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First Trimester Antepartum Hemorrhage

MedGen UID:
909728
•Concept ID:
C4086315
•
Pathologic Function
Synonym: Antepartum Hemorrhage, First Trimester

Definition

Excessive blood loss within the first trimester but prior to onset of labor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFirst Trimester Antepartum Hemorrhage

Professional guidelines

PubMed

Management of parturients with Factor XI deficiency-10year case series and review of literature.
Verghese L, Tingi E, Thachil J, Hay C, Byrd L
Eur J Obstet Gynecol Reprod Biol 2017 Aug;215:85-92. Epub 2017 Jun 6 doi: 10.1016/j.ejogrb.2017.06.008. PMID: 28622635
Thrombosis during pregnancy: risk factors, diagnosis and treatment.
Pabinger I, Grafenhofer H
Pathophysiol Haemost Thromb 2002 Sep-Dec;32(5-6):322-4. doi: 10.1159/000073590. PMID: 13679666
Conservative management and pregnancy outcome in diethylstilbestrol-exposed women with and without gross genital tract abnormalities.
Levine RU, Berkowitz KM
Am J Obstet Gynecol 1993 Nov;169(5):1125-9. doi: 10.1016/0002-9378(93)90267-m. PMID: 8238171

Recent clinical studies

Etiology

Obstetric outcomes in women with pelvic endometriosis: a prospective cohort study.
Bean EMR, Knez J, Thanatsis N, De Braud L, Taki F, Hirsch M, David A, Jurkovic D
Fertil Steril 2024 Oct;122(4):696-705. Epub 2024 Jun 3 doi: 10.1016/j.fertnstert.2024.05.162. PMID: 38838806
First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia.
Cavoretto PI, Farina A, Salmeri N, Syngelaki A, Tan MY, Nicolaides KH
Am J Obstet Gynecol 2024 Oct;231(4):452.e1-452.e7. Epub 2024 Jan 18 doi: 10.1016/j.ajog.2024.01.008. PMID: 38244830
Antepartum and postpartum anemia: a narrative review.
Butwick AJ, McDonnell N
Int J Obstet Anesth 2021 Aug;47:102985. Epub 2021 Mar 29 doi: 10.1016/j.ijoa.2021.102985. PMID: 33893005
Placental abruption and hemorrhage-review of imaging appearance.
Fadl SA, Linnau KF, Dighe MK
Emerg Radiol 2019 Feb;26(1):87-97. Epub 2018 Aug 29 doi: 10.1007/s10140-018-1638-3. PMID: 30159815
Placental Sonolucencies in the First Trimester: Incidence and Clinical Significance.
Baldassarre RL, Gabe M, Pretorius DH, Ramos GA, Romine LE, Hull AD, Ballas J, Pettit KE
Ultrasound Q 2016 Mar;32(1):43-6. doi: 10.1097/RUQ.0000000000000171. PMID: 26280582

Diagnosis

Obstetric outcomes in women with pelvic endometriosis: a prospective cohort study.
Bean EMR, Knez J, Thanatsis N, De Braud L, Taki F, Hirsch M, David A, Jurkovic D
Fertil Steril 2024 Oct;122(4):696-705. Epub 2024 Jun 3 doi: 10.1016/j.fertnstert.2024.05.162. PMID: 38838806
The use of first and second-generation antipsychotic drugs and the potential to develop gestational diabetes mellitus among perinatal patients with psychosis.
Kulkarni J, Gurvich C, Gilbert H, Worsley R, Li Q, Karimi L
Schizophr Res 2023 Apr;254:22-26. Epub 2023 Feb 7 doi: 10.1016/j.schres.2023.01.030. PMID: 36758325
Antepartum and postpartum anemia: a narrative review.
Butwick AJ, McDonnell N
Int J Obstet Anesth 2021 Aug;47:102985. Epub 2021 Mar 29 doi: 10.1016/j.ijoa.2021.102985. PMID: 33893005
Placental abruption and hemorrhage-review of imaging appearance.
Fadl SA, Linnau KF, Dighe MK
Emerg Radiol 2019 Feb;26(1):87-97. Epub 2018 Aug 29 doi: 10.1007/s10140-018-1638-3. PMID: 30159815
Placental Sonolucencies in the First Trimester: Incidence and Clinical Significance.
Baldassarre RL, Gabe M, Pretorius DH, Ramos GA, Romine LE, Hull AD, Ballas J, Pettit KE
Ultrasound Q 2016 Mar;32(1):43-6. doi: 10.1097/RUQ.0000000000000171. PMID: 26280582

