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Acquired Fanconi syndrome

MedGen UID:
90966
•Concept ID:
C0341702
•
Disease or Syndrome
Synonyms: Acquired Fanconi Syndrome; acquired Fanconi syndrome; Secondary Fanconi syndrome
SNOMED CT: Acquired Fanconi syndrome (236467001); Secondary Fanconi syndrome (236467001)
 
Monarch Initiative: MONDO:0060779

Definition

Fanconi Syndrome caused by exposure to noxious agents. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcquired Fanconi syndrome

Professional guidelines

PubMed

Cytogenetics in the management of bone marrow failure syndromes: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Cuccuini W, Collonge-Rame MA, Auger N, Douet-Guilbert N, Coster L, Lafage-Pochitaloff M
Curr Res Transl Med 2023 Oct-Dec;71(4):103423. Epub 2023 Oct 18 doi: 10.1016/j.retram.2023.103423. PMID: 38016422
Primary Sjӧgren's syndrome with renal Fanconi syndrome: Good responses to treatment with glucocorticoids.
Shi X, Chen Z, Wang J, Wen Y, Zou L, Fei Y, Ye W, Qin Y, Li H, Li M, Li X, Zhang F, Li X, Chen L
Semin Arthritis Rheum 2020 Dec;50(6):1326-1332. Epub 2020 May 15 doi: 10.1016/j.semarthrit.2020.03.017. PMID: 32418614
Diagnosis, genetics, and management of inherited bone marrow failure syndromes.
Alter BP
Hematology Am Soc Hematol Educ Program 2007:29-39. doi: 10.1182/asheducation-2007.1.29. PMID: 18024606

Recent clinical studies

Etiology

Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series.
Xu Q, Chen G, Wen Y, Shi X, Ye W, Qin Y, Li X
Clin Rheumatol 2024 Jul;43(7):2329-2336. Epub 2024 May 10 doi: 10.1007/s10067-024-06997-2. PMID: 38730122
Severe hypophosphatemia induced by denosumab in a patient with osteomalacia and tenofovir disoproxil fumarate-related acquired Fanconi syndrome.
Chung TL, Chen NC, Chen CL
Osteoporos Int 2019 Feb;30(2):519-523. Epub 2018 Aug 31 doi: 10.1007/s00198-018-4679-2. PMID: 30171299
A single-center case series of eight patients with the rare plasma cell dyscrasia of acquired Fanconi syndrome secondary to monoclonal gammopathy.
Liu Y, Zhu T, Xu L, Qin Y, Zhuang J
Leuk Lymphoma 2015;56(11):3124-8. Epub 2015 Apr 7 doi: 10.3109/10428194.2015.1025392. PMID: 25791236
Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma.
Ma CX, Lacy MQ, Rompala JF, Dispenzieri A, Rajkumar SV, Greipp PR, Fonseca R, Kyle RA, Gertz MA
Blood 2004 Jul 1;104(1):40-2. Epub 2004 Mar 9 doi: 10.1182/blood-2003-10-3400. PMID: 15010372
Granulomatous nephritis and chronic renal failure in sarcoidosis. Long-term follow-up studies in two patients.
Farge D, Lioté F, Turner M, Barré P, Jothy S
Am J Nephrol 1986;6(1):21-7. doi: 10.1159/000167048. PMID: 3963056

Diagnosis

Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series.
Xu Q, Chen G, Wen Y, Shi X, Ye W, Qin Y, Li X
Clin Rheumatol 2024 Jul;43(7):2329-2336. Epub 2024 May 10 doi: 10.1007/s10067-024-06997-2. PMID: 38730122
Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia.
Ryuge A, Saito S, Morioka H, Hachiya A, Kato N, Ishimoto T, Kosugi T, Maruyama S
Intern Med 2021 Mar 1;60(5):761-764. Epub 2020 Sep 30 doi: 10.2169/internalmedicine.5932-20. PMID: 32999244Free PMC Article
A case of entecavir-induced Fanconi syndrome.
Fujii T, Kawasoe K, Ohta A, Nitta K
CEN Case Rep 2019 Nov;8(4):256-260. Epub 2019 Jun 1 doi: 10.1007/s13730-019-00404-5. PMID: 31154657Free PMC Article
Acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab.
Shaikh A, Wiisanen ME, Gunderson HD, Leung N
Ann Pharmacother 2009 Jul;43(7):1370-3. Epub 2009 Jul 7 doi: 10.1345/aph.1M120. PMID: 19584382
Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma.
Ma CX, Lacy MQ, Rompala JF, Dispenzieri A, Rajkumar SV, Greipp PR, Fonseca R, Kyle RA, Gertz MA
Blood 2004 Jul 1;104(1):40-2. Epub 2004 Mar 9 doi: 10.1182/blood-2003-10-3400. PMID: 15010372

