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Acquired red cell aplasia

MedGen UID:
90957
•Concept ID:
C0340961
•
Disease or Syndrome
Synonyms: Acquired Pure Red Cell Aplasia; Acquired pure red cell aplasia
SNOMED CT: Acquired red cell aplasia (234376007); Acquired pure red cell aplasia (234376007)

Definition

A disease characterized by normocytic, normochromic anemia, low hematocrit, reticulocytopenia and selective erythroid hypoplasia. It can occur as a chronic or acute form; the former is predominantly seen in adults and the latter in children. Pathogenesis involves immune dysfunction with antibodies directed against erythroid precursor cells or erythropoietin, or due to T-cell mediated suppression of erythropoiesis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcquired red cell aplasia

Professional guidelines

PubMed

Guidelines on the use of intravenous immune globulin for hematologic conditions.
Anderson D, Ali K, Blanchette V, Brouwers M, Couban S, Radmoor P, Huebsch L, Hume H, McLeod A, Meyer R, Moltzan C, Nahirniak S, Nantel S, Pineo G, Rock G
Transfus Med Rev 2007 Apr;21(2 Suppl 1):S9-56. doi: 10.1016/j.tmrv.2007.01.001. PMID: 17397769

Recent clinical studies

Etiology

Red cell aplasia and autoimmune hemolytic anemia following immunosuppression with alemtuzumab, mycophenolate, and daclizumab in pancreas transplant recipients.
Elimelakh M, Dayton V, Park KS, Gruessner AC, Sutherland D, Howe RB, Reding MT, Eastlund T, van Burik JA, Singleton TP, Gruessner RW, Key NS
Haematologica 2007 Aug;92(8):1029-36. Epub 2007 Jul 20 doi: 10.3324/haematol.10733. PMID: 17640860

Diagnosis

Red cell aplasia and autoimmune hemolytic anemia following immunosuppression with alemtuzumab, mycophenolate, and daclizumab in pancreas transplant recipients.
Elimelakh M, Dayton V, Park KS, Gruessner AC, Sutherland D, Howe RB, Reding MT, Eastlund T, van Burik JA, Singleton TP, Gruessner RW, Key NS
Haematologica 2007 Aug;92(8):1029-36. Epub 2007 Jul 20 doi: 10.3324/haematol.10733. PMID: 17640860

Therapy

Red cell aplasia and autoimmune hemolytic anemia following immunosuppression with alemtuzumab, mycophenolate, and daclizumab in pancreas transplant recipients.
Elimelakh M, Dayton V, Park KS, Gruessner AC, Sutherland D, Howe RB, Reding MT, Eastlund T, van Burik JA, Singleton TP, Gruessner RW, Key NS
Haematologica 2007 Aug;92(8):1029-36. Epub 2007 Jul 20 doi: 10.3324/haematol.10733. PMID: 17640860
Guidelines on the use of intravenous immune globulin for hematologic conditions.
Anderson D, Ali K, Blanchette V, Brouwers M, Couban S, Radmoor P, Huebsch L, Hume H, McLeod A, Meyer R, Moltzan C, Nahirniak S, Nantel S, Pineo G, Rock G
Transfus Med Rev 2007 Apr;21(2 Suppl 1):S9-56. doi: 10.1016/j.tmrv.2007.01.001. PMID: 17397769
Acquired red cell aplasia in association with the use of recombinant erythropoietin in chronic renal failure.
Lim LC
Hematology 2005 Jun;10(3):255-9. doi: 10.1080/10245330400026154. PMID: 16019474
Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia.
Leonard EM, Raefsky E, Griffith P, Kimball J, Nienhuis AW, Young NS
Br J Haematol 1989 Jun;72(2):278-84. doi: 10.1111/j.1365-2141.1989.tb07695.x. PMID: 2503027
Pure red cell aplasia.
Beard ME, Krantz SB, Johnson SA, Bateman CJ, Whitehouse JM
Q J Med 1978 Jul;47(187):339-48. PMID: 715172

Prognosis

Red cell aplasia and autoimmune hemolytic anemia following immunosuppression with alemtuzumab, mycophenolate, and daclizumab in pancreas transplant recipients.
Elimelakh M, Dayton V, Park KS, Gruessner AC, Sutherland D, Howe RB, Reding MT, Eastlund T, van Burik JA, Singleton TP, Gruessner RW, Key NS
Haematologica 2007 Aug;92(8):1029-36. Epub 2007 Jul 20 doi: 10.3324/haematol.10733. PMID: 17640860
Acquired red cell aplasia in association with the use of recombinant erythropoietin in chronic renal failure.
Lim LC
Hematology 2005 Jun;10(3):255-9. doi: 10.1080/10245330400026154. PMID: 16019474
Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia.
Leonard EM, Raefsky E, Griffith P, Kimball J, Nienhuis AW, Young NS
Br J Haematol 1989 Jun;72(2):278-84. doi: 10.1111/j.1365-2141.1989.tb07695.x. PMID: 2503027

Clinical prediction guides

Pure red cell aplasia.
Beard ME, Krantz SB, Johnson SA, Bateman CJ, Whitehouse JM
Q J Med 1978 Jul;47(187):339-48. PMID: 715172

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