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Decreased level of histidine-rich glycoprotein

MedGen UID:: 907379
•Concept ID:: C4280716
•: Finding

HPO:	HP:0040227

Definition

Decrease of these levels result in increased inhibition of fibrinolysis and reduced inhibition of coagulation [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDecreased level of histidine-rich glycoprotein

Phenotypic abnormality
- Abnormality of blood and blood-forming tissues
  - Abnormality of coagulation
    - Abnormality of the coagulation cascade
      - Abnormality of the common coagulation pathway
        Decreased level of histidine-rich glycoprotein

Conditions with this feature

Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency

MedGen UID:: 416465
•Concept ID:: C2751090
•: Disease or Syndrome

Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency is a rare, genetic, coagulation disorder characterized by a tendency to develop thrombosis, resulting from decreased histidine-rich glycoprotein (HRG) plasma levels. Manifestations are variable depending on location of thrombosis, but may include headaches, diplopia, progressive pain, limb swelling, itching or ulceration, and brownish skin discoloration, among others.

See: Condition Record

Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency

Professional guidelines

PubMed

Coagulation disorders associated with acute promyelocytic leukemia: corrective effect of all-trans retinoic acid treatment.

Dombret H, Scrobohaci ML, Ghorra P, Zini JM, Daniel MT, Castaigne S, Degos L
Leukemia 1993 Jan;7(1):2-9. PMID: 8418375

See all (1)

Recent clinical studies

Etiology

Decreased levels of histidine-rich glycoprotein and increased levels of high-mobility group box 1 are risk factors for refractory Kawasaki disease.

Namba T, Yashiro M, Fujii Y, Tsuge M, Liu K, Nishibori M, Tsukahara H
Mod Rheumatol 2023 Apr 13;33(3):599-607. doi: 10.1093/mr/roac040. PMID: 35484824

Histidine-rich glycoprotein as a novel predictive biomarker of postoperative complications in intensive care unit patients: a prospective observational study.

Oiwa M, Kuroda K, Kawanoue N, Morimatsu H
BMC Anesthesiol 2022 Jul 20;22(1):232. doi: 10.1186/s12871-022-01774-7. PMID: 35858852 Free PMC Article

Decrease in Histidine-Rich Glycoprotein as a Novel Biomarker to Predict Sepsis Among Systemic Inflammatory Response Syndrome.

Kuroda K, Wake H, Mori S, Hinotsu S, Nishibori M, Morimatsu H
Crit Care Med 2018 Apr;46(4):570-576. doi: 10.1097/CCM.0000000000002947. PMID: 29303798

Histidine-rich glycoprotein as an early biomarker of preeclampsia.

Bolin M, Akerud P, Hansson A, Akerud H
Am J Hypertens 2011 Apr;24(4):496-501. Epub 2011 Jan 20 doi: 10.1038/ajh.2010.264. PMID: 21252863

Effects of newer oral contraceptives on the inhibition of coagulation and fibrinolysis in relation to dosage and type of steroid.

Jespersen J, Petersen KR, Skouby SO
Am J Obstet Gynecol 1990 Jul;163(1 Pt 2):396-403. doi: 10.1016/0002-9378(90)90590-4. PMID: 2196812

See all (18)

Diagnosis

CHANGES OF HISTIDINE-RICH GLYCOPROTEIN LEVELS IN CRITICALLY ILL SEPTIC PATIENTS.

Pradana ANK, Akahoshi T, Guo J, Mizuta Y, Matsunaga S, Narahara S, Murata M, Yamaura K
Shock 2024 Sep 1;62(3):351-356. Epub 2024 Jun 25 doi: 10.1097/SHK.0000000000002406. PMID: 38935033 Free PMC Article

Decreased levels of histidine-rich glycoprotein and increased levels of high-mobility group box 1 are risk factors for refractory Kawasaki disease.

Namba T, Yashiro M, Fujii Y, Tsuge M, Liu K, Nishibori M, Tsukahara H
Mod Rheumatol 2023 Apr 13;33(3):599-607. doi: 10.1093/mr/roac040. PMID: 35484824

Histidine-rich glycoprotein as a novel predictive biomarker of postoperative complications in intensive care unit patients: a prospective observational study.

Oiwa M, Kuroda K, Kawanoue N, Morimatsu H
BMC Anesthesiol 2022 Jul 20;22(1):232. doi: 10.1186/s12871-022-01774-7. PMID: 35858852 Free PMC Article

Histidine-rich glycoprotein as a prognostic biomarker for sepsis.

Kuroda K, Ishii K, Mihara Y, Kawanoue N, Wake H, Mori S, Yoshida M, Nishibori M, Morimatsu H
Sci Rep 2021 May 13;11(1):10223. doi: 10.1038/s41598-021-89555-z. PMID: 33986340 Free PMC Article

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.

Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE
mBio 2016 Jun 7;7(3) doi: 10.1128/mBio.00617-16. PMID: 27273825 Free PMC Article

See all (16)

Therapy

Decreased levels of histidine-rich glycoprotein and increased levels of high-mobility group box 1 are risk factors for refractory Kawasaki disease.

Namba T, Yashiro M, Fujii Y, Tsuge M, Liu K, Nishibori M, Tsukahara H
Mod Rheumatol 2023 Apr 13;33(3):599-607. doi: 10.1093/mr/roac040. PMID: 35484824

A novel biomarker of serum Histidine-Rich Glycoprotein (HRG) for diagnosing and predicting prognosis of ventilator-associated pneumonia (VAP): a pilot study.

Ding HG, Zhou HF, Diao MY, Xu Y, Pan QM, Shen XH
Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7920-7927. doi: 10.26355/eurrev_201811_16419. PMID: 30536339

Estrogens reduce plasma histidine-rich glycoprotein (HRG) levels in a dose-dependent way.

Hennis BC, Boomsma DI, Fijnvandraat K, Gevers Leuven JA, Peters M, Kluft C
Thromb Haemost 1995 Mar;73(3):484-7. PMID: 7667832

Effects of newer oral contraceptives on the inhibition of coagulation and fibrinolysis in relation to dosage and type of steroid.

Jespersen J, Petersen KR, Skouby SO
Am J Obstet Gynecol 1990 Jul;163(1 Pt 2):396-403. doi: 10.1016/0002-9378(90)90590-4. PMID: 2196812

Serum histidine-rich glycoprotein levels are decreased in acquired immune deficiency syndrome and by steroid therapy.

Morgan WT
Biochem Med Metab Biol 1986 Oct;36(2):210-3. doi: 10.1016/0885-4505(86)90127-1. PMID: 3778686

See all (14)

Prognosis

CHANGES OF HISTIDINE-RICH GLYCOPROTEIN LEVELS IN CRITICALLY ILL SEPTIC PATIENTS.

Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis.

Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Casalino A, Bocca C, Novo E, Protopapa F, Ramavath NN, Provera A, Gambella A, Bugianesi E, Tacke F, Albano E, Parola M
Front Immunol 2024;15:1342404. Epub 2024 Feb 26 doi: 10.3389/fimmu.2024.1342404. PMID: 38469298 Free PMC Article

Histidine-rich glycoprotein as a novel predictive biomarker of postoperative complications in intensive care unit patients: a prospective observational study.

Oiwa M, Kuroda K, Kawanoue N, Morimatsu H
BMC Anesthesiol 2022 Jul 20;22(1):232. doi: 10.1186/s12871-022-01774-7. PMID: 35858852 Free PMC Article

Histidine-rich glycoprotein as a prognostic biomarker for sepsis.

Kuroda K, Ishii K, Mihara Y, Kawanoue N, Wake H, Mori S, Yoshida M, Nishibori M, Morimatsu H
Sci Rep 2021 May 13;11(1):10223. doi: 10.1038/s41598-021-89555-z. PMID: 33986340 Free PMC Article

Histidine-rich glycoprotein as an early biomarker of preeclampsia.

Bolin M, Akerud P, Hansson A, Akerud H
Am J Hypertens 2011 Apr;24(4):496-501. Epub 2011 Jan 20 doi: 10.1038/ajh.2010.264. PMID: 21252863

See all (10)

Clinical prediction guides

Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis.

Histidine-rich glycoprotein as a prognostic biomarker for sepsis.

Kuroda K, Ishii K, Mihara Y, Kawanoue N, Wake H, Mori S, Yoshida M, Nishibori M, Morimatsu H
Sci Rep 2021 May 13;11(1):10223. doi: 10.1038/s41598-021-89555-z. PMID: 33986340 Free PMC Article

Decreased Levels of Histidine-Rich Glycoprotein in Advanced Lung Cancer: Association with Prothrombotic Alterations.

Winiarska A, Zareba L, Krolczyk G, Czyzewicz G, Zabczyk M, Undas A
Dis Markers 2019;2019:8170759. Epub 2019 Mar 3 doi: 10.1155/2019/8170759. PMID: 30944671 Free PMC Article

Histidine-Rich Glycoprotein Suppresses Hyperinflammatory Responses of Lung in a Severe Acute Pancreatitis Mouse Model.

Terao K, Wake H, Adachi N, Liu K, Teshigawara K, Takahashi H, Mori S, Nishibori M
Pancreas 2018 Oct;47(9):1156-1164. doi: 10.1097/MPA.0000000000001153. PMID: 30192316 Free PMC Article

Histidine-rich glycoprotein as an early biomarker of preeclampsia.

Bolin M, Akerud P, Hansson A, Akerud H
Am J Hypertens 2011 Apr;24(4):496-501. Epub 2011 Jan 20 doi: 10.1038/ajh.2010.264. PMID: 21252863

See all (23)

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Decreased level of histidine-rich glycoprotein

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

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Reviews

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