Therapy

Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series.
Xu Q, Chen G, Wen Y, Shi X, Ye W, Qin Y, Li X
Clin Rheumatol 2024 Jul;43(7):2329-2336. Epub 2024 May 10 doi: 10.1007/s10067-024-06997-2. PMID: 38730122
A case of entecavir-induced Fanconi syndrome.
Fujii T, Kawasoe K, Ohta A, Nitta K
CEN Case Rep 2019 Nov;8(4):256-260. Epub 2019 Jun 1 doi: 10.1007/s13730-019-00404-5. PMID: 31154657Free PMC Article
Legionella Pneumonia Complicated with Acquired Fanconi Syndrome.
Koda R, Itoh R, Tsuchida M, Ohashi K, Iino N, Takada T, Narita I
Intern Med 2018 Oct 15;57(20):2975-2980. Epub 2018 Jun 6 doi: 10.2169/internalmedicine.0942-18. PMID: 29877286Free PMC Article
Severe hypocalcemia after denosumab in a patient with acquired Fanconi syndrome.
Shafqat H, Alquadan KF, Olszewski AJ
Osteoporos Int 2014 Mar;25(3):1187-90. Epub 2013 Oct 25 doi: 10.1007/s00198-013-2533-0. PMID: 24158473
Fanconi syndrome associated with cephalothin and gentamicin therapy.
Schwartz JH, Schein P
Cancer 1978 Feb;41(2):769-72. doi: 10.1002/1097-0142(197802)41:2<769::aid-cncr2820410251>3.0.co;2-c. PMID: 343914

Prognosis

Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series.
Xu Q, Chen G, Wen Y, Shi X, Ye W, Qin Y, Li X
Clin Rheumatol 2024 Jul;43(7):2329-2336. Epub 2024 May 10 doi: 10.1007/s10067-024-06997-2. PMID: 38730122
Fanconi syndrome in an elderly patient with membranous nephropathy during treatment with the immunosuppressant mizoribine.
Nishikawa S, Takahashi N, Nishikawa Y, Yokoi S, Morita S, Shimamoto Y, Sakashita S, Nishimori K, Kobayashi M, Fukushima S, Mikami D, Kimura H, Kasuno K, Naiki H, Iwano M
CEN Case Rep 2023 Feb;12(1):32-38. Epub 2022 Jun 24 doi: 10.1007/s13730-022-00715-0. PMID: 35749014Free PMC Article
A single-center case series of eight patients with the rare plasma cell dyscrasia of acquired Fanconi syndrome secondary to monoclonal gammopathy.
Liu Y, Zhu T, Xu L, Qin Y, Zhuang J
Leuk Lymphoma 2015;56(11):3124-8. Epub 2015 Apr 7 doi: 10.3109/10428194.2015.1025392. PMID: 25791236
Fanconi syndrome caused by low-dose adefovir dipivoxil.
Zhu LN, Mou LJ, Hu Y, Chen JX
Saudi Med J 2014 Mar;35(3):309-13. PMID: 24623213
Fanconi syndrome associated with cephalothin and gentamicin therapy.
Schwartz JH, Schein P
Cancer 1978 Feb;41(2):769-72. doi: 10.1002/1097-0142(197802)41:2<769::aid-cncr2820410251>3.0.co;2-c. PMID: 343914

Clinical prediction guides

Acquired Fanconi syndrome in patients with Legionella pneumonia.
Kinoshita-Katahashi N, Fukasawa H, Ishigaki S, Isobe S, Imokawa S, Fujigaki Y, Furuya R
BMC Nephrol 2013 Aug 2;14:171. doi: 10.1186/1471-2369-14-171. PMID: 23915094Free PMC Article
Acquired fanconi syndrome with osteomalacia secondary to monoclonal gammopathy of undetermined significance.
Hashimoto T, Arakawa K, Ohta Y, Suehiro T, Uesugi N, Nakayama M, Tsuchihashi T
Intern Med 2007;46(5):241-5. Epub 2007 Mar 1 doi: 10.2169/internalmedicine.46.1882. PMID: 17329920
Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome.
Sirac C, Bridoux F, Carrion C, Devuyst O, Fernandez B, Goujon JM, El Hamel C, Aldigier JC, Touchard G, Cogné M
Blood 2006 Jul 15;108(2):536-43. Epub 2006 Mar 16 doi: 10.1182/blood-2005-11-4419. PMID: 16543471
An adult case of Fanconi syndrome due to a mixture of Chinese crude drugs.
Izumotani T, Ishimura E, Tsumura K, Goto K, Nishizawa Y, Morii H
Nephron 1993;65(1):137-40. doi: 10.1159/000187455. PMID: 8413772
Cadmium-induced osteomalacia.
Blainey JD, Adams RG, Brewer DB, Harvey TC
Br J Ind Med 1980 Aug;37(3):278-84. doi: 10.1136/oem.37.3.278. PMID: 7426480Free PMC Article

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