 Aug;92:101190. Epub 2023 May 17 doi: 10.1016/j.mam.2023.101190. PMID: 37207579
Pulmonary Aspergillosis: What the Generalist Needs to Know.
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Triazole antifungals: a review.
Peyton LR, Gallagher S, Hashemzadeh M
Drugs Today (Barc) 2015 Dec;51(12):705-18. doi: 10.1358/dot.2015.51.12.2421058. PMID: 26798851

Prognosis

How do I manage refractory invasive pulmonary aspergillosis.
Vergidis P, Sendi P, Alkhateeb HB, Nguyen MH
Clin Microbiol Infect 2024 Jun;30(6):755-761. Epub 2024 Jan 28 doi: 10.1016/j.cmi.2024.01.015. PMID: 38286175
Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Mucormycosis in India: unique features.
Chakrabarti A, Singh R
Mycoses 2014 Dec;57 Suppl 3:85-90. Epub 2014 Sep 3 doi: 10.1111/myc.12243. PMID: 25187095

Clinical prediction guides

Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.
Fontana L, Perlin DS, Zhao Y, Noble BN, Lewis JS, Strasfeld L, Hakki M
Clin Infect Dis 2020 Feb 14;70(5):723-730. doi: 10.1093/cid/ciz282. PMID: 30958538Free PMC Article
Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients.
John J, Loo A, Mazur S, Walsh TJ
Expert Opin Drug Metab Toxicol 2019 Nov;15(11):881-895. Epub 2019 Oct 30 doi: 10.1080/17425255.2019.1671971. PMID: 31550939
Acute respiratory failure in immunocompromised adults.
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.
Timsit JF, Azoulay E, Schwebel C, Charles PE, Cornet M, Souweine B, Klouche K, Jaber S, Trouillet JL, Bruneel F, Argaud L, Cousson J, Meziani F, Gruson D, Paris A, Darmon M, Garrouste-Orgeas M, Navellou JC, Foucrier A, Allaouchiche B, Das V, Gangneux JP, Ruckly S, Maubon D, Jullien V, Wolff M; EMPIRICUS Trial Group
JAMA 2016 Oct 18;316(15):1555-1564. doi: 10.1001/jama.2016.14655. PMID: 27706483
Cryptococcus: from environmental saprophyte to global pathogen.
May RC, Stone NR, Wiesner DL, Bicanic T, Nielsen K
Nat Rev Microbiol 2016 Feb;14(2):106-17. Epub 2015 Dec 21 doi: 10.1038/nrmicro.2015.6. PMID: 26685750Free PMC Article

Recent systematic reviews

Progression of noninvasive fungal sinusitis to invasive fungal sinusitis: A systematic review.
Goyal SS, Doering M, Kendall PL, Farrell N, Schneider JS, Roland LT
Int Forum Allergy Rhinol 2023 Jun;13(6):1024-1033. Epub 2022 Nov 8 doi: 10.1002/alr.23097. PMID: 36305427
Comparative efficacy and safety of systemic antifungal agents for candidemia: a systematic review with network meta-analysis and multicriteria acceptability analyses.
Domingos EL, Vilhena RO, Santos JMMF, Fachi MM, Böger B, Adam LM, Tonin FS, Pontarolo R
Int J Antimicrob Agents 2022 Aug;60(2):106614. Epub 2022 Jun 9 doi: 10.1016/j.ijantimicag.2022.106614. PMID: 35691603
Invasive fungal infections in acute and chronic liver impairment: A systematic review.
Lahmer T, Peçanha-Pietrobom PM, Schmid RM, Colombo AL
Mycoses 2022 Feb;65(2):140-151. Epub 2021 Dec 8 doi: 10.1111/myc.13403. PMID: 34837414
Cryptococcus and cryptococcosis in Iran during 1969-2019: A systematic review and meta-analysis.
Bandalizadeh Z, Javidnia J, Hosseini SA, Moosazadeh M, Amouei A, Kermani F, Seyedmousavi S, Shokohi T
J Mycol Med 2020 Apr;30(1):100917. Epub 2019 Dec 6 doi: 10.1016/j.mycmed.2019.100917. PMID: 31864801
Intensive care medicine research agenda on invasive fungal infection in critically ill patients.
Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA
Intensive Care Med 2017 Sep;43(9):1225-1238. Epub 2017 Mar 2 doi: 10.1007/s00134-017-4731-2. PMID: 28255613

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