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Adenocarcinoma in Multiple Adenomatous Polyps

MedGen UID:
90757
•Concept ID:
C0334295
•
Neoplastic Process
Synonym: Adenocarcinoma in multiple adenomatous polyps
SNOMED CT: Adenocarcinoma in multiple adenomatous polyps (47299001)

Definition

Adenocarcinomas developing in gastrointestinal tract adenomas in patients with multiple adenomatous polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma in Multiple Adenomatous Polyps

Professional guidelines

PubMed

Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experience.
Jaganmohan S, Lynch PM, Raju RP, Ross WA, Lee JE, Raju GS, Bhutani MS, Fleming JB, Lee JH
Dig Dis Sci 2012 Mar;57(3):732-7. Epub 2011 Sep 30 doi: 10.1007/s10620-011-1917-2. PMID: 21960285
Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients.
Ito Y, Miyauchi A, Ishikawa H, Hirokawa M, Kudo T, Tomoda C, Miya A
Endocr J 2011;58(8):685-9. Epub 2011 Jun 14 doi: 10.1507/endocrj.ej11-0022. PMID: 21670544
Nonampullary duodenal polyps: characteristics and endoscopic management.
Abbass R, Rigaux J, Al-Kawas FH
Gastrointest Endosc 2010 Apr;71(4):754-9. doi: 10.1016/j.gie.2009.11.043. PMID: 20363416

Recent clinical studies

Etiology

Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Hepatobiliary and Pancreatic: Hepatic nodules in a patient with familial adenomatous polyposis and colorectal adenocarcinoma.
Crimì F, Guido M, Pomerri F
J Gastroenterol Hepatol 2018 Jan;33(1):8. doi: 10.1111/jgh.13972. PMID: 29284077
Heritable Gastrointestinal Cancer Syndromes.
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article
Familial polyposis coli & Gardner's syndrome.
Nannery WM, Barone JG, Abouchedid C
N J Med 1990 Sep;87(9):731-3. PMID: 2172875

Diagnosis

Attenuated Familial Adenomatous Polyposis.
Eizuka M, Toya Y, Kosaka T, Oizumi T, Morishita T, Kasugai S, Yanai S, Sugai T, Matsumoto T
Intern Med 2023 Sep 15;62(18):2651-2654. Epub 2023 Feb 1 doi: 10.2169/internalmedicine.1101-22. PMID: 36725040Free PMC Article
Endoscopic submucosal dissection for multiple gastric superficial adenocarcinomas identified in patient with familial adenomatous polyposis.
Negishi R, Koizumi K, Ohata K
Dig Endosc 2020 May;32(4):e57-e58. Epub 2020 Feb 11 doi: 10.1111/den.13607. PMID: 32043670
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Heritable Gastrointestinal Cancer Syndromes.
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Familial polyposis coli & Gardner's syndrome.
Nannery WM, Barone JG, Abouchedid C
N J Med 1990 Sep;87(9):731-3. PMID: 2172875

Therapy

Hepatobiliary and Pancreatic: Hepatic nodules in a patient with familial adenomatous polyposis and colorectal adenocarcinoma.
Crimì F, Guido M, Pomerri F
J Gastroenterol Hepatol 2018 Jan;33(1):8. doi: 10.1111/jgh.13972. PMID: 29284077
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
Bronchioloalveolar adenocarcinoma and pulmonary langerhans cell histiocytosis in a patient with MUTYH-associated polyposis.
von der Thüsen JH, van de Wetering MD, Westermann AM, Heideman DA, Thunnissen E
J Clin Oncol 2011 Mar 10;29(8):e188-90. Epub 2010 Dec 28 doi: 10.1200/JCO.2010.32.1026. PMID: 21189386
Sulindac therapy of colorectal polyps in familial adenomatous polyposis.
Tonelli F, Valanzano R, Dolara P
Dig Dis 1994 Sep-Oct;12(5):259-64. doi: 10.1159/000171461. PMID: 7882547

Prognosis

Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
An innovative technique for colorectal specimen retrieval: a new era of "natural orifice specimen extraction" (N.O.S.E).
Palanivelu C, Rangarajan M, Jategaonkar PA, Anand NV
Dis Colon Rectum 2008 Jul;51(7):1120-4. Epub 2008 May 15 doi: 10.1007/s10350-008-9316-2. PMID: 18481149
Familial polyposis coli & Gardner's syndrome.
Nannery WM, Barone JG, Abouchedid C
N J Med 1990 Sep;87(9):731-3. PMID: 2172875

Clinical prediction guides

GI Polyps and Polyposis in Individuals Harboring Germline CHEK2 Mutations.
Chang C, Lee JE, Waters KM, Larson BK
Dis Colon Rectum 2024 Oct 1;67(10):1291-1303. Epub 2024 Jul 3 doi: 10.1097/DCR.0000000000003365. PMID: 38959470
Twenty cases of gastric adenocarcinoma of the fundic gland type.
Yang M, Sun X, Chen Y, Yang P
Scand J Gastroenterol 2023 Jul;58(7):744-750. Epub 2023 Jan 5 doi: 10.1080/00365521.2022.2164213. PMID: 36604805
Large-cell neuroendocrine carcinoma arising from a gastritis cystica polyposa.
Kusunoki R, Fujishiro H, Onoda Y, Suemitsu S, Fujiwara A, Tsukano K, Kotani S, Kuroki D, Ogawa S, Yamanouchi S, Aimi M, Ito S, Miyaoka Y, Miyake T, Kohge N, Imaoka T, Takamura M, Ohnuma H, Ishihara S, Kinoshita Y
Clin J Gastroenterol 2018 Apr;11(2):133-137. Epub 2018 Jan 5 doi: 10.1007/s12328-017-0816-2. PMID: 29305822
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Sulindac therapy of colorectal polyps in familial adenomatous polyposis.
Tonelli F, Valanzano R, Dolara P
Dig Dis 1994 Sep-Oct;12(5):259-64. doi: 10.1159/000171461. PMID: 7882547

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