Malignant Spitz tumor

MedGen UID:: 90784
•Concept ID:: C0334442
•: Neoplastic Process

Synonym:	MST - malignant Spitz tumor
SNOMED CT:	Malignant Spitz tumor (1295231007); MST - malignant Spitz tumor (1295231007); Malignant Spitz tumor (1295233005)

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Spitz tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Melanoma
        Malignant Spitz tumor
        Mixed cell uveal melanoma
        Choroid mixed cell melanoma
        Ciliary body mixed cell melanoma
        Iris Mixed Cell Melanoma

Professional guidelines

PubMed

Blood-Based Biomarker Panel for Personalized Lung Cancer Risk Assessment.

Fahrmann JF, Marsh T, Irajizad E, Patel N, Murage E, Vykoukal J, Dennison JB, Do KA, Ostrin E, Spitz MR, Lam S, Shete S, Meza R, Tammemägi MC, Feng Z, Hanash SM
J Clin Oncol 2022 Mar 10;40(8):876-883. Epub 2022 Jan 7 doi: 10.1200/JCO.21.01460. PMID: 34995129 Free PMC Article

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.

Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479

Spitz nevi: defining features and management in children.

Neri I, Dika E, Ravaioli GM, Patrizi A
G Ital Dermatol Venereol 2014 Dec;149(6):675-82. Epub 2014 Oct 3 PMID: 25279496

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Recent clinical studies

Etiology

Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases.

Šekoranja D, Zupan A, Matjašič A, Boštjančič E, Calonje E, Pižem J
J Cutan Pathol 2025 Feb;52(2):141-153. Epub 2024 Nov 7 doi: 10.1111/cup.14750. PMID: 39511946 Free PMC Article

The Morpho-Molecular Landscape of Spitz Neoplasms.

Dal Pozzo CA, Cappellesso R
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084211. PMID: 35457030 Free PMC Article

MAP2K1-Mutated Melanocytic Neoplasms With a SPARK-Like Morphology.

Donati M, Nosek D, Waldenbäck P, Martinek P, Jonsson BA, Galgonkova P, Hawawrehova M, Berouskova P, Kastnerova L, Persichetti P, Crescenzi A, Michal M, Kazakov DV
Am J Dermatopathol 2021 Jun 1;43(6):412-417. doi: 10.1097/DAD.0000000000001840. PMID: 33264134

A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms.

Hillen LM, Geybels MS, Spassova I, Becker JC, Gambichler T, Garmyn M, Zur Hausen A, van den Oord J, Winnepenninckx V
FEBS Open Bio 2020 Jul;10(7):1326-1341. Epub 2020 Jun 5 doi: 10.1002/2211-5463.12897. PMID: 32431053 Free PMC Article

Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations.

Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A
Mod Pathol 2020 May;33(5):846-857. Epub 2019 Nov 12 doi: 10.1038/s41379-019-0384-8. PMID: 31719662

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Diagnosis

Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms-An Analysis of 70 Cases.

Šekoranja D, Zupan A, Matjašič A, Boštjančič E, Calonje E, Pižem J
J Cutan Pathol 2025 Feb;52(2):141-153. Epub 2024 Nov 7 doi: 10.1111/cup.14750. PMID: 39511946 Free PMC Article

The Morpho-Molecular Landscape of Spitz Neoplasms.

Dal Pozzo CA, Cappellesso R
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084211. PMID: 35457030 Free PMC Article

Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations.

See all (3)