Therapy

Aspirin therapy is associated with a lower risk of pregnancy loss in both JAK2- and CALR-mutated essential thrombocythemia-A Mayo Clinic study of 200 pregnancies.
Gangat N, Singh A, Ilyas R, Loscocco GG, Elliott M, Begna K, Pardanani A, Tefferi A
Am J Hematol 2024 Oct;99(10):1862-1869. Epub 2024 Jun 12 doi: 10.1002/ajh.27416. PMID: 38867546
First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia.
Cavoretto PI, Farina A, Salmeri N, Syngelaki A, Tan MY, Nicolaides KH
Am J Obstet Gynecol 2024 Oct;231(4):452.e1-452.e7. Epub 2024 Jan 18 doi: 10.1016/j.ajog.2024.01.008. PMID: 38244830
The use of first and second-generation antipsychotic drugs and the potential to develop gestational diabetes mellitus among perinatal patients with psychosis.
Kulkarni J, Gurvich C, Gilbert H, Worsley R, Li Q, Karimi L
Schizophr Res 2023 Apr;254:22-26. Epub 2023 Feb 7 doi: 10.1016/j.schres.2023.01.030. PMID: 36758325
Thrombocytopenia in the first trimester predicts adverse pregnancy outcomes in obstetric antiphospholipid syndrome.
Jin J, Xu X, Hou L, Hou Y, Li J, Liang M, Li C
Front Immunol 2022;13:971005. Epub 2022 Aug 18 doi: 10.3389/fimmu.2022.971005. PMID: 36059524Free PMC Article
Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective.
Szpunar MJ
Public Health Nutr 2020 May;23(7):1173-1178. Epub 2019 Jan 18 doi: 10.1017/S136898001800366X. PMID: 30657106Free PMC Article

Prognosis

Aspirin therapy is associated with a lower risk of pregnancy loss in both JAK2- and CALR-mutated essential thrombocythemia-A Mayo Clinic study of 200 pregnancies.
Gangat N, Singh A, Ilyas R, Loscocco GG, Elliott M, Begna K, Pardanani A, Tefferi A
Am J Hematol 2024 Oct;99(10):1862-1869. Epub 2024 Jun 12 doi: 10.1002/ajh.27416. PMID: 38867546
First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia.
Cavoretto PI, Farina A, Salmeri N, Syngelaki A, Tan MY, Nicolaides KH
Am J Obstet Gynecol 2024 Oct;231(4):452.e1-452.e7. Epub 2024 Jan 18 doi: 10.1016/j.ajog.2024.01.008. PMID: 38244830
Thrombocytopenia in the first trimester predicts adverse pregnancy outcomes in obstetric antiphospholipid syndrome.
Jin J, Xu X, Hou L, Hou Y, Li J, Liang M, Li C
Front Immunol 2022;13:971005. Epub 2022 Aug 18 doi: 10.3389/fimmu.2022.971005. PMID: 36059524Free PMC Article
Placental Sonolucencies in the First Trimester: Incidence and Clinical Significance.
Baldassarre RL, Gabe M, Pretorius DH, Ramos GA, Romine LE, Hull AD, Ballas J, Pettit KE
Ultrasound Q 2016 Mar;32(1):43-6. doi: 10.1097/RUQ.0000000000000171. PMID: 26280582
Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review.
Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya S
BJOG 2010 Feb;117(3):245-57. Epub 2009 Nov 26 doi: 10.1111/j.1471-0528.2009.02427.x. PMID: 19943827

Clinical prediction guides

Obstetric outcomes in women with pelvic endometriosis: a prospective cohort study.
Bean EMR, Knez J, Thanatsis N, De Braud L, Taki F, Hirsch M, David A, Jurkovic D
Fertil Steril 2024 Oct;122(4):696-705. Epub 2024 Jun 3 doi: 10.1016/j.fertnstert.2024.05.162. PMID: 38838806
First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia.
Cavoretto PI, Farina A, Salmeri N, Syngelaki A, Tan MY, Nicolaides KH
Am J Obstet Gynecol 2024 Oct;231(4):452.e1-452.e7. Epub 2024 Jan 18 doi: 10.1016/j.ajog.2024.01.008. PMID: 38244830
The use of first and second-generation antipsychotic drugs and the potential to develop gestational diabetes mellitus among perinatal patients with psychosis.
Kulkarni J, Gurvich C, Gilbert H, Worsley R, Li Q, Karimi L
Schizophr Res 2023 Apr;254:22-26. Epub 2023 Feb 7 doi: 10.1016/j.schres.2023.01.030. PMID: 36758325
Prospective evaluation of placental abruption in nulliparous women.
Lueth A, Blue N, Silver RM, Allshouse A, Hoffman M, Grobman WA, Simhan HN, Reddy U, Haas DM
J Matern Fetal Neonatal Med 2022 Dec;35(25):8603-8610. Epub 2021 Nov 23 doi: 10.1080/14767058.2021.1989405. PMID: 34814777Free PMC Article
Placental Sonolucencies in the First Trimester: Incidence and Clinical Significance.
Baldassarre RL, Gabe M, Pretorius DH, Ramos GA, Romine LE, Hull AD, Ballas J, Pettit KE
Ultrasound Q 2016 Mar;32(1):43-6. doi: 10.1097/RUQ.0000000000000171. PMID: 26280582

Recent systematic reviews

Subsequent pregnancy outcomes after second trimester miscarriage or termination for medical/fetal reason: A systematic review and meta-analysis of observational studies.
Patel K, Pirie D, Heazell AEP, Morgan B, Woolner A
Acta Obstet Gynecol Scand 2024 Mar;103(3):413-422. Epub 2023 Nov 30 doi: 10.1111/aogs.14731. PMID: 38037500Free PMC Article
Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review.
Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya S
BJOG 2010 Feb;117(3):245-57. Epub 2009 Nov 26 doi: 10.1111/j.1471-0528.2009.02427.x. PMID: 19943827

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